PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19776176-3	2009	Here, we investigated the effects of delphinidin, an abundant dietary anthocyanin, on UVB-induced COX-2 upregulation and the underlying molecular mechanism.	delphinidin	37-48	prostaglandin-endoperoxide synthase 2	Mus musculus	98-103	
19776176-4	2009	We found that delphinidin suppressed UVB-induced COX-2 expression in JB6 P+ mouse epidermal cells.	delphinidin	14-25	prostaglandin-endoperoxide synthase 2	Mus musculus	49-54	
19776176-5	2009	COX-2 promoter activity and PGE(2) production were also suppressed by delphinidin treatment within non-cytotoxic concentrations.	delphinidin	70-81	prostaglandin-endoperoxide synthase 2	Mus musculus	0-5	
19776176-6	2009	Activator protein-1 and nuclear factor-kappaB, crucial transcription factors involved in COX-2 expression, were activated by UVB and delphinidin abolished this activation.	delphinidin	133-144	prostaglandin-endoperoxide synthase 2	Mus musculus	89-94	
19776176-10	2009	Moreover, in vivo investigations using mouse skin revealed that the upregulation of COX-2 expression, MAPKK4 activity and PI-3K activity induced by UVB was abolished with delphinidin treatment.	delphinidin	171-182	prostaglandin-endoperoxide synthase 2	Mus musculus	84-89	
19776176-11	2009	Collectively, our results demonstrated that delphinidin targets MAPKK4 and PI-3K directly to suppress COX-2 overexpression, suggesting a potential protective role for delphinidin against UVB-mediated skin carcinogenesis.	delphinidin	44-55	prostaglandin-endoperoxide synthase 2	Mus musculus	102-107	
19139002-4	2008	Here, we report that delphinidin, a major dietary anthocyanidin, inhibits tumor promoter-induced transformation and cyclooxygenase-2 (COX-2) expression in JB6 promotion-sensitive mouse skin epidermal (JB6 P+) cells by directly targeting Raf and mitogen-activated protein kinase kinase (MEK).	delphinidin	21-32	prostaglandin-endoperoxide synthase 2	Mus musculus	116-132	
19139002-11	2008	Together, these findings suggested that the targeted inhibition of Raf1 and MEK activities and COX-2 expression by delphinidin contribute to the chemopreventive potential of fruits and vegetables.	delphinidin	115-126	prostaglandin-endoperoxide synthase 2	Mus musculus	95-100	
19139002-4	2008	Here, we report that delphinidin, a major dietary anthocyanidin, inhibits tumor promoter-induced transformation and cyclooxygenase-2 (COX-2) expression in JB6 promotion-sensitive mouse skin epidermal (JB6 P+) cells by directly targeting Raf and mitogen-activated protein kinase kinase (MEK).	delphinidin	21-32	prostaglandin-endoperoxide synthase 2	Mus musculus	134-139	
19139002-5	2008	Delphinidin inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced neoplastic transformation and COX-2 expression at both the protein and transcriptional levels.	delphinidin	0-11	prostaglandin-endoperoxide synthase 2	Mus musculus	103-108	
15963474-2	2005	Of five anthocyanidins, delphinidin and cyanidin inhibited LPS-induced COX-2 expression, but pelargonidin, peonidin and malvidin did not.	delphinidin	24-35	prostaglandin-endoperoxide synthase 2	Mus musculus	71-76	
15963474-8	2005	Thus, our results demonstrated that LPS-induced COX-2 expression by activating MAPK pathways and delphinidin suppressed COX-2 by blocking MAPK-mediated pathways with the attendant activation of nuclear factor-kappaB (NF-kappaB), activator protein-1 (AP-1) and C/EBPdelta.	delphinidin	97-108	prostaglandin-endoperoxide synthase 2	Mus musculus	120-125	
15963474-4	2005	Delphinidin, the most potent inhibitor, caused a dose-dependent inhibition of COX-2 expression at both mRNA and protein levels.	delphinidin	0-11	prostaglandin-endoperoxide synthase 2	Mus musculus	78-83