PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9291836-12 1997 dbcAMP mimicked the effect of hCG on progesterone secretion by luteal tissue and luteal cells and oestradiol stimulated basal progesterone secretion in both small and large luteal cells. Bucladesine 0-6 chorionic gonadotropin subunit beta 5 Homo sapiens 30-33 12538609-8 2003 The differential regulation of the two beta-subunits by hCG could be mimicked by 3-isobutyl-1-methylxanthine, forskolin, and dibutyryl-cAMP, suggesting involvement of the intracellular cAMP pathway. Bucladesine 125-139 chorionic gonadotropin subunit beta 5 Homo sapiens 56-59 10788437-9 2000 Dideoxyadenosine and H-8 reversed the effect, and dibutyryl cAMP mimicked the effect, suggesting that hCG suppresses the transcription factors through cAMP-induced protein kinase A pathway. Bucladesine 50-64 chorionic gonadotropin subunit beta 5 Homo sapiens 102-105 9305807-6 1997 While hCG production in first-trimester trophoblast was increased by dibutyryl cyclic AMP and IL-1beta, both these effects may involve other factors such as IL-6, and their second messenger systems. Bucladesine 69-89 chorionic gonadotropin subunit beta 5 Homo sapiens 6-9 6309619-5 1983 hCG secretion was stimulated after 24-hr incubation with dibutyryl cAMP (100 microM) and by prostaglandin F1 alpha (10 microM). Bucladesine 57-71 chorionic gonadotropin subunit beta 5 Homo sapiens 0-3 2824633-1 1987 The effects of dibutyryl cyclic adenosine 3",5"-monophosphate (cAMP) and epidermal growth factor (EGF) on the synthesis and secretion of human chorionic gonadotropin (hCG) and its subunits by normal and malignant trophoblasts as well as by non-trophoblastic cells were investigated in vitro. Bucladesine 15-61 chorionic gonadotropin subunit beta 5 Homo sapiens 143-171 2999752-8 1985 The dbcAMP-stimulated placentae significantly increased their hCG output at both 48 and 72 hours. Bucladesine 4-10 chorionic gonadotropin subunit beta 5 Homo sapiens 62-65 2984496-3 1985 Normal cell morphology, basal hCG and hPL production and hCG responses to dibutyryl cAMP were preserved till 54 days of culture. Bucladesine 74-88 chorionic gonadotropin subunit beta 5 Homo sapiens 57-60 1376614-2 1992 When the cells were challenged with dibutryl cAMP (dbcAMP), forskolin or isobutylmethylxanthine, they produced significantly higher amounts of progesterone which in the presence of the hCG antibody was reduced to the level of the control set of cells. Bucladesine 51-57 chorionic gonadotropin subunit beta 5 Homo sapiens 185-188 1376614-7 1992 Neutralization of hCG by the antibodies, however, drastically reduced the LDL induced progesterone secretion, which was restored by the addition of dbcAMP to the medium. Bucladesine 148-154 chorionic gonadotropin subunit beta 5 Homo sapiens 18-21 1376614-9 1992 Since dbcAMP could mimic these actions of hCG, the data suggest a possible autocrine/paracrine role of hCG on the trophoblast cells. Bucladesine 6-12 chorionic gonadotropin subunit beta 5 Homo sapiens 42-45 1376614-9 1992 Since dbcAMP could mimic these actions of hCG, the data suggest a possible autocrine/paracrine role of hCG on the trophoblast cells. Bucladesine 6-12 chorionic gonadotropin subunit beta 5 Homo sapiens 103-106 2986550-3 1985 HCG (10 mIU/ml) or Bt2cAMP (1 mM) were then added to some of the cultures and the incubations were continued for up to 48 h. Testosterone production was increased markedly in cells incubated with hCG or Bt2cAMP. Bucladesine 19-26 chorionic gonadotropin subunit beta 5 Homo sapiens 196-199 2986550-3 1985 HCG (10 mIU/ml) or Bt2cAMP (1 mM) were then added to some of the cultures and the incubations were continued for up to 48 h. Testosterone production was increased markedly in cells incubated with hCG or Bt2cAMP. Bucladesine 203-210 chorionic gonadotropin subunit beta 5 Homo sapiens 196-199 2986550-10 1985 Since Bt2cAMP had effects similar to those observed with hCG, it is suggested that the stimulatory effects of hCG on the synthesis of cytochrome P-450scc and adrenodoxin are mediated by increased cyclic AMP formation. Bucladesine 6-13 chorionic gonadotropin subunit beta 5 Homo sapiens 110-113 6286293-10 1981 By adding 1 mM dibutyryl cyclic AMP to the perifusion medium, the release of both hCG and hCG-alpha was stimulated significantly. Bucladesine 15-35 chorionic gonadotropin subunit beta 5 Homo sapiens 82-85 163842-0 1975 Regulation of human chorionic gonadotropin (hCG) secretion by serum and dibutyryl cyclic AMP in malignant trophoblast cells in vitro. Bucladesine 72-92 chorionic gonadotropin subunit beta 5 Homo sapiens 20-48 195896-1 1977 The secretion of human chorionic gonadotropin (hCG) is stimulated by addition of N6, O2"-dibutyryl cyclic 3":5"-AMP (dbcAMP) or theophylline to normal term placenta and human malignant trophoblast cells in vitro. Bucladesine 81-115 chorionic gonadotropin subunit beta 5 Homo sapiens 47-50 195896-1 1977 The secretion of human chorionic gonadotropin (hCG) is stimulated by addition of N6, O2"-dibutyryl cyclic 3":5"-AMP (dbcAMP) or theophylline to normal term placenta and human malignant trophoblast cells in vitro. Bucladesine 117-123 chorionic gonadotropin subunit beta 5 Homo sapiens 47-50 195896-3 1977 Whereas dbcAMP was the most potent agent in stimulating secretion of hCG, the N6--and O2"-monobutyryl derivatives of cAMP and phosphodiesterase inhibitors (theophylline, papaverine, 3-isobutyl-1-methylxanthine) also increased the secretion of the hormone. Bucladesine 8-14 chorionic gonadotropin subunit beta 5 Homo sapiens 69-72 163842-3 1975 Incubation of the cells in the presence of serum, dbcAMP and theorphylline resulted in additive stimulation of hCG secretion after 1 day. Bucladesine 50-56 chorionic gonadotropin subunit beta 5 Homo sapiens 111-114