PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 4714554-0 1973 Effects of L-triiodothyronine on insulin secretion in man. Triiodothyronine 11-29 insulin Homo sapiens 33-40 33980776-0 2021 Free triiodothyronine /free thyroxine ratio as an index of deiodinase type 1 and 2 activities negatively correlates with casual serum insulin levels in patients with type 2 diabetes mellitus. Triiodothyronine 5-21 insulin Homo sapiens 134-141 4739852-0 1973 Effects of L-triiodothyronine on insulin secretion in man. Triiodothyronine 11-29 insulin Homo sapiens 33-40 33980776-1 2021 Free triiodothyronine/free thyroxine (FT3/FT4) ratio is considered as an index of the activities of iodothyronine deiodinase types 1 and 2 (DIO1 and DIO2, respectively) and is reportedly associated with insulin resistance in euthyroid adults. Triiodothyronine 5-21 insulin Homo sapiens 203-210 32774144-0 2020 High T3 Induces beta-Cell Insulin Resistance via Endoplasmic Reticulum Stress. Triiodothyronine 5-7 insulin Homo sapiens 26-33 33125689-0 2021 Free triiodothyronine/free thyroxine (FT3/FT4) ratio is strongly associated with insulin resistance in euthyroid and hypothyroid adults: a cross-sectional study. Triiodothyronine 5-21 insulin Homo sapiens 81-88 33125689-6 2021 The strongest noted correlations were those of insulin levels with free triiodothyronine/free thyroxine (FT3/FT4) ratio (r = 0.206, p < 0.001) and FT3 (r = 0.205, p < 0.001). Triiodothyronine 72-88 insulin Homo sapiens 47-54 32774144-5 2020 The results indicated that high levels of T3 significantly inhibited insulin secretion in beta-cell line. Triiodothyronine 42-44 insulin Homo sapiens 69-76 32774144-10 2020 These results suggest that high T3 levels can induce insulin resistance in beta-cell line by activating ERS and the apoptotic pathway. Triiodothyronine 32-34 insulin Homo sapiens 53-60 30013028-0 2018 Low total and free triiodothyronine levels are associated with insulin resistance in non-diabetic individuals. Triiodothyronine 19-35 insulin Homo sapiens 63-70 31571530-1 2019 Background: In numerous studies based predominantly on rodent models, administration of 3,5-diiodo-L-thyronine (3,5-T2), a metabolite of the thyroid hormones (TH) thyroxine (T4) and triiodo-L-thyronine (T3), was reported to cause beneficial health effects, including reversal of steatohepatosis and prevention of insulin resistance, in most instances without adverse thyrotoxic side effects. Triiodothyronine 182-201 insulin Homo sapiens 313-320 14759511-6 2004 The positive effect of GH on AdipoR2 expression could be reversed by withdrawal of the hormone for 24 h. In contrast, other key hormones involved in the regulation of insulin resistance and energy metabolism such as insulin, isoproterenol, dexamethasone, triiodothyronine, angiotensin 2, tumor necrosis factor alpha, and interleukin-6 did not influence AdipoR1 and AdipoR2 synthesis in vitro. Triiodothyronine 255-271 insulin Homo sapiens 167-174 28685559-4 2017 Insulin release and content (at 11.0 and 20 mmol/L glucose) were significantly (p less than 0.01) stimulated by 1-100 nmol/L T2 and 0.1 nmol/L-1.0 mumol/L T3, and inhibited with higher concentrations of both (110 mumol/L T2 and 10 mumol/L T3). Triiodothyronine 155-157 insulin Homo sapiens 0-7 28685559-4 2017 Insulin release and content (at 11.0 and 20 mmol/L glucose) were significantly (p less than 0.01) stimulated by 1-100 nmol/L T2 and 0.1 nmol/L-1.0 mumol/L T3, and inhibited with higher concentrations of both (110 mumol/L T2 and 10 mumol/L T3). Triiodothyronine 239-241 insulin Homo sapiens 0-7 25255697-5 2015 Free triiodothyronine correlated positively with all insulin secretion indices in the prediabetes group. Triiodothyronine 5-21 insulin Homo sapiens 53-60 25255697-8 2015 CONCLUSIONS: Free triiodothyronine is associated with both basal and glucose-stimulated insulin secretion in people with prediabetes who are euthyroid; therefore, the regulation of insulin secretion by thyroid hormones is a potentially novel therapeutic target for the treatment of diabetes. Triiodothyronine 18-34 insulin Homo sapiens 88-95 25255697-8 2015 CONCLUSIONS: Free triiodothyronine is associated with both basal and glucose-stimulated insulin secretion in people with prediabetes who are euthyroid; therefore, the regulation of insulin secretion by thyroid hormones is a potentially novel therapeutic target for the treatment of diabetes. Triiodothyronine 18-34 insulin Homo sapiens 181-188 20634638-0 2010 Free triiodothyronine is associated with smoking habit, independently of obesity, body fat distribution, insulin, and metabolic parameters. Triiodothyronine 5-21 insulin Homo sapiens 105-112 28487105-0 2017 Is free triiodothyronine important in the development of insulin resistance in healthy people? Triiodothyronine 8-24 insulin Homo sapiens 57-64 28487105-11 2017 In the univariate regression, we found association between free triiodothyronine tertiles and insulin resistance. Triiodothyronine 64-80 insulin Homo sapiens 94-101 28487105-12 2017 In the multivariate regression adjusted for age, sex, body mass index and thyroid stimulating hormone, the association between free triiodothyronine tertiles and insulin resistance remained; intermediate tertile (PR=1.54; CI95%: 1.10-2.15) and high tertile (PR=1.70; CI95%: 1.21-2.39). Triiodothyronine 132-148 insulin Homo sapiens 162-169 28487105-14 2017 CONCLUSIONS: High levels of free triiodothyronine are associated with insulin resistance. Triiodothyronine 33-49 insulin Homo sapiens 70-77 24936390-8 2014 RESULTS: Triiodothyronine was positively correlated with insulin but negatively correlated with glucose, high-density lipoprotein cholesterol (HDL-C), and CVR. Triiodothyronine 9-25 insulin Homo sapiens 57-64 22973308-6 2012 Recent literature reports upon complex hypothalamic and peripheral interactions between T2DM and thyroid, and suggests T(3) to enhance cholesterol synthesis and to have a role in insulin resistance states. Triiodothyronine 119-123 insulin Homo sapiens 179-186 21318144-9 2011 Pearson"s correlation revealed that insulin and HOMA-IR values positively correlated with triiodothyronine (T3) and free thyroxine (FT4) levels. Triiodothyronine 90-106 insulin Homo sapiens 36-43 21318144-9 2011 Pearson"s correlation revealed that insulin and HOMA-IR values positively correlated with triiodothyronine (T3) and free thyroxine (FT4) levels. Triiodothyronine 108-110 insulin Homo sapiens 36-43 18283245-3 2008 In this study, we investigated serum serum insulin levels and their correlations with thyroid-stimulating hormone (TSH), free thyroxine (FT4) and free triiodothyronine (FT3) in hypothyroid women. Triiodothyronine 151-167 insulin Homo sapiens 43-50 12445505-2 2002 The MH model characterizes the relationship between T(3) and insulin and the levels of triglycerides (TG), fasting insulin (FI), and fasting glucose (FG) and is introduced as a clinical method to assess insulin sensitivity and the status of metabolic homeostasis in lieu of current screening models advocated by the by American Diabetic Association (ADA). Triiodothyronine 52-56 insulin Homo sapiens 61-68 12445505-2 2002 The MH model characterizes the relationship between T(3) and insulin and the levels of triglycerides (TG), fasting insulin (FI), and fasting glucose (FG) and is introduced as a clinical method to assess insulin sensitivity and the status of metabolic homeostasis in lieu of current screening models advocated by the by American Diabetic Association (ADA). Triiodothyronine 52-56 insulin Homo sapiens 115-122 12445505-2 2002 The MH model characterizes the relationship between T(3) and insulin and the levels of triglycerides (TG), fasting insulin (FI), and fasting glucose (FG) and is introduced as a clinical method to assess insulin sensitivity and the status of metabolic homeostasis in lieu of current screening models advocated by the by American Diabetic Association (ADA). Triiodothyronine 52-56 insulin Homo sapiens 115-122 11521733-2 2001 Insulin and glucagon concentrations were significantly higher in pulmonary artery blood with respect to radial artery blood (73 +/- 65 vs. 65 +/- 47 pmol/l, p < 0.005, and 80 +/- 49 vs. 73 +/- 51 ng/l, p < 0.01, respectively), while no difference was found for growth hormone, prolactin, C peptide, insulin-like growth factor I, follicle stimulating hormone, luteinizing hormone, thyroid stimulating hormone, parathyroid hormone, thyroglobulin, triiodothyronine, thyroxine, free triiodothyronine, and free thyroxine. Triiodothyronine 451-467 insulin Homo sapiens 0-7 11521733-2 2001 Insulin and glucagon concentrations were significantly higher in pulmonary artery blood with respect to radial artery blood (73 +/- 65 vs. 65 +/- 47 pmol/l, p < 0.005, and 80 +/- 49 vs. 73 +/- 51 ng/l, p < 0.01, respectively), while no difference was found for growth hormone, prolactin, C peptide, insulin-like growth factor I, follicle stimulating hormone, luteinizing hormone, thyroid stimulating hormone, parathyroid hormone, thyroglobulin, triiodothyronine, thyroxine, free triiodothyronine, and free thyroxine. Triiodothyronine 485-501 insulin Homo sapiens 0-7 10784178-7 2000 In the presence of insulin, stimulation by T3 or hydrocortisone alone had no effect on glycerol 3-phosphate dehydrogenase activity, whereas their concomitant addition significantly increased it. Triiodothyronine 43-45 insulin Homo sapiens 19-26 10911773-8 2000 The higher plasma concentrations of triiodothyronine associated with lower concentrations of insulin could account for the leanness and the elevated diet-induced thermogenesis previously observed in the R+ line. Triiodothyronine 36-52 insulin Homo sapiens 93-100 8408055-1 1993 We have shown that culturing HepG2 cells in Ham"s F-12 medium supplemented with calf serum, dexamethasone, and triiodothyronine causes an increase in the insulin sensitivity and responsiveness for glucose incorporation into glycogen. Triiodothyronine 111-127 insulin Homo sapiens 154-161 10657854-11 2000 The effect of T(3) on glucose uptake induced by insulin can also be explained by the high expression of both glucose transporters. Triiodothyronine 14-18 insulin Homo sapiens 48-55 9856405-6 1998 beta-Hydroxybutyrate increased quadratically with phlorizin injection during 2 to 24 h and tended to increase quadratically during 8 to 72 h. The ratio of insulin to glucagon tended to decrease linearly with phlorizin injection during the 1st 24 h but was unaffected from 8 to 72 h. Triiodothyronine, but not thyroxine, tended to decrease linearly with phlorizin injection during 8 to 72 h. Cortisol was not affected by treatment. Triiodothyronine 283-299 insulin Homo sapiens 155-162 10658938-3 1999 We investigated the hypothesis that central obesity and insulin resistance are linked with an increased blood pressure and insulin production through elevated free serum triiodothyronine concentrations. Triiodothyronine 170-186 insulin Homo sapiens 56-63 10658938-3 1999 We investigated the hypothesis that central obesity and insulin resistance are linked with an increased blood pressure and insulin production through elevated free serum triiodothyronine concentrations. Triiodothyronine 170-186 insulin Homo sapiens 123-130 10658938-7 1999 RESULTS: Free serum triiodothyronine concentrations correlated, independent of age and gender, positively with systolic and diastolic blood pressure, insulin production and fasting insulin. Triiodothyronine 20-36 insulin Homo sapiens 150-157 10658938-7 1999 RESULTS: Free serum triiodothyronine concentrations correlated, independent of age and gender, positively with systolic and diastolic blood pressure, insulin production and fasting insulin. Triiodothyronine 20-36 insulin Homo sapiens 181-188 10658938-9 1999 The correlations of free serum triiodothyronine with blood pressure, insulin production and fasting insulin were independent of the waist:hip ratio and insulin sensitivity. Triiodothyronine 31-47 insulin Homo sapiens 69-76 10658938-9 1999 The correlations of free serum triiodothyronine with blood pressure, insulin production and fasting insulin were independent of the waist:hip ratio and insulin sensitivity. Triiodothyronine 31-47 insulin Homo sapiens 100-107 10658938-9 1999 The correlations of free serum triiodothyronine with blood pressure, insulin production and fasting insulin were independent of the waist:hip ratio and insulin sensitivity. Triiodothyronine 31-47 insulin Homo sapiens 100-107 9368511-8 1997 Conversely, 0-100 nmol/l insulin reduced SHBG production induced by 10 nmol/l T3. Triiodothyronine 78-80 insulin Homo sapiens 25-32 8598220-1 1996 In a previous study we have shown that triiodothyronine (T3) added to a serum-free medium supplemented with insulin, transferrin, and selenous acid (ITS) can stimulate Caco-2 cell differentiation. Triiodothyronine 39-55 insulin Homo sapiens 108-115 8598220-1 1996 In a previous study we have shown that triiodothyronine (T3) added to a serum-free medium supplemented with insulin, transferrin, and selenous acid (ITS) can stimulate Caco-2 cell differentiation. Triiodothyronine 57-59 insulin Homo sapiens 108-115 8568110-12 1995 Triiodothyronine (T3) was directly correlated in the cancer patients with non-oxidative glucose utilization at the two physiological insulin concentrations (r = 0.673, p < 0.05 and r = 0.731, p < 0.01) and the supraphysiological insulin concentration (r = 0.791, p < 0.01). Triiodothyronine 0-16 insulin Homo sapiens 133-140 8568110-12 1995 Triiodothyronine (T3) was directly correlated in the cancer patients with non-oxidative glucose utilization at the two physiological insulin concentrations (r = 0.673, p < 0.05 and r = 0.731, p < 0.01) and the supraphysiological insulin concentration (r = 0.791, p < 0.01). Triiodothyronine 0-16 insulin Homo sapiens 235-242 8568110-12 1995 Triiodothyronine (T3) was directly correlated in the cancer patients with non-oxidative glucose utilization at the two physiological insulin concentrations (r = 0.673, p < 0.05 and r = 0.731, p < 0.01) and the supraphysiological insulin concentration (r = 0.791, p < 0.01). Triiodothyronine 18-20 insulin Homo sapiens 133-140 8568110-12 1995 Triiodothyronine (T3) was directly correlated in the cancer patients with non-oxidative glucose utilization at the two physiological insulin concentrations (r = 0.673, p < 0.05 and r = 0.731, p < 0.01) and the supraphysiological insulin concentration (r = 0.791, p < 0.01). Triiodothyronine 18-20 insulin Homo sapiens 235-242 1730237-7 1992 Triiodothyronine overexpressed the Glc6P dehydrogenase mRNA induced by the presence of insulin at 6 d and 10 d of culture. Triiodothyronine 0-16 insulin Homo sapiens 87-94 2667643-5 1989 Triiodothyronine, alone or in the presence of insulin, increased lipogenesis and fatty acid synthase activity. Triiodothyronine 0-16 insulin Homo sapiens 46-53 1870419-0 1991 Triiodothyronine (T3)-associated upregulation and downregulation of nuclear T3 binding in the human fibroblast cell (MRC-5)--stimulation of malic enzyme, glucose-6-phosphate-dehydrogenase, and 6-phosphogluconate-dehydrogenase by insulin, but not by T3. Triiodothyronine 0-16 insulin Homo sapiens 229-236 1870419-0 1991 Triiodothyronine (T3)-associated upregulation and downregulation of nuclear T3 binding in the human fibroblast cell (MRC-5)--stimulation of malic enzyme, glucose-6-phosphate-dehydrogenase, and 6-phosphogluconate-dehydrogenase by insulin, but not by T3. Triiodothyronine 18-20 insulin Homo sapiens 229-236 1649730-4 1991 At rest, the fasting concentrations of insulin and pro-insulin correlated positively with the prevailing total tri-iodothyronine concentration, whereas the concentrations of noradrenaline and cortisol correlated inversely with the tri-iodothyronine concentration. Triiodothyronine 111-128 insulin Homo sapiens 39-46 1649730-4 1991 At rest, the fasting concentrations of insulin and pro-insulin correlated positively with the prevailing total tri-iodothyronine concentration, whereas the concentrations of noradrenaline and cortisol correlated inversely with the tri-iodothyronine concentration. Triiodothyronine 111-128 insulin Homo sapiens 55-62 34137729-3 2021 Metformin is used to decrease insulin resistance, and at present it is assumed to influence the effect of triiodothyronine, as well. Triiodothyronine 106-122 insulin Homo sapiens 30-37 35162474-11 2022 Insulin was claimed during 3.5% of pregnancies, most frequently in T3 (3.3%). Triiodothyronine 67-69 insulin Homo sapiens 0-7 3044137-4 1988 During hyperglycemia, 3,5,3"-triiodothyronine (T3) did not affect glucose disposal but increased carbohydrate-induced lipogenesis at both insulin infusion rates. Triiodothyronine 22-45 insulin Homo sapiens 138-145 3044137-4 1988 During hyperglycemia, 3,5,3"-triiodothyronine (T3) did not affect glucose disposal but increased carbohydrate-induced lipogenesis at both insulin infusion rates. Triiodothyronine 47-49 insulin Homo sapiens 138-145 3893986-0 1985 Insulin suppresses triiodothyronine-induced growth hormone secretion by GH3 rat pituitary cells. Triiodothyronine 19-35 insulin Homo sapiens 0-7 3153479-8 1987 Insulin alone or in combination with T3 or Dex was found to increase hGH mRNA levels in some cell lines and to decrease hGH mRNA levels in others; these effects were correlated strongly (r = 0.88; P less than 0.001) with the influence of insulin on the endogenous rat GH gene, implying that individual cellular differences can simultaneously affect the insulin responsiveness of both genes. Triiodothyronine 37-39 insulin Homo sapiens 238-245 3153479-8 1987 Insulin alone or in combination with T3 or Dex was found to increase hGH mRNA levels in some cell lines and to decrease hGH mRNA levels in others; these effects were correlated strongly (r = 0.88; P less than 0.001) with the influence of insulin on the endogenous rat GH gene, implying that individual cellular differences can simultaneously affect the insulin responsiveness of both genes. Triiodothyronine 37-39 insulin Homo sapiens 353-360 3799756-1 1987 Triiodothyronine has been found to enhance gonadotropin- and insulin-stimulated morphologic luteinization and progesterone production by porcine granulosa cells in culture. Triiodothyronine 0-16 insulin Homo sapiens 61-68 3904727-1 1985 Treatment of rat hepatoma cells with insulin, glucagon, thyroxine (T4) and triiodothyronine (T3) caused a concentration-dependent decrease in the monomeric actin content as measured by the deoxyribonuclease-I inhibition assay. Triiodothyronine 75-91 insulin Homo sapiens 37-44 3904727-1 1985 Treatment of rat hepatoma cells with insulin, glucagon, thyroxine (T4) and triiodothyronine (T3) caused a concentration-dependent decrease in the monomeric actin content as measured by the deoxyribonuclease-I inhibition assay. Triiodothyronine 93-95 insulin Homo sapiens 37-44 3893986-7 1985 This suppression was maximal with 3.5 nM insulin and occurred after a lag period of 48 h. The previously described 20-fold synergistic stimulation of GH by T3 (0.5 nM) together with HCT (1 microM) was also suppressed by insulin (3.5 nM) by 80% during 72 h of incubation. Triiodothyronine 156-158 insulin Homo sapiens 41-48 3893986-7 1985 This suppression was maximal with 3.5 nM insulin and occurred after a lag period of 48 h. The previously described 20-fold synergistic stimulation of GH by T3 (0.5 nM) together with HCT (1 microM) was also suppressed by insulin (3.5 nM) by 80% during 72 h of incubation. Triiodothyronine 156-158 insulin Homo sapiens 220-227 3893986-11 1985 Alternatively, the inhibitory effects of insulin on T3-induced GH secretion in these cells may be posttranscriptional. Triiodothyronine 52-54 insulin Homo sapiens 41-48 6392058-5 1984 Insulin (final concentration 0.7 I. U./ml) alone stimulated malic enzyme activity minimally, but together with triiodothyronine stimulation was additive. Triiodothyronine 111-127 insulin Homo sapiens 0-7 396977-0 1979 Effect of insulin-induced hypoglycemia on the serum concentrations of thyroxine, triiodothyronine and reverse triiodothyronine. Triiodothyronine 81-97 insulin Homo sapiens 10-17 396977-0 1979 Effect of insulin-induced hypoglycemia on the serum concentrations of thyroxine, triiodothyronine and reverse triiodothyronine. Triiodothyronine 110-126 insulin Homo sapiens 10-17 396977-3 1979 However, the T(3) concentrations rose from a mean basal level of 1.86 +/- 0.06 mug/l to a mean peak of 2.51 +/- 0.21 mug/l (P < 0.01) at 45 minutes after the insulin injection, and the rT(3) concentrations fell from a mean basal level of 0.184 +/- 0.008 mug/l to a mean nadir of 0.171 +/- 0.022 mug/l (not a significant change). Triiodothyronine 13-17 insulin Homo sapiens 161-168