PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30572654-0	2018	Ponatinib Inhibits Multiple Signaling Pathways Involved in STAT3 Signaling and Attenuates Colorectal Tumor Growth.	ponatinib	0-9	signal transducer and activator of transcription 3	Homo sapiens	59-64	
30572654-2	2018	Here, we performed an extensive screen for STAT3 inhibitors among a library of 1167 FDA-approved agents, identifying Ponatinib as a lead candidate.	ponatinib	117-126	signal transducer and activator of transcription 3	Homo sapiens	43-48	
30572654-3	2018	We found that Ponatinib inhibits STAT3 activity driven by EGF/EGFR, IL-6/IL-6R and IL-11/IL-11R, three major ligand/receptor systems involved in CRC development and progression.	ponatinib	14-23	signal transducer and activator of transcription 3	Homo sapiens	33-38	
30572654-5	2018	In addition, Ponatinib displayed a greater ability to inhibit STAT3 activity and mediated superior anti-proliferative efficacy compared to five FDA approved SRC and Janus Kinase (JAK) inhibitors.	ponatinib	13-22	signal transducer and activator of transcription 3	Homo sapiens	62-67	
30572654-8	2018	Overall, our results identify a novel anti-STAT3 property of Ponatinib and thus, Ponatinib offers a potential therapeutic strategy for CRC.	ponatinib	61-70	signal transducer and activator of transcription 3	Homo sapiens	43-48	
30572654-8	2018	Overall, our results identify a novel anti-STAT3 property of Ponatinib and thus, Ponatinib offers a potential therapeutic strategy for CRC.	ponatinib	81-90	signal transducer and activator of transcription 3	Homo sapiens	43-48	
28619758-5	2017	Combination treatment with an MEK inhibitor and the multikinase inhibitor ponatinib was effective in targeting pancreatic cancer cells both in monolayer and spheroids by effectively blocking signaling via the PDGFRalpha and MEK kinases, while also preventing the activation of STAT3- and S6-mediated compensatory feedback loops in cancer cells.	ponatinib	74-83	signal transducer and activator of transcription 3	Homo sapiens	277-282	
24124571-9	2013	Phosphorylation of wild-type and mutated FGFR4 as well as its downstream target STAT3 was also suppressed by ponatinib.	ponatinib	109-118	signal transducer and activator of transcription 3	Homo sapiens	80-85	
28427224-7	2017	Ponatinib reduced merlin-deficient HSC viability in a dose-dependent manner by decreasing phosphorylation of PDGFRalpha/beta, AKT, p70S6K, MEK1/2, ERK1/2 and STAT3.	ponatinib	0-9	signal transducer and activator of transcription 3	Homo sapiens	158-163