PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19174152-4	2009	Delphinidin inhibited the TNF-alpha-induced phosphorylations of JNK, p38 MAP kinase, Akt, p90RSK, MSK1, and ERK, and subsequently blocked the activation of the eukaryotic transcription factors AP-1 and NF-kappaB.	delphinidin	0-11	mitogen-activated protein kinase 1	Homo sapiens	108-111	
16921400-0	2006	Delphinidin and cyanidin inhibit PDGF(AB)-induced VEGF release in vascular smooth muscle cells by preventing activation of p38 MAPK and JNK.	delphinidin	0-11	mitogen-activated protein kinase 1	Homo sapiens	123-126	
19139002-10	2008	Delphinidin also dose dependently suppressed JB6 P+ cell transformation induced by epidermal growth factor and H-Ras, both of which are involved in the activation of Raf/MEK/ERK signaling.	delphinidin	0-11	mitogen-activated protein kinase 1	Homo sapiens	174-177	
14514663-5	2004	Delphinidin, but not peonidin, blocked the phosphorylation of protein kinases in the extracellular signal-regulated protein kinase (ERK) pathway at early times and the c-Jun N-terminal kinase (JNK) signaling pathway at later times.	delphinidin	0-11	mitogen-activated protein kinase 1	Homo sapiens	85-130	
14514663-5	2004	Delphinidin, but not peonidin, blocked the phosphorylation of protein kinases in the extracellular signal-regulated protein kinase (ERK) pathway at early times and the c-Jun N-terminal kinase (JNK) signaling pathway at later times.	delphinidin	0-11	mitogen-activated protein kinase 1	Homo sapiens	132-135	
34712357-0	2021	Delphinidin induces cell cycle arrest and apoptosis in HER-2 positive breast cancer cell lines by regulating the NF-kappaB and MAPK signaling pathways.	delphinidin	0-11	mitogen-activated protein kinase 1	Homo sapiens	127-131	
34712357-4	2021	In addition, delphinidin promoted the mitochondrial apoptosis pathway by inhibiting the ERK and NF-kappaB signaling pathway and activating the JNK signaling pathway.	delphinidin	13-24	mitogen-activated protein kinase 1	Homo sapiens	88-91	
30537288-10	2019	Also, delphinidin prevented motility and invasiveness of EGF-induced HCC cells through suppressing activation of matrix metalloproteinase 2, EGF receptor (EGFR), AKT, and extracellular signal-regulated kinase (ERK).	delphinidin	6-17	mitogen-activated protein kinase 1	Homo sapiens	171-208	
30537288-10	2019	Also, delphinidin prevented motility and invasiveness of EGF-induced HCC cells through suppressing activation of matrix metalloproteinase 2, EGF receptor (EGFR), AKT, and extracellular signal-regulated kinase (ERK).	delphinidin	6-17	mitogen-activated protein kinase 1	Homo sapiens	210-213	
30537288-11	2019	Taken together, our findings demonstrate that delphinidin inhibits EGF-induced EMT by inhibiting EGFR/AKT/ERK signaling pathway in HCC cells.	delphinidin	46-57	mitogen-activated protein kinase 1	Homo sapiens	106-109	
29451351-0	2018	Delphinidin induces apoptosis and inhibits epithelial-to-mesenchymal transition via the ERK/p38 MAPK-signaling pathway in human osteosarcoma cell lines.	delphinidin	0-11	mitogen-activated protein kinase 1	Homo sapiens	88-91	
29451351-10	2018	Furthermore, delphinidin treatment resulted in a profound reduction of phosphorylated forms of ERK and p38.	delphinidin	13-24	mitogen-activated protein kinase 1	Homo sapiens	95-98	
29451351-11	2018	These findings demonstrate that delphinidin treatment suppressed EMT through the mitogen-activated protein kinase (MAPK) signaling pathway in OS cell lines.	delphinidin	32-43	mitogen-activated protein kinase 1	Homo sapiens	115-119	
29451351-13	2018	Delphinidin treatment also suppresses cell migration and prevents EMT via the MAPK-signaling pathway in OS cell lines.	delphinidin	0-11	mitogen-activated protein kinase 1	Homo sapiens	78-82	
28693237-5	2017	The levels of phosphorylated protein kinase B (AKT), ribosomal protein S6 kinase beta-1 (P70S6K), ribosomal protein S (S6), extracellular signal-regulated kinase (ERK)1/2 and p38 were suppressed by increasing concentrations of delphinidin.	delphinidin	227-238	mitogen-activated protein kinase 1	Homo sapiens	124-170	
25177436-0	2014	Delphinidin Inhibits LPS-Induced MUC8 and MUC5B Expression Through Toll-like Receptor 4-Mediated ERK1/2 and p38 MAPK in Human Airway Epithelial Cells.	delphinidin	0-11	mitogen-activated protein kinase 1	Homo sapiens	108-111	
33955636-8	2021	Inhibition of STAT-3, p38, and ERK1/2 phosphorylation and modulation pro-apoptotic protein expression might be responsible for the anticancer activity of delphinidin in colon cancer cells.	delphinidin	154-165	mitogen-activated protein kinase 1	Homo sapiens	22-25	
25177436-11	2014	Delphinidin (50 and 100 microM) inhibited LPS-induced TLR4, MUC8, and MUC5B expression and LPS-induced phosphorylation of ERK1/2 and p38 MAPK.	delphinidin	0-11	mitogen-activated protein kinase 1	Homo sapiens	133-136	
25177436-13	2014	CONCLUSION: These results suggest that delphinidin attenuates LPS-induced MUC8 and MUC5B expression through the TLR4-mediated ERK1/2 and p38 MAPK signaling pathway in human airway epithelial cells.	delphinidin	39-50	mitogen-activated protein kinase 1	Homo sapiens	137-140