PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16740972-8 2006 Treatment of cytochalasin-D-treated cells with hormones and dbcAMP resulted in an increase in the secretion of IGF-binding protein-1 (IGFBP-1) and prolactin. Bucladesine 60-66 prolactin Homo sapiens 147-156 17272923-4 2007 When treated with the decidual stimulus dibutyryl-cAMP (db-cAMP) or forskolin, the fibroblastic cell-shaped EtsT cells transformed into large- and round-shaped cells and secreted large amounts of the decidual markers prolactin (PRL) and insulin-like growth factor binding protein-1 (IGFBP-1). Bucladesine 40-54 prolactin Homo sapiens 228-231 17272923-4 2007 When treated with the decidual stimulus dibutyryl-cAMP (db-cAMP) or forskolin, the fibroblastic cell-shaped EtsT cells transformed into large- and round-shaped cells and secreted large amounts of the decidual markers prolactin (PRL) and insulin-like growth factor binding protein-1 (IGFBP-1). Bucladesine 56-63 prolactin Homo sapiens 228-231 17272923-7 2007 It also abolished db-cAMP-induced PRL and IGFBP-1 mRNA expression and protein secretion. Bucladesine 18-25 prolactin Homo sapiens 34-37 16690806-3 2006 Treatment of human endometrial stromal cells with hormones (estradiol and medroxyprogesterone acetate) plus dibutyryl cAMP (H+dbcAMP) for 48 h increased expression of IGFBP1, PRL, TIMP3, CNR1, and DCN but not LAMB1, as measured by real-time PCR. Bucladesine 126-132 prolactin Homo sapiens 175-178 8404671-2 1993 PRL production under these conditions was demonstrated by documenting the synthesis of PRL mRNA (approximately 1.1 kilobase), the output of immunoprecipitable [35S]methionine-labeled PRL migrating as a single 23-kilodalton band during gel electrophoresis, and the time- and concentration-dependent secretion of PRL into the medium, measured by RIA (maximal on days 4-5 using 0.5 mM db-cAMP). Bucladesine 382-389 prolactin Homo sapiens 0-3 8752665-5 1996 Dibutyryl-cyclic AMP, a second messenger in prostaglandin signal transduction, was also synergistic with medroxyprogesterone acetate and E2, but induced significant PRL expression in the absence of the steroids (28 and 12 ng/72 h, respectively). Bucladesine 0-20 prolactin Homo sapiens 165-168 8752665-6 1996 The increase in PRL release was not a result of increased cell proliferation, because the PRL-secreting cultures had 32.2 +/- 8.8% less DNA (N = 3 individuals, 93% confidence limit) than control cultures after 3 weeks of treatment with dibutyryl-cyclic AMP, medroxyprogesterone acetate, and E2. Bucladesine 236-256 prolactin Homo sapiens 16-19 8752665-6 1996 The increase in PRL release was not a result of increased cell proliferation, because the PRL-secreting cultures had 32.2 +/- 8.8% less DNA (N = 3 individuals, 93% confidence limit) than control cultures after 3 weeks of treatment with dibutyryl-cyclic AMP, medroxyprogesterone acetate, and E2. Bucladesine 236-256 prolactin Homo sapiens 90-93 8404671-3 1993 Medroxyprogesterone acetate (1 microM) enhanced (1.7- to 2.5-fold) the effect of db-cAMP, 8-bromo-cAMP, or forskolin on PRL production, as evaluated by Western blotting analysis. Bucladesine 81-88 prolactin Homo sapiens 120-123 2482208-5 1989 The addition of dibutyryl cAMP caused a minor transient increase in hPRL secretion by 35% after 1 h. Bucladesine 16-30 prolactin Homo sapiens 68-72 2985726-2 1985 High K+ concentrations, hypothalamic extract, synthetic thyrotrophin-releasing hormone (TRH) and dibutyryl cyclic AMP (dbcAMP) all stimulated release of prolactin from control (non EGTA-treated) hemianterior pituitary glands. Bucladesine 119-125 prolactin Homo sapiens 153-162 2985726-8 1985 Although influx from the medium may be the major source of Ca2+, endogenous stores of Ca2+, perhaps mobilized by dbcAMP, may be able to maintain some release of prolactin. Bucladesine 113-119 prolactin Homo sapiens 161-170 2438170-1 1987 Exposure of human decidual cells for 0.5 h to dibutyryl cAMP, isobutyl-methylxanthine (IBMX), cholera toxin or forskolin caused a dose-dependent inhibition of prolactin release with maximal inhibition by each agent of 50-60%. Bucladesine 46-60 prolactin Homo sapiens 159-168