PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12136238-4 2002 We previously described a DHS at +15.6 kb 3" to the CFTR gene, which showed tissue specificity in vivo and was evaluated as a candidate regulatory element for CFTR. dhs 26-29 CF transmembrane conductance regulator Homo sapiens 52-56 12136238-4 2002 We previously described a DHS at +15.6 kb 3" to the CFTR gene, which showed tissue specificity in vivo and was evaluated as a candidate regulatory element for CFTR. dhs 26-29 CF transmembrane conductance regulator Homo sapiens 159-163 10708521-3 2000 We previously characterized DHS at -79.5 and -20.9 kb with respect to the CFTR translational start site, DHS 3" to the gene at 4574 + 5.4-7.4 and 4574 + 15.6 kb, and a regulatory element in the first intron of the gene at 185 + 10 kb. dhs 28-31 CF transmembrane conductance regulator Homo sapiens 74-78 10708521-4 2000 We generated a cosmid contig to provide probes to evaluate the whole of the CFTR gene for DHS and have now mapped novel sites in introns 2, 3, 10, 16, 17a, 18, 20, and 21. dhs 90-93 CF transmembrane conductance regulator Homo sapiens 76-80 23689137-1 2013 An airway-selective DNase-hypersensitive site (DHS) at kb -35 (DHS-35kb) 5" to the cystic fibrosis transmembrane conductance regulator (CFTR) gene is evident in many lung cell lines and primary human tracheal epithelial cells but is absent from intestinal epithelia. dhs 47-50 CF transmembrane conductance regulator Homo sapiens 83-134 23689137-1 2013 An airway-selective DNase-hypersensitive site (DHS) at kb -35 (DHS-35kb) 5" to the cystic fibrosis transmembrane conductance regulator (CFTR) gene is evident in many lung cell lines and primary human tracheal epithelial cells but is absent from intestinal epithelia. dhs 47-50 CF transmembrane conductance regulator Homo sapiens 136-140 23689137-1 2013 An airway-selective DNase-hypersensitive site (DHS) at kb -35 (DHS-35kb) 5" to the cystic fibrosis transmembrane conductance regulator (CFTR) gene is evident in many lung cell lines and primary human tracheal epithelial cells but is absent from intestinal epithelia. dhs 63-66 CF transmembrane conductance regulator Homo sapiens 83-134 23689137-1 2013 An airway-selective DNase-hypersensitive site (DHS) at kb -35 (DHS-35kb) 5" to the cystic fibrosis transmembrane conductance regulator (CFTR) gene is evident in many lung cell lines and primary human tracheal epithelial cells but is absent from intestinal epithelia. dhs 63-66 CF transmembrane conductance regulator Homo sapiens 136-140 23689137-8 2013 Our results reveal that the DHS-35kb airway-selective enhancer element plays a pivotal role in regulation of CFTR expression by two independent regulatory mechanisms. dhs 28-31 CF transmembrane conductance regulator Homo sapiens 109-113 17696881-7 2007 Histone-modification analysis across the CFTR locus highlights structural differences between the -20.9 kb and +15.6 kb DHS, further suggesting that these two insulator elements may operate by distinct mechanisms. dhs 120-123 CF transmembrane conductance regulator Homo sapiens 41-45 11856314-3 2002 We previously identified at least 12 clusters of DHS across the CFTR gene and here further evaluate DHS in introns 2, 3, 10, 16, 17a, 18, 20 and 21 to assess their functional importance in regulation of CFTR gene expression. dhs 49-52 CF transmembrane conductance regulator Homo sapiens 64-68 11856314-3 2002 We previously identified at least 12 clusters of DHS across the CFTR gene and here further evaluate DHS in introns 2, 3, 10, 16, 17a, 18, 20 and 21 to assess their functional importance in regulation of CFTR gene expression. dhs 100-103 CF transmembrane conductance regulator Homo sapiens 203-207 11856314-6 2002 Cell specificity of the DHS suggested a role for the DHS in introns 2 and 18 in CFTR expression in some pancreatic duct cells. dhs 24-27 CF transmembrane conductance regulator Homo sapiens 80-84 11856314-6 2002 Cell specificity of the DHS suggested a role for the DHS in introns 2 and 18 in CFTR expression in some pancreatic duct cells. dhs 53-56 CF transmembrane conductance regulator Homo sapiens 80-84 11856314-7 2002 Finally, regulatory elements at the DHS in introns 10 and 18 may contribute to upregulation of CFTR gene transcription by forskolin and mitomycin C, respectively. dhs 36-39 CF transmembrane conductance regulator Homo sapiens 95-99 10561583-4 1999 We have now investigated further the DHS at -20.5 kb to evaluate its potential function in the regulation of CFTR expression. dhs 37-40 CF transmembrane conductance regulator Homo sapiens 109-113 10561583-10 1999 Thus, we provide evidence for a role for the -20.9 kb DHS in the transcriptional regulation of the CFTR gene, although the mechanisms mediating this effect remain unclear. dhs 54-57 CF transmembrane conductance regulator Homo sapiens 99-103 19782160-5 2009 Here we investigate DHS in introns 16 and 17a of the CFTR gene, which are evident in intestinal and pancreatic cell lines, and determine the transcription factors that interact with these sites. dhs 20-23 CF transmembrane conductance regulator Homo sapiens 53-57 19129223-4 2009 Here we focus on a DHS at +6.8 kb from the CFTR translation end-point to evaluate its potential role in regulating expression of the gene. dhs 19-22 CF transmembrane conductance regulator Homo sapiens 43-47 19129223-5 2009 This DHS, which encompasses a consensus CTCF-binding site, was evident in primary human epididymis cells that express abundant CFTR mRNA. dhs 5-8 CF transmembrane conductance regulator Homo sapiens 127-131 19129223-8 2009 Moreover, we reveal that in primary epididymis cells, the +6.8 kb DHS interacts closely with the CFTR promoter, suggesting that the CFTR locus exists in a looped conformation, characteristic of an active chromatin hub. dhs 66-69 CF transmembrane conductance regulator Homo sapiens 97-101 19129223-8 2009 Moreover, we reveal that in primary epididymis cells, the +6.8 kb DHS interacts closely with the CFTR promoter, suggesting that the CFTR locus exists in a looped conformation, characteristic of an active chromatin hub. dhs 66-69 CF transmembrane conductance regulator Homo sapiens 132-136