PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33389067-14 2021 Ponatinib (FGFR1 inhibitor) reversed the suppressive effects of miR-214 inhibition on lung injury and inflammation of VILI mice. ponatinib 0-9 fibroblast growth factor receptor 1 Mus musculus 11-16 22875613-4 2013 Ponatinib-treated Ba/F3 cells transformed by ZMYM2-FGFR1 and BCR-FGFR1 and the FGFR1OP2-FGFR1 positive KG1A cell line showed reduced proliferation and decreased survival when compared to control cells. ponatinib 0-9 fibroblast growth factor receptor 1 Mus musculus 51-56 32064608-4 2020 Cell/molecular biological and analytical chemistry methods were applied to investigate uptake kinetics/subcellular distribution, the role of lipid droplets (LDs) and lipoid microenvironment compartments in responsiveness of FGFR1-driven lung cancer cells towards ponatinib. ponatinib 263-272 fibroblast growth factor receptor 1 Mus musculus 224-229 28646488-3 2017 Since resistance to targeted therapies is a major reason for relapse, we developed FGFR1-overexpressing mouse and human cell lines that are resistant to the specific FGFR inhibitors AZD4547 and BGJ398, as well as non-specific inhibitors, such as ponatinib, TKI258 and E3810. ponatinib 246-255 fibroblast growth factor receptor 1 Mus musculus 83-88 28138694-0 2017 Activity of fibroblast growth factor receptor inhibitors TKI258, ponatinib and AZD4547 against TPR-FGFR1 fusion. ponatinib 65-74 fibroblast growth factor receptor 1 Mus musculus 99-104 28138694-4 2017 To identify the most promising drug for EMS, the activities and associated mechanism of three tyrosine kinase inhibitors (TKIs), TKI258, ponatinib and AZD4547, against TPR-FGFR1 were tested by MTT assay, flow cytometry and western blot. ponatinib 137-146 fibroblast growth factor receptor 1 Mus musculus 172-177 22875613-4 2013 Ponatinib-treated Ba/F3 cells transformed by ZMYM2-FGFR1 and BCR-FGFR1 and the FGFR1OP2-FGFR1 positive KG1A cell line showed reduced proliferation and decreased survival when compared to control cells. ponatinib 0-9 fibroblast growth factor receptor 1 Mus musculus 65-70 22238366-4 2012 In Ba/F3 cells engineered to express activated FGFR1-4, ponatinib potently inhibited FGFR-mediated signaling and viability with IC(50) values <40 nmol/L, with substantial selectivity over parental Ba/F3 cells. ponatinib 56-65 fibroblast growth factor receptor 1 Mus musculus 47-54