PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32489337-8	2020	The garcinol-induced apoptosis was further confirmed by the detection of cleavage forms of PARP and caspase 3.	garcinol	4-12	poly(ADP-ribose) polymerase 1	Homo sapiens	91-95	
21462088-6	2011	The molecular mechanism of garcinol"s action on PaCa cells was investigated by targeting signaling moieties involved in apoptosis (X-IAP, cIAP, caspase-3, 9, and PARP cleavage), transcription factor NF-kappaB, believed to contribute toward a chemoresistance phenotype in pancreatic tumors, and molecules associated with neovascularization and metastasis (MMP-9, VEGF, IL-8, and PGE(2)).	garcinol	27-35	poly(ADP-ribose) polymerase 1	Homo sapiens	162-166	
11312881-5	2001	Treatment with garcinol caused induction of caspase-3/CPP32 activity in a dose- and time-dependent manner, but not caspase-1 activity, and induced the degradation of poly(ADP-ribose) polymerase (PARP).	garcinol	15-23	poly(ADP-ribose) polymerase 1	Homo sapiens	166-193	
11312881-5	2001	Treatment with garcinol caused induction of caspase-3/CPP32 activity in a dose- and time-dependent manner, but not caspase-1 activity, and induced the degradation of poly(ADP-ribose) polymerase (PARP).	garcinol	15-23	poly(ADP-ribose) polymerase 1	Homo sapiens	195-199	
11312881-12	2001	It is suggested that garcinol-induced apoptosis is triggered by the release of cytochrome c into the cytosol, procaspase-9 processing, activation of caspase-3 and caspase-2, degradation of PARP, and DNA fragmentation caused by the caspase-activated deoxyribonuclease through the digestion of DFF-45.	garcinol	21-29	poly(ADP-ribose) polymerase 1	Homo sapiens	189-193