PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32830148-7 2020 Delphinidin inhibited the phosphorylation of PI3K, AKT, and mTOR, and increased the expression of autophagy-induced cell death associated-protein in radiation-exposed NSCLC cells. delphinidin 0-11 AKT serine/threonine kinase 1 Homo sapiens 51-54 30537288-10 2019 Also, delphinidin prevented motility and invasiveness of EGF-induced HCC cells through suppressing activation of matrix metalloproteinase 2, EGF receptor (EGFR), AKT, and extracellular signal-regulated kinase (ERK). delphinidin 6-17 AKT serine/threonine kinase 1 Homo sapiens 162-165 30537288-11 2019 Taken together, our findings demonstrate that delphinidin inhibits EGF-induced EMT by inhibiting EGFR/AKT/ERK signaling pathway in HCC cells. delphinidin 46-57 AKT serine/threonine kinase 1 Homo sapiens 102-105 30320921-7 2019 Delphinidin decreased the phosphorylation of proliferative signaling molecules, including ERK1/2, AKT, P70S6K, and S6, while increasing the phosphorylation of P38 MAPK and P90RSK. delphinidin 0-11 AKT serine/threonine kinase 1 Homo sapiens 98-101 30365941-0 2019 Delphinidin protects beta2m-/Thy1+ bone marrow-derived hepatocyte stem cells against TGF-beta1-induced oxidative stress and apoptosis through the PI3K/Akt pathway in vitro. delphinidin 0-11 AKT serine/threonine kinase 1 Homo sapiens 151-154 30365941-12 2019 We also demonstrated that delphinidin can activate the phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway. delphinidin 26-37 AKT serine/threonine kinase 1 Homo sapiens 92-95 30365941-14 2019 In summary, our findings revealed that delphinidin can protect beta2m-/Thy1+ BDHSCs from apoptosis and ROS-dependent oxidative stress induced by the TGF-beta1 via PI3K/Akt signaling pathway. delphinidin 39-50 AKT serine/threonine kinase 1 Homo sapiens 168-171 29122484-9 2017 Also, delphinidin antagonized the phosphorylation of Akt and nuclear translocation of NF-kappaB permitted by the BDNF in SKOV3 ovarian cancer cells. delphinidin 6-17 AKT serine/threonine kinase 1 Homo sapiens 53-56 29122484-10 2017 Taken together, our findings provide new evidence that delphinidin suppressed the BDNF-induced ovarian cancer migration and invasion through decreasing of Akt activation. delphinidin 55-66 AKT serine/threonine kinase 1 Homo sapiens 155-158 28364098-0 2017 [Delphinidin induces autophagy in HER-2+ breast cancer cells via inhibition of AKT/mTOR pathway]. delphinidin 1-12 AKT serine/threonine kinase 1 Homo sapiens 79-82 28693237-0 2017 Inhibitory effects of delphinidin on the proliferation of ovarian cancer cells via PI3K/AKT and ERK 1/2 MAPK signal transduction. delphinidin 22-33 AKT serine/threonine kinase 1 Homo sapiens 88-91 28693237-8 2017 These results indicate that delphinidin inhibits the proliferation of SKOV3 cells through inactivation of PI3K/AKT and ERK1/2 mitogen-activated protein kinase signaling cascades, and that this cell signaling pathway may be a pivotal therapeutic target for the prevention of epithelial ovarian cancer, including paclitaxel-resistant ovarian cancer. delphinidin 28-39 AKT serine/threonine kinase 1 Homo sapiens 111-114 28364098-9 2017 Delphinidin inhibited the expression of proteins in mTOR signaling pathway, including AKT, mTOR, eIF4E and p70s6k. delphinidin 0-11 AKT serine/threonine kinase 1 Homo sapiens 86-89 28364098-10 2017 : Conclusion: Delphinidin induced apoptosis and autophagy by inhibition of AKT/mTOR pathway in HER positive breast cancer cells. delphinidin 15-26 AKT serine/threonine kinase 1 Homo sapiens 76-79 27959445-6 2017 We also found that delphinidin specifically decreased the CoCl2- and EGF-induced HIF-1alpha protein expression by blocking the ERK and PI3K/Akt/mTOR/p70S6K signaling pathways, whereas the p38-mediated pathways were not involved. delphinidin 19-30 AKT serine/threonine kinase 1 Homo sapiens 140-143 26704080-0 2016 Delphinidin suppresses proliferation and migration of human ovarian clear cell carcinoma cells through blocking AKT and ERK1/2 MAPK signaling pathways. delphinidin 0-11 AKT serine/threonine kinase 1 Homo sapiens 112-115 26704080-6 2016 Phosphorylation of downstream targets of PI3K (AKT and p70S6K) and MAPKs (ERK1/2 and JNK) signaling was suppressed by treatment of ES2 cells with delphinidin. delphinidin 146-157 AKT serine/threonine kinase 1 Homo sapiens 47-50 26704080-7 2016 In addition, pharmacological inhibitors of PI3K/AKT and ERK1/2 MAPK pathway improved the anti-proliferative action of delphinidin on ES2 cells. delphinidin 118-129 AKT serine/threonine kinase 1 Homo sapiens 48-51 26704080-10 2016 Collectively, these results indicated that delphinidin plays a critical role as a new chemotherapeutic agent to prevent development and progression of ES2 cells in CCC via inactivation of PI3K/AKT and ERK1/2 MAPK signal transduction cascades. delphinidin 43-54 AKT serine/threonine kinase 1 Homo sapiens 193-196 24792670-0 2014 Delphinidin inhibits VEGF induced-mitochondrial biogenesis and Akt activation in endothelial cells. delphinidin 0-11 AKT serine/threonine kinase 1 Homo sapiens 63-66 24792670-9 2014 These results suggest a possible association between inhibition of VEGF-induced mitochondrial biogenesis through Akt pathway by delphinidin and its anti-angiogenic effect, providing a novel mechanism sustaining the beneficial effect of delphinidin against pathologies associated with excessive angiogenesis such as cancers. delphinidin 128-139 AKT serine/threonine kinase 1 Homo sapiens 113-116 24792670-9 2014 These results suggest a possible association between inhibition of VEGF-induced mitochondrial biogenesis through Akt pathway by delphinidin and its anti-angiogenic effect, providing a novel mechanism sustaining the beneficial effect of delphinidin against pathologies associated with excessive angiogenesis such as cancers. delphinidin 236-247 AKT serine/threonine kinase 1 Homo sapiens 113-116 24124611-4 2013 Delphinidin (5-60 microM) treatment of NSCLC cells inhibited the activation of PI3K, and phosphorylation of AKT and MAPKs. delphinidin 0-11 AKT serine/threonine kinase 1 Homo sapiens 108-111 19174152-4 2009 Delphinidin inhibited the TNF-alpha-induced phosphorylations of JNK, p38 MAP kinase, Akt, p90RSK, MSK1, and ERK, and subsequently blocked the activation of the eukaryotic transcription factors AP-1 and NF-kappaB. delphinidin 0-11 AKT serine/threonine kinase 1 Homo sapiens 85-88 21103079-9 2010 We also found that hydrogen peroxide and delphinidin affected PI3K/Akt/mTOR signaling pathway which is one of upstream regulators of HIFs. delphinidin 41-52 AKT serine/threonine kinase 1 Homo sapiens 67-70 21103079-10 2010 In conclusion, hydrogen peroxide and antioxidant delphinidin seem to regulate intracellular level of p27 through regulating HIF-1 level which is, in turn, governed by its upstream regulators comprising of PI3K/Akt/mTOR signaling pathway. delphinidin 49-60 AKT serine/threonine kinase 1 Homo sapiens 210-213 18623129-5 2008 Delphinidin (5-40 microM; 3 hr) treatment of both AU-565 cells and MCF-10A cells inhibited the (i) phosphorylation of EGFR, (ii) activation of PI3K, (iii) phosphorylation of AKT and MAPK. delphinidin 0-11 AKT serine/threonine kinase 1 Homo sapiens 174-177 18623129-6 2008 Further, delphinidin treatment of AU-565 cells inhibited EGF-induced autophosphorylation of EGFR, AKT and MAPK, activation of PI3K and cell invasion. delphinidin 9-20 AKT serine/threonine kinase 1 Homo sapiens 98-101 18499206-5 2008 In addition, delphinidin treatment resulted in significant inhibition of HGF-activated (i) Ras-ERK MAPKs and (ii) PI3K/AKT/mTOR/p70S6K pathways. delphinidin 13-24 AKT serine/threonine kinase 1 Homo sapiens 119-122