PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26626087-7 2016 Results suggest that the reduced proportion of double TRH/MCT8 expressing cells may be limiting the entry of hypothalamic triiodothyronine to the greater number of TRH-expressing neurons from caudal PVN and be in part responsible for the high TRH expression in anorexia rats and for the lack of adaptation of their hypothalamic-pituitary-thyroid axis to their low food intake. Triiodothyronine 122-138 thyrotropin releasing hormone Rattus norvegicus 164-167 26626087-7 2016 Results suggest that the reduced proportion of double TRH/MCT8 expressing cells may be limiting the entry of hypothalamic triiodothyronine to the greater number of TRH-expressing neurons from caudal PVN and be in part responsible for the high TRH expression in anorexia rats and for the lack of adaptation of their hypothalamic-pituitary-thyroid axis to their low food intake. Triiodothyronine 122-138 thyrotropin releasing hormone Rattus norvegicus 54-57 26626087-7 2016 Results suggest that the reduced proportion of double TRH/MCT8 expressing cells may be limiting the entry of hypothalamic triiodothyronine to the greater number of TRH-expressing neurons from caudal PVN and be in part responsible for the high TRH expression in anorexia rats and for the lack of adaptation of their hypothalamic-pituitary-thyroid axis to their low food intake. Triiodothyronine 122-138 thyrotropin releasing hormone Rattus norvegicus 164-167 8606955-1 1995 Clinical trials of thyrotrophin-releasing hormone (TRH) in conjunction with antepartum glucocorticoid treatment in the prevention of respiratory distress syndrome is based on experimental evidence that fetal lung maturation is accelerated by exposure to raised concentrations of triiodothyronine (T3) in fetal plasma. Triiodothyronine 279-295 thyrotropin releasing hormone Rattus norvegicus 19-49 19602869-2 2010 TRH is expressed in other hypothalamic nuclei but is downregulated by 3,3",5-L-triiodothyronine (T(3)) exclusively in the PVN. Triiodothyronine 97-101 thyrotropin releasing hormone Rattus norvegicus 0-3 19602869-6 2010 RESULTS: In primary cultures of fetal hypothalamic cells, TRH mRNA levels rapidly diminished with 10 nM T(3) while they increased by 1 mM 8Br-cAMP (+/- T(3)). Triiodothyronine 104-108 thyrotropin releasing hormone Rattus norvegicus 58-61 11431141-4 2001 We have previously shown that triiodothyronine (T(3)) down-regulates pre-pro-TRH gene expression in vivo and in vitro. Triiodothyronine 30-46 thyrotropin releasing hormone Rattus norvegicus 73-80 11431141-4 2001 We have previously shown that triiodothyronine (T(3)) down-regulates pre-pro-TRH gene expression in vivo and in vitro. Triiodothyronine 48-53 thyrotropin releasing hormone Rattus norvegicus 73-80 11216637-4 2000 Studies with female rat adenohypophyseal cell cultures treated with 3,3",5"-triiodo-L-thyronine (T3) showed that hypothalamic/paracrine factors, including TRH, can also regulate PPII activity. Triiodothyronine 97-99 thyrotropin releasing hormone Rattus norvegicus 155-158 10465283-0 1999 Triiodothyronine down-regulates thyrotropin-releasing hormone (TRH) synthesis and decreases pTRH-(160-169) and insulin releases from fetal rat islets in culture. Triiodothyronine 0-16 thyrotropin releasing hormone Rattus norvegicus 32-61 10465283-0 1999 Triiodothyronine down-regulates thyrotropin-releasing hormone (TRH) synthesis and decreases pTRH-(160-169) and insulin releases from fetal rat islets in culture. Triiodothyronine 0-16 thyrotropin releasing hormone Rattus norvegicus 63-66 10465283-4 1999 We found that circulating T3 concentrations were inversely correlated with TRH levels in two physiopathological situations. Triiodothyronine 26-28 thyrotropin releasing hormone Rattus norvegicus 75-78 7621893-0 1995 Triiodo-L-thyronine enhances TRH-induced TSH release from perifused rat pituitaries and intracellular Ca2+ levels from dispersed pituitary cells. Triiodothyronine 0-19 thyrotropin releasing hormone Rattus norvegicus 29-32 12766327-10 2003 doses of TRH used produced changes in T(3) plasma levels, strongly suggesting that the effect on sympathetic activity is mediated by a central effect of TRH acting as a putative activator of ovarian sympathetic nerves. Triiodothyronine 38-42 thyrotropin releasing hormone Rattus norvegicus 9-12 12766327-10 2003 doses of TRH used produced changes in T(3) plasma levels, strongly suggesting that the effect on sympathetic activity is mediated by a central effect of TRH acting as a putative activator of ovarian sympathetic nerves. Triiodothyronine 38-42 thyrotropin releasing hormone Rattus norvegicus 153-156 9749801-4 1998 After treatment with triiodothyronine (T3) a dramatic increase in the mRNA levels of the TRH-DE and a decrease in the intensity of the TRH receptor could be observed in the anterior lobe of the pituitary. Triiodothyronine 21-37 thyrotropin releasing hormone Rattus norvegicus 89-92 9749801-4 1998 After treatment with triiodothyronine (T3) a dramatic increase in the mRNA levels of the TRH-DE and a decrease in the intensity of the TRH receptor could be observed in the anterior lobe of the pituitary. Triiodothyronine 39-41 thyrotropin releasing hormone Rattus norvegicus 89-92 9551251-0 1997 Interaction between triiodothyronine and ovarian steroid hormones on the regulation of the release of thyrotropin and thyrotropin-releasing hormone in vitro. Triiodothyronine 20-36 thyrotropin releasing hormone Rattus norvegicus 118-147 9551251-1 1997 In vivo and in vitro experiments were designed to examine [1] the effect of triiodothyronine (T3) and/or ovarian steroids on the spontaneous and thyrotropin-releasing hormone (TRH)-stimulated release of thyrotropin (TSH) by the anterior pituitary gland (AP) in vitro; and [2] the in vivo effects of T3 and ovarian steroids on TRH-release in vitro. Triiodothyronine 76-92 thyrotropin releasing hormone Rattus norvegicus 176-179 9551251-1 1997 In vivo and in vitro experiments were designed to examine [1] the effect of triiodothyronine (T3) and/or ovarian steroids on the spontaneous and thyrotropin-releasing hormone (TRH)-stimulated release of thyrotropin (TSH) by the anterior pituitary gland (AP) in vitro; and [2] the in vivo effects of T3 and ovarian steroids on TRH-release in vitro. Triiodothyronine 94-96 thyrotropin releasing hormone Rattus norvegicus 176-179 9551251-8 1997 Application of T3 in vitro prevented the release of TSH in response to TRH. Triiodothyronine 15-17 thyrotropin releasing hormone Rattus norvegicus 71-74 9225129-3 1997 Hormones and neurotransmitters, including thyroid hormone (T3), glucocorticoids, testosterone, and 5-HT initiate effects not only in the cardiovascular system, but also in the regulation of hypothalamic TRH. Triiodothyronine 59-61 thyrotropin releasing hormone Rattus norvegicus 203-206 8606955-1 1995 Clinical trials of thyrotrophin-releasing hormone (TRH) in conjunction with antepartum glucocorticoid treatment in the prevention of respiratory distress syndrome is based on experimental evidence that fetal lung maturation is accelerated by exposure to raised concentrations of triiodothyronine (T3) in fetal plasma. Triiodothyronine 279-295 thyrotropin releasing hormone Rattus norvegicus 51-54 8606955-1 1995 Clinical trials of thyrotrophin-releasing hormone (TRH) in conjunction with antepartum glucocorticoid treatment in the prevention of respiratory distress syndrome is based on experimental evidence that fetal lung maturation is accelerated by exposure to raised concentrations of triiodothyronine (T3) in fetal plasma. Triiodothyronine 297-299 thyrotropin releasing hormone Rattus norvegicus 19-49 8606955-1 1995 Clinical trials of thyrotrophin-releasing hormone (TRH) in conjunction with antepartum glucocorticoid treatment in the prevention of respiratory distress syndrome is based on experimental evidence that fetal lung maturation is accelerated by exposure to raised concentrations of triiodothyronine (T3) in fetal plasma. Triiodothyronine 297-299 thyrotropin releasing hormone Rattus norvegicus 51-54 7934981-1 1994 To investigate the uptake of triiodothyronine sulfate (T3S) and its effect on thyrotropin-releasing hormone (TRH)-induced thyrotropin (TSH) secretion, anterior pituitary cells were isolated from euthyroid rats and cultured for 3 days in medium containing 10% fetal calf serum. Triiodothyronine 55-58 thyrotropin releasing hormone Rattus norvegicus 109-112 1738433-4 1992 Furthermore, in vitro pre-treatment of anterior pituitaries with triiodothyronine (T3) produced a dose-dependent decrease in both TSH secretion and the formation of [3H]IP in response to TRH. Triiodothyronine 65-81 thyrotropin releasing hormone Rattus norvegicus 187-190 8299578-10 1994 The combination of 10(-9) M T3 and 10(-8) M Dex dramatically potentiated the effect of either treatment alone (T3, 8.9-fold rise; Dex, 37.2-fold rise) and increased TRH accumulation 251.2-fold (all P < 0.01). Triiodothyronine 28-30 thyrotropin releasing hormone Rattus norvegicus 165-168 1572297-0 1992 Thyrotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus is dependent upon feedback regulation by both triiodothyronine and thyroxine. Triiodothyronine 136-152 thyrotropin releasing hormone Rattus norvegicus 0-29 1572297-3 1992 The concentration of pro-TRH mRNA in the PVN of hypothyroid male rats receiving constant infusions of T3 over 7 days from ip implanted osmotic minipumps was studied by in situ hybridization histochemistry using computerized image analysis. Triiodothyronine 102-104 thyrotropin releasing hormone Rattus norvegicus 21-28 1957562-0 1991 Effects of triiodothyronine, triiodothyroacetic acid, iopanoic acid and iodide on the thyrotropin-releasing hormone-induced thyrotropin release from superfused rat pituitary fragments. Triiodothyronine 11-27 thyrotropin releasing hormone Rattus norvegicus 86-115 1738433-4 1992 Furthermore, in vitro pre-treatment of anterior pituitaries with triiodothyronine (T3) produced a dose-dependent decrease in both TSH secretion and the formation of [3H]IP in response to TRH. Triiodothyronine 83-85 thyrotropin releasing hormone Rattus norvegicus 187-190 2514397-0 1989 Exogenous triiodothyronine lowers thyrotropin-releasing hormone concentrations in the specific hypothalamic nucleus (paraventricular) involved in thyrotropin regulation and also in posterior nucleus. Triiodothyronine 10-26 thyrotropin releasing hormone Rattus norvegicus 34-63 1980023-10 1990 As expected however, plasma TSH and T3 levels were increased at 20 min and 2 h, respectively, following TRH infusions. Triiodothyronine 36-38 thyrotropin releasing hormone Rattus norvegicus 104-107 2563758-0 1989 Regulation of thyrotropin releasing hormone degrading enzymes in rat brain and pituitary by L-3,5,3"-triiodothyronine. Triiodothyronine 92-117 thyrotropin releasing hormone Rattus norvegicus 14-43 2502597-3 1989 TRH (1 nmol/l)-induced TSH release over 1 h was enhanced by 70% (P less than 0.01) following exposure to 10 nmol 1,25-(OH)2D3/l for 24 h. Pretreatment with T3 (1 pmol/l-1 mumol/l) for 24 h caused a dose-dependent inhibition of TRH-induced TSH release. Triiodothyronine 156-158 thyrotropin releasing hormone Rattus norvegicus 0-3 2502597-3 1989 TRH (1 nmol/l)-induced TSH release over 1 h was enhanced by 70% (P less than 0.01) following exposure to 10 nmol 1,25-(OH)2D3/l for 24 h. Pretreatment with T3 (1 pmol/l-1 mumol/l) for 24 h caused a dose-dependent inhibition of TRH-induced TSH release. Triiodothyronine 156-158 thyrotropin releasing hormone Rattus norvegicus 227-230 2502597-6 1989 The increment of TRH-induced TSH release resulting from 1,25-(OH)2D3 pretreatment was equivalent in the presence or absence of maximal inhibitory T3 concentrations. Triiodothyronine 146-148 thyrotropin releasing hormone Rattus norvegicus 17-20 3139393-0 1988 Triiodothyronine exerts direct cell-specific regulation of thyrotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus. Triiodothyronine 0-16 thyrotropin releasing hormone Rattus norvegicus 59-88 3090567-4 1986 TRH administration increased circulating T3 levels in sham-operated animals, but had no effects in either hypo- or hyperthyroid, thyroidectomized rats. Triiodothyronine 41-43 thyrotropin releasing hormone Rattus norvegicus 0-3 2840173-3 1988 Intraperitoneal injections of triiodothyronine for 8 weeks resulted in a selective 41% increase (P less than 0.02) in retinal TRH receptor levels without any changes in the pituitary and 4 other brain regions. Triiodothyronine 30-46 thyrotropin releasing hormone Rattus norvegicus 126-129 3118365-4 1987 Treatment with exogenous L-triiodothyronine (T3) reduced TRH mRNA to the same level in both hypothyroid and euthyroid animals. Triiodothyronine 25-43 thyrotropin releasing hormone Rattus norvegicus 57-60 3118365-4 1987 Treatment with exogenous L-triiodothyronine (T3) reduced TRH mRNA to the same level in both hypothyroid and euthyroid animals. Triiodothyronine 45-47 thyrotropin releasing hormone Rattus norvegicus 57-60 3927182-0 1985 Comparison of the ability of thyroxine and triiodothyronine to suppress TRH-induced TSH secretion by perfused rat anterior pituitary fragments. Triiodothyronine 43-59 thyrotropin releasing hormone Rattus norvegicus 72-75 6815406-0 1982 [Effects of thyroxine and triiodothyronine on the thyrotropin response to the thyrotropin releasing hormone in the rat]. Triiodothyronine 26-42 thyrotropin releasing hormone Rattus norvegicus 78-107 6819989-2 1982 These effects of TRH appeared both in the medium containing a higher concentration of serum and in that containing six growth factors, i.e. insulin, transferrin, parathyroid hormone, fibroblast growth factor, triiodothyronine, and multiplication-stimulating activity (MSA) instead of serum. Triiodothyronine 209-225 thyrotropin releasing hormone Rattus norvegicus 17-20 6785072-6 1981 Perifusion with 3.5 x 10(-5) M cycloheximide or 10(-6) M actinomycin D 1 h before and during T3 administration led to greater TSH release with TRH than in the presence of T3 alone. Triiodothyronine 93-95 thyrotropin releasing hormone Rattus norvegicus 143-146 6455047-0 1981 Thyrotropin releasing hormone (TRH): its changes in discrete hypothalamic areas after treatment with triiodothyronine, thyroidectomy and acute cold exposure. Triiodothyronine 101-117 thyrotropin releasing hormone Rattus norvegicus 0-29 6775931-0 1980 Effects of triiodothyronine on thyrotropin-releasing hormone-induced thyrotropin release in the neonatal rat. Triiodothyronine 11-27 thyrotropin releasing hormone Rattus norvegicus 31-60 6455047-0 1981 Thyrotropin releasing hormone (TRH): its changes in discrete hypothalamic areas after treatment with triiodothyronine, thyroidectomy and acute cold exposure. Triiodothyronine 101-117 thyrotropin releasing hormone Rattus norvegicus 31-34 80734-2 1978 Serum TSH and triiodothyronine (T3) responses to cold exposure (4 +/- 1 C) were abolished by administration of anti-TRH serum. Triiodothyronine 14-30 thyrotropin releasing hormone Rattus norvegicus 116-119 80734-2 1978 Serum TSH and triiodothyronine (T3) responses to cold exposure (4 +/- 1 C) were abolished by administration of anti-TRH serum. Triiodothyronine 32-34 thyrotropin releasing hormone Rattus norvegicus 116-119 33201916-1 2020 Thyroid hormone (T3) inhibits thyrotropin-releasing hormone (TRH) synthesis in the hypothalamic paraventricular nucleus (PVN). Triiodothyronine 17-19 thyrotropin releasing hormone Rattus norvegicus 30-59 33201916-1 2020 Thyroid hormone (T3) inhibits thyrotropin-releasing hormone (TRH) synthesis in the hypothalamic paraventricular nucleus (PVN). Triiodothyronine 17-19 thyrotropin releasing hormone Rattus norvegicus 61-64