PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32223187-0	2020	Triiodothyronine attenuates silica-induced oxidative stress, inflammation, and apoptosis via thyroid hormone receptor alpha in differentiated THP-1 macrophages.	Triiodothyronine	0-16	thyroid hormone receptor alpha	Homo sapiens	93-123	
34936295-12	2021	T3 affected apoptosis and cell cycle of glioma cells through regulating THRA and THRB expressions.	Triiodothyronine	0-2	thyroid hormone receptor alpha	Homo sapiens	72-76	
33176840-2	2020	RTH due to mutations of the THR-beta gene (hereafter, RTH-beta) is characterized by a decreased response of the target tissue to thyroid hormone, increased serum levels of free triiodothyronine (FT3) and/or free thyroxine (FT4), and inappropriate secretion of thyroid-stimulating hormone (TSH, normal or elevated).	Triiodothyronine	177-193	thyroid hormone receptor alpha	Homo sapiens	28-36	
34930399-2	2021	Thyroid hormone receptor alpha-2 (THRalpha-2) acts as an antagonist for triiodothyronine (T3) signaling, and a low expression has been associated with unfavorable tumor characteristics and a higher mortality in breast cancer.	Triiodothyronine	72-88	thyroid hormone receptor alpha	Homo sapiens	34-44	
34930399-2	2021	Thyroid hormone receptor alpha-2 (THRalpha-2) acts as an antagonist for triiodothyronine (T3) signaling, and a low expression has been associated with unfavorable tumor characteristics and a higher mortality in breast cancer.	Triiodothyronine	90-92	thyroid hormone receptor alpha	Homo sapiens	34-44	
34069457-4	2021	Most published disease-associated THRA variants are located in the LBD of THRA1 and impede triiodothyronine (T3) binding.	Triiodothyronine	91-107	thyroid hormone receptor alpha	Homo sapiens	34-38	
34069457-4	2021	Most published disease-associated THRA variants are located in the LBD of THRA1 and impede triiodothyronine (T3) binding.	Triiodothyronine	109-111	thyroid hormone receptor alpha	Homo sapiens	34-38	
30810960-8	2019	This study shows that triiodothyronine (T3) hormone makes some differences in heat capacity upon binding to the THR-beta ligand binding domain (LBD).	Triiodothyronine	22-38	thyroid hormone receptor alpha	Homo sapiens	112-120	
30747412-7	2019	In conclusion, THRA gene mutation should be considered in patients with clinical hypothyroid findings and increased/moderately elevated free T3, decreased/ normal free thyroxine, normal thyroid-stimulating hormone levels, and increased muscle enzymes.	Triiodothyronine	141-143	thyroid hormone receptor alpha	Homo sapiens	15-19	
30810960-8	2019	This study shows that triiodothyronine (T3) hormone makes some differences in heat capacity upon binding to the THR-beta ligand binding domain (LBD).	Triiodothyronine	40-42	thyroid hormone receptor alpha	Homo sapiens	112-120	
27094663-5	2016	Several other conditions that involve impaired sensitivity to thyroid hormone have been described in recent decades, and mutations have been identified in genes that code for thyroid hormone receptor alpha (TRalpha), a cell membrane transporter, as well as in the deiodinases that metabolise thyroxine (T4) to the bioactive form triiodothyronine (T3).	Triiodothyronine	329-345	thyroid hormone receptor alpha	Homo sapiens	175-205	
27809680-1	2017	BACKGROUND: Heterozygous mutations in the thyroid hormone receptor alpha (THRA) gene cause resistance to thyroid hormone alpha (RTHalpha), a disease characterized by variable manifestations reminiscent of untreated congenital hypothyroidism but a raised triiodothyronine/thyroxine ratio and normal thyrotropin levels.	Triiodothyronine	254-270	thyroid hormone receptor alpha	Homo sapiens	42-72	
27094663-5	2016	Several other conditions that involve impaired sensitivity to thyroid hormone have been described in recent decades, and mutations have been identified in genes that code for thyroid hormone receptor alpha (TRalpha), a cell membrane transporter, as well as in the deiodinases that metabolise thyroxine (T4) to the bioactive form triiodothyronine (T3).	Triiodothyronine	347-349	thyroid hormone receptor alpha	Homo sapiens	175-205	
14596673-0	2003	Triiodothyronine affects the alternative splicing of thyroid hormone receptor alpha mRNA.	Triiodothyronine	0-16	thyroid hormone receptor alpha	Homo sapiens	53-83	
24701358-9	2014	4-Hydroxytamoxifen, alone or associated with triiodothyronine, modulated gene expression of TNFRSF9, BMP-6, and THRA, similar to triiodothyronine treatment.	Triiodothyronine	45-61	thyroid hormone receptor alpha	Homo sapiens	112-116	
12538616-0	2003	Dronerarone acts as a selective inhibitor of 3,5,3"-triiodothyronine binding to thyroid hormone receptor-alpha1: in vitro and in vivo evidence.	Triiodothyronine	45-68	thyroid hormone receptor alpha	Homo sapiens	80-111	
12538616-6	2003	Debutyldronedarone inhibited T(3) binding to TRalpha(1) by 77%, but to TRbeta(1) by only 25%.	Triiodothyronine	29-33	thyroid hormone receptor alpha	Homo sapiens	45-55