PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21232100-5 2011 The relationship between GH secretion and thyroid function, as well as GH influence on the peripheral thyroxine (T4) to triiodothyronine (T3) deiodination, mediated by IGF-I, were identified. Triiodothyronine 120-136 growth hormone 1 Homo sapiens 71-73 21529443-4 2011 The effect of IGFBP-3 on the growth hormone promoter activity stimulated by triiodothyronine (T3) was determined by dual-luciferase reporter assay. Triiodothyronine 76-92 growth hormone 1 Homo sapiens 29-43 21529443-4 2011 The effect of IGFBP-3 on the growth hormone promoter activity stimulated by triiodothyronine (T3) was determined by dual-luciferase reporter assay. Triiodothyronine 94-96 growth hormone 1 Homo sapiens 29-43 21232100-5 2011 The relationship between GH secretion and thyroid function, as well as GH influence on the peripheral thyroxine (T4) to triiodothyronine (T3) deiodination, mediated by IGF-I, were identified. Triiodothyronine 138-140 growth hormone 1 Homo sapiens 71-73 15299990-7 2004 After growth hormone treatment serum concentration of Insulin like growth factor -1 (IGF-1) and triiodothyronine increased and concentration of serum free thyroxine decreased significantly in comparison to basal concentration. Triiodothyronine 96-112 growth hormone 1 Homo sapiens 6-20 18211968-0 2008 Growth hormone treatment of adults with Prader-Willi syndrome and growth hormone deficiency improves lean body mass, fractional body fat, and serum triiodothyronine without glucose impairment: results from the United States multicenter trial. Triiodothyronine 148-164 growth hormone 1 Homo sapiens 0-14 17242407-7 2007 Chromatin immunoprecipitation studies confirmed that unliganded TR.RXR recruits both complexes to the triiodothyronine-responsive region of growth hormone gene in vivo. Triiodothyronine 102-118 growth hormone 1 Homo sapiens 140-154 14759511-6 2004 The positive effect of GH on AdipoR2 expression could be reversed by withdrawal of the hormone for 24 h. In contrast, other key hormones involved in the regulation of insulin resistance and energy metabolism such as insulin, isoproterenol, dexamethasone, triiodothyronine, angiotensin 2, tumor necrosis factor alpha, and interleukin-6 did not influence AdipoR1 and AdipoR2 synthesis in vitro. Triiodothyronine 255-271 growth hormone 1 Homo sapiens 23-25 12475372-3 2002 In vivo administration of triiodothyronine (T(3)) or thyroxine (T(4)) significantly reduced pituitary and serum GH levels, as measured by homologous RIA. Triiodothyronine 26-42 growth hormone 1 Homo sapiens 112-114 12475372-9 2002 This demonstrated that the inhibition of T(3) on GH synthesis was mediated by a decrease in GH mRNA steady state levels. Triiodothyronine 41-45 growth hormone 1 Homo sapiens 49-51 12475372-9 2002 This demonstrated that the inhibition of T(3) on GH synthesis was mediated by a decrease in GH mRNA steady state levels. Triiodothyronine 41-45 growth hormone 1 Homo sapiens 92-94 12475372-5 2002 Both T(3) and T(4) inhibited GH release in a concentration-dependent manner, producing up to 50% inhibition at 10 nM, with an ED(50) of <0.2 nM, within the range of their physiological circulating levels. Triiodothyronine 5-9 growth hormone 1 Homo sapiens 29-31 11800514-6 2001 The pulsatile secretion of growth hormone, thyroid-stimulating hormone, prolactin and luteinizing hormone can be re-established by relevant combinations of releasing factors, which also substantially increase the circulating levels of insulin-like growth factor-1, growth hormone dependent binding proteins, thyroxine, tri-iodothyronine and testosterone. Triiodothyronine 319-336 growth hormone 1 Homo sapiens 27-41 12381331-4 2002 The impaired pulsatile secretion of growth hormone (GH), thyrotropin and gonadotropin can be re-amplified by relevant combinations of releasing factors, which also substantially increase circulating levels of insulin-like growth factor (IGF)-I, GH-dependent IGF-binding proteins, thyroxine, tri-iodothyronine, and testosterone. Triiodothyronine 291-308 growth hormone 1 Homo sapiens 36-50 12381331-4 2002 The impaired pulsatile secretion of growth hormone (GH), thyrotropin and gonadotropin can be re-amplified by relevant combinations of releasing factors, which also substantially increase circulating levels of insulin-like growth factor (IGF)-I, GH-dependent IGF-binding proteins, thyroxine, tri-iodothyronine, and testosterone. Triiodothyronine 291-308 growth hormone 1 Homo sapiens 52-54 11598378-4 2001 Using GH mRNA as an end point, we demonstrate that in hyperthyroid states GH mRNA levels are stimulated by triiodothyronine (T(3)) generated via D1, whereas in hypothyroidism, when D2 activity is markedly increased, GH mRNA is more responsive to tetraiodothyronine (T(4)) in a propylthiouracil-insensitive, reverse T(3)-suppressible manner. Triiodothyronine 107-123 growth hormone 1 Homo sapiens 74-76 11598378-4 2001 Using GH mRNA as an end point, we demonstrate that in hyperthyroid states GH mRNA levels are stimulated by triiodothyronine (T(3)) generated via D1, whereas in hypothyroidism, when D2 activity is markedly increased, GH mRNA is more responsive to tetraiodothyronine (T(4)) in a propylthiouracil-insensitive, reverse T(3)-suppressible manner. Triiodothyronine 107-123 growth hormone 1 Homo sapiens 74-76 11598378-4 2001 Using GH mRNA as an end point, we demonstrate that in hyperthyroid states GH mRNA levels are stimulated by triiodothyronine (T(3)) generated via D1, whereas in hypothyroidism, when D2 activity is markedly increased, GH mRNA is more responsive to tetraiodothyronine (T(4)) in a propylthiouracil-insensitive, reverse T(3)-suppressible manner. Triiodothyronine 125-129 growth hormone 1 Homo sapiens 74-76 11598378-4 2001 Using GH mRNA as an end point, we demonstrate that in hyperthyroid states GH mRNA levels are stimulated by triiodothyronine (T(3)) generated via D1, whereas in hypothyroidism, when D2 activity is markedly increased, GH mRNA is more responsive to tetraiodothyronine (T(4)) in a propylthiouracil-insensitive, reverse T(3)-suppressible manner. Triiodothyronine 125-129 growth hormone 1 Homo sapiens 74-76 10077348-12 1999 Growth hormone administration furthermore increases the peripheral conversion of thyroxine to triiodothyronine, which may contribute to the overall actions of GH on fuel and energy metabolism. Triiodothyronine 94-110 growth hormone 1 Homo sapiens 0-14 11105553-9 2000 CONCLUSIONS: Growth hormone replacement leads to a decrease in visceral fat, modulates the thyroid hormone levels by increasing peripheral conversion of thyroxine to triiodothyronine and probably is a physiological regulator of peripheral thyroxine metabolism, slightly deteriorates the carbohydrate metabolism, and results in an increase of bone mineral density of lumbar spine and femoral neck. Triiodothyronine 166-182 growth hormone 1 Homo sapiens 13-27 10927625-3 2000 Tri-iodothyronine (T3), thyroxine (T4) and 17beta-oestradiol (OE2) reduced GST activities, whereas testosterone, dihydrotestosterone, and human growth hormone (hGH) had little effect on total GST activity. Triiodothyronine 19-21 growth hormone 1 Homo sapiens 144-158 10077348-12 1999 Growth hormone administration furthermore increases the peripheral conversion of thyroxine to triiodothyronine, which may contribute to the overall actions of GH on fuel and energy metabolism. Triiodothyronine 94-110 growth hormone 1 Homo sapiens 159-161 8664976-2 1996 Growth hormone treatment of healthy and GH-deficient subjects is accompanied by increased conversion of thyroxine (T4) to triiodothyronine (T3) in peripheral tissues. Triiodothyronine 122-138 growth hormone 1 Homo sapiens 0-14 8769362-2 1996 Furthermore, the possible linkage between the well-known GH-induced increase in peripheral thyroxine (T4) to triiodothyronine (T3) generation and the effects of GH on lipid and lipoprotein metabolism has not been elucidated. Triiodothyronine 109-125 growth hormone 1 Homo sapiens 57-59 8769362-2 1996 Furthermore, the possible linkage between the well-known GH-induced increase in peripheral thyroxine (T4) to triiodothyronine (T3) generation and the effects of GH on lipid and lipoprotein metabolism has not been elucidated. Triiodothyronine 127-129 growth hormone 1 Homo sapiens 57-59 8664976-2 1996 Growth hormone treatment of healthy and GH-deficient subjects is accompanied by increased conversion of thyroxine (T4) to triiodothyronine (T3) in peripheral tissues. Triiodothyronine 140-142 growth hormone 1 Homo sapiens 0-14 8479953-7 1993 Long-term pretreatment of adipocytes with a combination of T3 and GH produced a similar increase in lipolysis with .3 ng GLU/mL as pretreatment with either T3 or GH alone. Triiodothyronine 156-158 growth hormone 1 Homo sapiens 66-68 7828350-0 1994 Growth hormone administration stimulates energy expenditure and extrathyroidal conversion of thyroxine to triiodothyronine in a dose-dependent manner and suppresses circadian thyrotrophin levels: studies in GH-deficient adults. Triiodothyronine 106-122 growth hormone 1 Homo sapiens 0-14 8778198-10 1996 Triiodothyronine did not change functional hepatic nitrogen clearance (36.7 +/- 3.2 l/h), but triiodothyronine given together with growth hormone abolished the effect of growth hormone functional hepatic nitrogen clearance (38.8 +/- 4.8 l/h). Triiodothyronine 94-110 growth hormone 1 Homo sapiens 170-184 8778198-12 1996 Triiodothyronine has no effect on functional hepatic nitrogen clearance, but given together with growth hormone, it abolishes the effect of growth hormone on functional hepatic nitrogen clearance. Triiodothyronine 0-16 growth hormone 1 Homo sapiens 140-154 8479953-7 1993 Long-term pretreatment of adipocytes with a combination of T3 and GH produced a similar increase in lipolysis with .3 ng GLU/mL as pretreatment with either T3 or GH alone. Triiodothyronine 59-61 growth hormone 1 Homo sapiens 162-164 33971491-1 2021 OBJECTIVE: Growth hormone (GH) replacement alters the peripheral interconversion of thyroxine (T4) and triiodothyronine (T3). Triiodothyronine 103-119 growth hormone 1 Homo sapiens 11-25 1634542-1 1992 The intact human growth hormone (hGH) gene is negatively regulated by triiodothyronine (T3) treatment in transfected rat pituitary tumor cells. Triiodothyronine 70-86 growth hormone 1 Homo sapiens 17-31 1634542-1 1992 The intact human growth hormone (hGH) gene is negatively regulated by triiodothyronine (T3) treatment in transfected rat pituitary tumor cells. Triiodothyronine 88-90 growth hormone 1 Homo sapiens 17-31 1778404-1 1991 The effect of a dietary triiodothyronine (T3) supplement, of either 0.1 or 0.5 microgram/g of feed, was studied on the thyrotropin-releasing hormone (TRH)-induced growth hormone (GH) secretion in sex-linked dwarf (dw) or normal (Dw) chicks of both sexes. Triiodothyronine 24-40 growth hormone 1 Homo sapiens 179-181 1778404-1 1991 The effect of a dietary triiodothyronine (T3) supplement, of either 0.1 or 0.5 microgram/g of feed, was studied on the thyrotropin-releasing hormone (TRH)-induced growth hormone (GH) secretion in sex-linked dwarf (dw) or normal (Dw) chicks of both sexes. Triiodothyronine 42-44 growth hormone 1 Homo sapiens 163-177 1778404-0 1991 Effect of triiodothyronine supplementation on thyrotropin-releasing hormone-induced growth hormone secretion in sex-linked dwarf and normal chicks. Triiodothyronine 10-26 growth hormone 1 Homo sapiens 84-98 2210033-0 1990 Triiodothyronine inhibits transcription from the human growth hormone promoter. Triiodothyronine 0-16 growth hormone 1 Homo sapiens 55-69 2128417-0 1990 Triiodothyronine administration reduces serum growth hormone levels and growth hormone responses to thyrotropin-releasing hormone in patients with anorexia nervosa. Triiodothyronine 0-16 growth hormone 1 Homo sapiens 46-60 2128417-0 1990 Triiodothyronine administration reduces serum growth hormone levels and growth hormone responses to thyrotropin-releasing hormone in patients with anorexia nervosa. Triiodothyronine 0-16 growth hormone 1 Homo sapiens 72-86 33971491-1 2021 OBJECTIVE: Growth hormone (GH) replacement alters the peripheral interconversion of thyroxine (T4) and triiodothyronine (T3). Triiodothyronine 121-123 growth hormone 1 Homo sapiens 27-29 33971491-7 2021 RESULTS: GH replacement provoked a decline in serum free T4 concentration (-1.09 +- 1.99 pmol/L; p = 0.02) and an increase in free T3 (+0.34 +- 0.15 pmol/L; p = 0.03); therefore, the free T3:free T4 ratio increased from 0.40 +- 0.02 to 0.47 +- 0.02 (p = 0.002). Triiodothyronine 131-133 growth hormone 1 Homo sapiens 9-11 33971491-7 2021 RESULTS: GH replacement provoked a decline in serum free T4 concentration (-1.09 +- 1.99 pmol/L; p = 0.02) and an increase in free T3 (+0.34 +- 0.15 pmol/L; p = 0.03); therefore, the free T3:free T4 ratio increased from 0.40 +- 0.02 to 0.47 +- 0.02 (p = 0.002). Triiodothyronine 188-190 growth hormone 1 Homo sapiens 9-11 33971491-1 2021 OBJECTIVE: Growth hormone (GH) replacement alters the peripheral interconversion of thyroxine (T4) and triiodothyronine (T3). Triiodothyronine 103-119 growth hormone 1 Homo sapiens 27-29 33971491-1 2021 OBJECTIVE: Growth hormone (GH) replacement alters the peripheral interconversion of thyroxine (T4) and triiodothyronine (T3). Triiodothyronine 121-123 growth hormone 1 Homo sapiens 11-25 2892854-1 1988 A reverse hemolytic plaque assay was used to measure the GH responses of fetal pituitary cells to GHRH, SRIH, T3 and glucocorticoids. Triiodothyronine 110-112 growth hormone 1 Homo sapiens 57-59 3130285-1 1988 While thyrotrophin-releasing hormone (TRH) stimulated growth hormone (GH) secretion in adult anesthetized cockerels, the GH response was blocked in anesthetized birds pretreated with thyroxine (T4) or triiodothyronine (T3). Triiodothyronine 201-217 growth hormone 1 Homo sapiens 121-123 3130285-1 1988 While thyrotrophin-releasing hormone (TRH) stimulated growth hormone (GH) secretion in adult anesthetized cockerels, the GH response was blocked in anesthetized birds pretreated with thyroxine (T4) or triiodothyronine (T3). Triiodothyronine 219-221 growth hormone 1 Homo sapiens 121-123 3584469-0 1987 L-triiodothyronine stimulates growth by means of an autocrine factor in a cultured growth-hormone-producing cell line. Triiodothyronine 0-18 growth hormone 1 Homo sapiens 83-97 3584469-1 1987 L-Triiodothyronine (T3) stimulates DNA synthesis and replication of cultured GC cells, a T3-responsive growth hormone (GH)-secreting cell line. Triiodothyronine 0-18 growth hormone 1 Homo sapiens 103-117 3584469-1 1987 L-Triiodothyronine (T3) stimulates DNA synthesis and replication of cultured GC cells, a T3-responsive growth hormone (GH)-secreting cell line. Triiodothyronine 20-22 growth hormone 1 Homo sapiens 103-117 6690887-6 1984 Serum thyroxine levels decreased and serum triiodothyronine (T3) levels increased in response to growth hormone therapy. Triiodothyronine 43-59 growth hormone 1 Homo sapiens 97-111 2428817-0 1986 The human growth hormone gene is negatively regulated by triiodothyronine when transfected into rat pituitary tumor cells. Triiodothyronine 57-73 growth hormone 1 Homo sapiens 10-24 6690887-6 1984 Serum thyroxine levels decreased and serum triiodothyronine (T3) levels increased in response to growth hormone therapy. Triiodothyronine 61-63 growth hormone 1 Homo sapiens 97-111 5317263-0 1971 Effects of thyroidectomy and triiodothyronine (T 3 ) on the synthesis and release of growth hormone (GH) and prolactin. Triiodothyronine 29-45 growth hormone 1 Homo sapiens 85-99 7208169-0 1981 Action of human growth hormone (hGH) on extrathyroidal conversion of thyroxine (T4) to triiodothyronine (T3) in children with hypopituitarism. Triiodothyronine 87-103 growth hormone 1 Homo sapiens 16-30 7208169-0 1981 Action of human growth hormone (hGH) on extrathyroidal conversion of thyroxine (T4) to triiodothyronine (T3) in children with hypopituitarism. Triiodothyronine 105-107 growth hormone 1 Homo sapiens 16-30 414908-0 1977 Effect of triiodothyronine on thyroliberin-induced somatotropin release in patients with acromegaly. Triiodothyronine 10-26 growth hormone 1 Homo sapiens 51-63 5317263-0 1971 Effects of thyroidectomy and triiodothyronine (T 3 ) on the synthesis and release of growth hormone (GH) and prolactin. Triiodothyronine 29-45 growth hormone 1 Homo sapiens 101-103 32229369-3 2020 In addition, growth hormone can enhance the metabolism of thyroxine to triiodothyronine, uncovering borderline TSH deficiency. Triiodothyronine 71-87 growth hormone 1 Homo sapiens 13-27 29658834-8 2018 RESULTS: Following GH replacement, free thyroxine concentration declined and free triiodothyronine level increased. Triiodothyronine 82-98 growth hormone 1 Homo sapiens 19-21 28951438-2 2017 In pituitary, the encoding genes for growth hormone (GH) and thyroid-stimulating hormone (TSH) are examples of genes regulated by triiodothyronine (T3) in a positive and negative way, respectively. Triiodothyronine 130-146 growth hormone 1 Homo sapiens 37-51 28951438-2 2017 In pituitary, the encoding genes for growth hormone (GH) and thyroid-stimulating hormone (TSH) are examples of genes regulated by triiodothyronine (T3) in a positive and negative way, respectively. Triiodothyronine 148-150 growth hormone 1 Homo sapiens 37-51