PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14654784-5	2003	Using either an artificial SMAD3/4-dependent reporter construct or the natural TGF-beta target, plasminogen activator inhibitor-1, we show that membrane-permeable dibutyryl cAMP, and other intracellular cAMP-elevating agents such as the phosphodiesterase inhibitor isobutyl-methylxanthine, the adenylate cyclase activator forskolin, or exogenous prostaglandin E2 (PGE2), interfere with TGF-beta-induced SMAD-specific gene transactivation.	Bucladesine	163-177	transforming growth factor beta 1	Homo sapiens	79-87	
2806770-6	1989	Moreover, the morphological effect of TGF-beta is observed in the presence of dibutyryl cyclic AMP (dbcAMP), which reduces the spreading of these cells.	Bucladesine	78-98	transforming growth factor beta 1	Homo sapiens	38-46	
2806770-6	1989	Moreover, the morphological effect of TGF-beta is observed in the presence of dibutyryl cyclic AMP (dbcAMP), which reduces the spreading of these cells.	Bucladesine	100-106	transforming growth factor beta 1	Homo sapiens	38-46	
14654784-5	2003	Using either an artificial SMAD3/4-dependent reporter construct or the natural TGF-beta target, plasminogen activator inhibitor-1, we show that membrane-permeable dibutyryl cAMP, and other intracellular cAMP-elevating agents such as the phosphodiesterase inhibitor isobutyl-methylxanthine, the adenylate cyclase activator forskolin, or exogenous prostaglandin E2 (PGE2), interfere with TGF-beta-induced SMAD-specific gene transactivation.	Bucladesine	163-177	transforming growth factor beta 1	Homo sapiens	386-394	
8166271-8	1994	Both forskolin (10 microM) and dibutyryl adenosine 3",5"-cyclic monophosphate (1 mM), but not phorbol 12-myristate 13-acetate (1 or 100 mM), were able to mimic ACTH actions in blunting the inhibitory effects of TGF-beta on DNA synthesis.	Bucladesine	31-77	transforming growth factor beta 1	Homo sapiens	211-219	
10935448-5	2000	In contrast, beta-catenin protein levels were reduced markedly in NTera2-N cells by exposure to dbcAMP, EGF or bFGF, and in U-373MG cells by treatment with dbcAMP or PMA, but were unaffected in any cell lines by BDNF, TNF-alpha, IL-1beta, IL-6, IFN-gamma or TGF-beta1.	Bucladesine	156-162	transforming growth factor beta 1	Homo sapiens	258-267	
11310848-10	2001	Furthermore, the effect of TGF-beta or indomethacin on blockage of TNF-alpha-stimulated MMP-9 production was reversed by the addition of either exogenous PGE2 or the cyclic AMP (cAMP) analogue Bt2cAMP.	Bucladesine	193-200	transforming growth factor beta 1	Homo sapiens	27-35	
10971321-5	2000	DBcAMP also stimulated fibroblast proliferation, resulting in further increases in IL-6 and TGF-beta1.	Bucladesine	0-6	transforming growth factor beta 1	Homo sapiens	92-101	
1373503-5	1992	To examine the mechanism of cAMP action in PC-3 cells, we tested the effect of the cAMP analog dibutyryl cAMP (Bt2-cAMP) on the regulation of the potent negative growth factor transforming growth factor beta (TGF-beta).	Bucladesine	111-119	transforming growth factor beta 1	Homo sapiens	209-217