PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25847389-7 2015 Phosphorylation of CREB was inhibited in Crif1-knockdown BM-MSCs even in the presence of a PKA agonist (db-cAMP) and could be suppressed in Crif1-overexpressing BM-MSCs by a PKAalpha inhibitor (H-89). Bucladesine 104-111 cAMP responsive element binding protein 1 Homo sapiens 19-23 22695114-5 2012 The inhibitory effect of SP600125 could not be ascribed to the inhibition of PKA, since phosphorylation of CREB occurred in the presence of dbcAMP and SP600125. Bucladesine 140-146 cAMP responsive element binding protein 1 Homo sapiens 107-111 21266205-6 2011 SH-SY5Y cells co-transfected with CREB-expression vector increased dB-cAMP response in the wild type but not in the CRE-2 mutated plasmid; cotransfecting CREB-A (a dominant negative expression vector) strongly diminished basal or cAMP response. Bucladesine 67-74 cAMP responsive element binding protein 1 Homo sapiens 34-38 12959990-5 2003 Our results showed that STC mRNA induction by dbcAMP was mediated by protein kinase A-cAMP response element binding protein (CREB) pathway, accompanied with phosphorylation of CREB and a reduction of p50, p65, and phosphorylated inhibitor kappaBalpha levels. Bucladesine 46-52 cAMP responsive element binding protein 1 Homo sapiens 84-123 12959990-5 2003 Our results showed that STC mRNA induction by dbcAMP was mediated by protein kinase A-cAMP response element binding protein (CREB) pathway, accompanied with phosphorylation of CREB and a reduction of p50, p65, and phosphorylated inhibitor kappaBalpha levels. Bucladesine 46-52 cAMP responsive element binding protein 1 Homo sapiens 125-129 12959990-5 2003 Our results showed that STC mRNA induction by dbcAMP was mediated by protein kinase A-cAMP response element binding protein (CREB) pathway, accompanied with phosphorylation of CREB and a reduction of p50, p65, and phosphorylated inhibitor kappaBalpha levels. Bucladesine 46-52 cAMP responsive element binding protein 1 Homo sapiens 176-180 8065321-4 1994 In HepG2 cells expressing small t, dibutyryl-cAMP (Bt2cAMP) stimulated the phosphorylation of CREB 65-fold, whereas CREB phosphorylation was stimulated only 5- to 8-fold by Bt2cAMP in cells not expressing small t. Small t also inhibited the dephosphorylation of cAMP-dependent protein kinase (PKA)-phosphorylated CREB in rat liver nuclear extracts. Bucladesine 51-58 cAMP responsive element binding protein 1 Homo sapiens 94-98 8065321-7 1994 These data suggest that small t enhances Bt2cAMP-stimulated gene transcription by inhibiting the dephosphorylation of PKA-phosphorylated CREB by nuclear PP2A. Bucladesine 41-48 cAMP responsive element binding protein 1 Homo sapiens 137-141 18057713-4 2007 Enhanced CRE promoter activities in HuH-7 cells treated with dibutyryl cAMP or co-transfected with a protein kinase A expression vector pFC-PKA that enhances the phosphorylation of CRE binding protein (CREB) were suppressed by PUGNAc. Bucladesine 61-75 cAMP responsive element binding protein 1 Homo sapiens 181-200 18057713-4 2007 Enhanced CRE promoter activities in HuH-7 cells treated with dibutyryl cAMP or co-transfected with a protein kinase A expression vector pFC-PKA that enhances the phosphorylation of CRE binding protein (CREB) were suppressed by PUGNAc. Bucladesine 61-75 cAMP responsive element binding protein 1 Homo sapiens 202-206 14607516-2 2003 We found that cAMP response element-binding protein (CREB) is cleaved during iron chelator deferoxamine (DFO)-induced apoptosis, and that the cleavage is largely prevented by the cell-permeable analog of cAMP, dibutyryl-cAMP (dbcAMP), a known CREB activator. Bucladesine 210-224 cAMP responsive element binding protein 1 Homo sapiens 14-51 14607516-2 2003 We found that cAMP response element-binding protein (CREB) is cleaved during iron chelator deferoxamine (DFO)-induced apoptosis, and that the cleavage is largely prevented by the cell-permeable analog of cAMP, dibutyryl-cAMP (dbcAMP), a known CREB activator. Bucladesine 210-224 cAMP responsive element binding protein 1 Homo sapiens 53-57 14607516-2 2003 We found that cAMP response element-binding protein (CREB) is cleaved during iron chelator deferoxamine (DFO)-induced apoptosis, and that the cleavage is largely prevented by the cell-permeable analog of cAMP, dibutyryl-cAMP (dbcAMP), a known CREB activator. Bucladesine 226-232 cAMP responsive element binding protein 1 Homo sapiens 14-51 14607516-2 2003 We found that cAMP response element-binding protein (CREB) is cleaved during iron chelator deferoxamine (DFO)-induced apoptosis, and that the cleavage is largely prevented by the cell-permeable analog of cAMP, dibutyryl-cAMP (dbcAMP), a known CREB activator. Bucladesine 226-232 cAMP responsive element binding protein 1 Homo sapiens 53-57 14607516-5 2003 dbcAMP by itself rapidly induced CREB phosphorylation but dramatically inhibited DFO-induced phosphorylation of all three MAPK family members. Bucladesine 0-6 cAMP responsive element binding protein 1 Homo sapiens 33-37 14607516-6 2003 However, disruption of CREB expression by antisense oligodeoxyribonucleotide (AS-ODN) only restored p38 kinase activation, and simultaneously attenuated dbcAMP-induced protection of HL-60 cells from DFO-induced cell death. Bucladesine 153-159 cAMP responsive element binding protein 1 Homo sapiens 23-27 12606779-6 2003 The cell-permeable cAMP analog dibutyryl cAMP partially and almost simultaneously suppressed all of these CT105-induced signaling pathways through excessive CREB phosphorylation, which led to decreased CREB DNA binding activity and reduced TNF-alpha expression. Bucladesine 31-45 cAMP responsive element binding protein 1 Homo sapiens 157-161 12606779-6 2003 The cell-permeable cAMP analog dibutyryl cAMP partially and almost simultaneously suppressed all of these CT105-induced signaling pathways through excessive CREB phosphorylation, which led to decreased CREB DNA binding activity and reduced TNF-alpha expression. Bucladesine 31-45 cAMP responsive element binding protein 1 Homo sapiens 202-206 12091337-7 2002 Activation of the cAMP pathway resulted in cAMP-response element binding protein (CREB) phosphorylation, which was sustained in the presence of EPO plus PGE2 and transient on EPO stimulation alone. Bucladesine 18-22 cAMP responsive element binding protein 1 Homo sapiens 43-80 12091337-7 2002 Activation of the cAMP pathway resulted in cAMP-response element binding protein (CREB) phosphorylation, which was sustained in the presence of EPO plus PGE2 and transient on EPO stimulation alone. Bucladesine 18-22 cAMP responsive element binding protein 1 Homo sapiens 82-86 12091337-11 2002 In summary, these studies demonstrate that PGE2 enhancement of EPO-induced STAT5 transactivation is mediated by the cAMP/PKA/CREB pathway. Bucladesine 116-120 cAMP responsive element binding protein 1 Homo sapiens 125-129 11752056-5 2001 The negative forms of CREB and c-Fos inhibited neurite outgrowth mediated by NCAM, arachidonic acid, dBcAMP, or MEK2. Bucladesine 101-107 cAMP responsive element binding protein 1 Homo sapiens 22-26