PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34442729-3 2021 Here, we discovered that proline oxidation, catalyzed by the proline oxidase Put1, a mitochondrial flavin-dependent enzyme converting proline into 1-pyrroline-5-carboxylate, controls the chronological lifespan of the yeast Saccharomyces cerevisiae. delta-1-pyrroline-5-carboxylate 148-173 proline dehydrogenase Saccharomyces cerevisiae S288C 77-81