PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23603201-9 2013 This remarkable therapeutic effect of Saxagliptin mediated through DPP-4 inhibition demonstrates a unique mechanism for Abeta and tau clearance by increasing GLP-1 levels and reverses the behavioural deficits and pathology observed in AD. saxagliptin 38-49 glucagon Rattus norvegicus 158-163 34710367-10 2021 In addition, SAXA treatment increased the incretin hormones, glucagon like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP), which are linked to the activation of protein kinase B (AKT)/phosphatidylinositol3-kinase (PI3K) pathway. saxagliptin 13-17 glucagon Rattus norvegicus 61-84 34710367-10 2021 In addition, SAXA treatment increased the incretin hormones, glucagon like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP), which are linked to the activation of protein kinase B (AKT)/phosphatidylinositol3-kinase (PI3K) pathway. saxagliptin 13-17 glucagon Rattus norvegicus 86-91 34710367-11 2021 In conclusion, the current study revealed that the modulation of the interplay between the key events involved in depression, including oxidative stress, inflammation, and GLP-1/PI3K/AKT signaling pathway, can explain the anti-depressant activity of SAXA. saxagliptin 250-254 glucagon Rattus norvegicus 172-177