PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31667872-0 2020 Promotion effects of mono-2-ethyhexyl phthalate (MEHP) on migration and invasion of human melanoma cells via activation of TGF-beta signals. mono-benzyl phthalate 21-47 transforming growth factor beta 1 Homo sapiens 123-131 31667872-0 2020 Promotion effects of mono-2-ethyhexyl phthalate (MEHP) on migration and invasion of human melanoma cells via activation of TGF-beta signals. mono-benzyl phthalate 49-53 transforming growth factor beta 1 Homo sapiens 123-131 31667872-4 2020 Among the tested cytokines, MEHP can increase the expression of transforming growth factor beta (TGF-beta). mono-benzyl phthalate 28-32 transforming growth factor beta 1 Homo sapiens 64-95 31667872-4 2020 Among the tested cytokines, MEHP can increase the expression of transforming growth factor beta (TGF-beta). mono-benzyl phthalate 28-32 transforming growth factor beta 1 Homo sapiens 97-105 31667872-5 2020 Inhibition of TGF-beta via its neutralization antibody can attenuate MEHP-induced cell migration and invasion. mono-benzyl phthalate 69-73 transforming growth factor beta 1 Homo sapiens 14-22 31667872-6 2020 Further, upregulation of TGF-beta mediated MEHP-induced activation of Smad signals and upregulation of Snail in melanoma cells. mono-benzyl phthalate 43-47 transforming growth factor beta 1 Homo sapiens 25-33 31667872-7 2020 Blocking the TGF-beta/Smad signal pathway can attenuate MEHP-induced cell migration. mono-benzyl phthalate 56-60 transforming growth factor beta 1 Homo sapiens 13-21 31667872-8 2020 Estrogen receptor alpha (ERalpha) was essential for MEHP-induced expression of TGF-beta. mono-benzyl phthalate 52-56 transforming growth factor beta 1 Homo sapiens 79-87 31667872-10 2020 Collectively, our study found that MEHP can stimulate the progression of melanoma via TGF-beta signals. mono-benzyl phthalate 35-39 transforming growth factor beta 1 Homo sapiens 86-94 31667872-12 2020 Our present study revealed that MEHP can trigger the in vitro migration and invasion of melanoma cells via upregulation of TGF-beta/Snail signals. mono-benzyl phthalate 32-36 transforming growth factor beta 1 Homo sapiens 123-131