PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26304078-0	2015	[In vitro study of BRD4 inhibitor GSK525762A against primary adult common B-cell acute lymphoblastic leukemia cells in vitro].	molibresib	34-44	bromodomain containing 4	Homo sapiens	19-23	
32793596-5	2020	Our screening analysis revealed that JQ1 and IBET-762, inhibitors of epigenetic reader BRD4, and LBH589, a pan inhibitor of histone deacetylases (HDACs), exhibited synergy with VS-6063 in mitigating tumor cell viability.	molibresib	45-53	bromodomain containing 4	Homo sapiens	87-91	
30539410-11	2019	We also found that, by displacing BRD4 from chromatin using the BET inhibitor iBET762, MEC cells lose their colony forming capacities and undergo G1 cell cycle arrest and senescence.	molibresib	78-85	bromodomain containing 4	Homo sapiens	34-38	
32631570-2	2020	By replacing the methyltriazole ring of the BRD4 inhibitor I-BET-762 with an N-methylthiazolidone heterocyclic ring, fifteen novel BRD4 inhibitors were designed and synthesized.	molibresib	59-68	bromodomain containing 4	Homo sapiens	44-48	
32631570-2	2020	By replacing the methyltriazole ring of the BRD4 inhibitor I-BET-762 with an N-methylthiazolidone heterocyclic ring, fifteen novel BRD4 inhibitors were designed and synthesized.	molibresib	59-68	bromodomain containing 4	Homo sapiens	131-135	
32392533-7	2020	Inhibition of BRD4 by siBRD4 or inhibitors such as JQ-1 or I-BET762 prevented the aging of macrophages and lipid accumulation in the LPS-induced senescent macrophages by decreasing expression of SASP in autocrine and paracrine senescence.	molibresib	59-67	bromodomain containing 4	Homo sapiens	14-18	
28281917-0	2017	BRD4 inhibitor IBET upregulates p27kip/cip protein stability in neuroendocrine tumor cells.	molibresib	15-19	bromodomain containing 4	Homo sapiens	0-4	
28281917-5	2017	In contrast, an inhibitor (IBET) to an epigenetic regulator, Brd4 that binds acetylated histones and upregulates transcription of multiple genes including protooncogene c-Myc, potently inhibited the NET cells.	molibresib	27-31	bromodomain containing 4	Homo sapiens	61-65	
28024472-0	2016	[Effect of BRD4 Inhibitor GSK525762A on Proliferation and Apoptosis of SUP-B15 Cells In Vitro and Its Possible Mechanism].	molibresib	26-36	bromodomain containing 4	Homo sapiens	11-15	
28024472-1	2016	OBJECTIVE: To investigate the effect of BRD4 inhibitor GSK525762A on the proliferation and apoptosis of Philadelphia chromosome-positive acute lymphoblastic leukemia SUP-B15 cells and its mechanism.	molibresib	55-65	bromodomain containing 4	Homo sapiens	40-44	
26304078-1	2015	OBJECTIVE: To investigate the effects of bromodomain-containing protein 4 (BRD4) inhibitor GSK525762A on the proliferation and apoptosis of primary common B-cell acute lymphoblastic leukemia (common B-ALL) cells from adult patients, then to further explore the possible mechanisms.	molibresib	91-101	bromodomain containing 4	Homo sapiens	41-73	
26304078-1	2015	OBJECTIVE: To investigate the effects of bromodomain-containing protein 4 (BRD4) inhibitor GSK525762A on the proliferation and apoptosis of primary common B-cell acute lymphoblastic leukemia (common B-ALL) cells from adult patients, then to further explore the possible mechanisms.	molibresib	91-101	bromodomain containing 4	Homo sapiens	75-79	
25338565-0	2014	[Effect of BRD4 inhibitor GSK525762A on proliferation and apoptosis of KU812 leukemic cells and its mechanism].	molibresib	26-36	bromodomain containing 4	Homo sapiens	11-15	
25338565-1	2014	This study was purposed to investigate the effect of bromodomain-containing protein 4 (BRD4) inhibitor GSK525762A on the proliferation and apoptosis of chronic myeloid leukemia blast crisis KU812 cells and its mechanism.	molibresib	103-113	bromodomain containing 4	Homo sapiens	53-85	
25338565-1	2014	This study was purposed to investigate the effect of bromodomain-containing protein 4 (BRD4) inhibitor GSK525762A on the proliferation and apoptosis of chronic myeloid leukemia blast crisis KU812 cells and its mechanism.	molibresib	103-113	bromodomain containing 4	Homo sapiens	87-91	
24985178-0	2014	[Effect of bromdomain protein 4 inhibitor GSK525762A on the proliferation and apoptosis of B-cell acute lymphoblastic leukemia cells and its mechanism].	molibresib	42-52	bromodomain containing 4	Homo sapiens	11-31	
24985178-1	2014	OBJECTIVE: To investigate the effect of bromdomain protein 4 (BRD4) inhibitor GSK525762A on the proliferation, apoptosis of B-cell acute lymphoblastic leukemia cell line RS4;11 cells, and to further explore the mechanism.	molibresib	78-88	bromodomain containing 4	Homo sapiens	40-60	
24985178-1	2014	OBJECTIVE: To investigate the effect of bromdomain protein 4 (BRD4) inhibitor GSK525762A on the proliferation, apoptosis of B-cell acute lymphoblastic leukemia cell line RS4;11 cells, and to further explore the mechanism.	molibresib	78-88	bromodomain containing 4	Homo sapiens	62-66	
24985178-2	2014	METHODS: Compared with Jurkat leukemia cells, the activity of BRD4 on RS4; 11 cells were inhibited by the inhibitor GSK525762A.	molibresib	116-126	bromodomain containing 4	Homo sapiens	62-66