PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24395638-2 2014 In this paper, we demonstrate that binding of TH T3 (triiodothyronine) to THRB induces senescence and deoxyribonucleic acid (DNA) damage in cultured cells and in tissues of young hyperthyroid mice. Triiodothyronine 46-51 thyroid hormone receptor beta Mus musculus 74-78 25672979-0 2015 Antitumor Responses Stimulated by Dendritic Cells Are Improved by Triiodothyronine Binding to the Thyroid Hormone Receptor beta. Triiodothyronine 66-82 thyroid hormone receptor beta Mus musculus 98-127 25016105-2 2014 TRbeta is a key protein mediating down-regulation of thyrotropin (TSH) expression by 3,3",5-tri-iodothyronine (T3), an active form of thyroid hormone. Triiodothyronine 85-109 thyroid hormone receptor beta Mus musculus 0-6 25016105-2 2014 TRbeta is a key protein mediating down-regulation of thyrotropin (TSH) expression by 3,3",5-tri-iodothyronine (T3), an active form of thyroid hormone. Triiodothyronine 111-113 thyroid hormone receptor beta Mus musculus 0-6 24440706-1 2014 Thyroid hormone (T3) stimulates various metabolic pathways and the hepatic actions of T3 are mediated primarily through the thyroid hormone receptor beta (TRbeta). Triiodothyronine 17-19 thyroid hormone receptor beta Mus musculus 124-153 24440706-1 2014 Thyroid hormone (T3) stimulates various metabolic pathways and the hepatic actions of T3 are mediated primarily through the thyroid hormone receptor beta (TRbeta). Triiodothyronine 17-19 thyroid hormone receptor beta Mus musculus 155-161 24395638-2 2014 In this paper, we demonstrate that binding of TH T3 (triiodothyronine) to THRB induces senescence and deoxyribonucleic acid (DNA) damage in cultured cells and in tissues of young hyperthyroid mice. Triiodothyronine 53-69 thyroid hormone receptor beta Mus musculus 74-78 24055033-2 2013 A negative feedback mechanism of thyroid-stimulating hormone (TSH, or thyrotropin) expression in the thyrotroph in the presence of triiodothyronine (T3) is employed by liganded thyroid hormone receptor beta (TRbeta) on the TSHbeta gene promoter, where conventional histone-modifying coactivators act as corepressors. Triiodothyronine 131-147 thyroid hormone receptor beta Mus musculus 177-206 24055033-2 2013 A negative feedback mechanism of thyroid-stimulating hormone (TSH, or thyrotropin) expression in the thyrotroph in the presence of triiodothyronine (T3) is employed by liganded thyroid hormone receptor beta (TRbeta) on the TSHbeta gene promoter, where conventional histone-modifying coactivators act as corepressors. Triiodothyronine 131-147 thyroid hormone receptor beta Mus musculus 208-214 24055033-2 2013 A negative feedback mechanism of thyroid-stimulating hormone (TSH, or thyrotropin) expression in the thyrotroph in the presence of triiodothyronine (T3) is employed by liganded thyroid hormone receptor beta (TRbeta) on the TSHbeta gene promoter, where conventional histone-modifying coactivators act as corepressors. Triiodothyronine 149-151 thyroid hormone receptor beta Mus musculus 177-206 24055033-2 2013 A negative feedback mechanism of thyroid-stimulating hormone (TSH, or thyrotropin) expression in the thyrotroph in the presence of triiodothyronine (T3) is employed by liganded thyroid hormone receptor beta (TRbeta) on the TSHbeta gene promoter, where conventional histone-modifying coactivators act as corepressors. Triiodothyronine 149-151 thyroid hormone receptor beta Mus musculus 208-214 19302190-5 2009 TRbeta(-/-) mice displayed higher basal levels of serum triiodothyronine (T(3)) and thyroxine (T(4)) compared to WT, reflecting thyroid hormone resistance. Triiodothyronine 56-72 thyroid hormone receptor beta Mus musculus 0-6 10595466-5 1999 The PV mutation is a C-insertion at codon 448 of the TRbeta gene and leads to a frame-shift of the carboxyl-terminal 14 amino acids of TRbeta1, resulting in total loss of triiodothyronine (T3) binding and transcriptional activation. Triiodothyronine 171-187 thyroid hormone receptor beta Mus musculus 53-59 10595466-5 1999 The PV mutation is a C-insertion at codon 448 of the TRbeta gene and leads to a frame-shift of the carboxyl-terminal 14 amino acids of TRbeta1, resulting in total loss of triiodothyronine (T3) binding and transcriptional activation. Triiodothyronine 189-191 thyroid hormone receptor beta Mus musculus 53-59 35038735-10 2022 Microarray analysis and GSEA showed that genes of the Wnt/beta-catenin pathway, among them Fzd8 (Frizzled receptor 8) and Ctnnb1 (beta-catenin), were positively enriched only in T3-treated WT and TRbeta 147F mice while anti-proliferative factor Btg2 was repressed. Triiodothyronine 178-180 thyroid hormone receptor beta Mus musculus 196-202 19137427-1 2010 3,5,3"-Triido-L: -thyronine (T3) exerts pleiotropic actions on development and homeostasis mostly via its nuclear receptors, TRalpha1, TRbeta1, and TRbeta2, encoded by the THRA and THRB genes. Triiodothyronine 29-31 thyroid hormone receptor beta Mus musculus 181-185 35038735-5 2022 METHODS: Wild type (WT) mice, TRbeta knockout mice (TRbeta KO), TRbeta mutant mice with either specifically abrogated DNA-binding (TRbeta GS) or abrogated direct PI3K activation (TRbeta 147F) were treated with T3 for 6h or 7 days. Triiodothyronine 210-212 thyroid hormone receptor beta Mus musculus 64-70 35038735-9 2022 RESULTS: T3 induced hepatocyte proliferation with an increased number of Ki67-positive cells in WT and TRbeta 147F mice (9.2+-6.5% and 10.1+-2.9%) compared to TRbeta KO and TRbeta GS mice (1.2+-1.1% and 1.5+-0.9%). Triiodothyronine 9-11 thyroid hormone receptor beta Mus musculus 103-109