PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19371952-4 2009 Both forskolin (a direct activator of adenylyl cyclase) and dibutyryl-cAMP (DBcAMP, a permeable analog of cAMP) suppressed production of TARC and MDC in parallel with the activation of NF-kappaB in IFN-gamma and TNF-alpha-stimulated HaCaT cells. Bucladesine 76-82 interferon gamma Homo sapiens 198-207 19371952-8 2009 Of note, the IFN-gamma plus TNF-alpha-stimulated activation of p38 MAPK was suppressed following incubation with forskolin or DBcAMP alone. Bucladesine 126-132 interferon gamma Homo sapiens 13-22 11602691-2 2001 Addition of dibutyryl cAMP mimicked rolipram inhibitions on proliferation, IL-2, TNF-alpha, and IFN-gamma but not on IL-10 or IL-5 production. Bucladesine 12-26 interferon gamma Homo sapiens 96-105 11193379-14 2000 Similarly, dbcAMP inhibited the production of IFN-gamma and IL-2 more potently than that of IL-4 and IL-5. Bucladesine 11-17 interferon gamma Homo sapiens 46-55 9878122-5 1998 Data demonstrated a significant inhibition of IL-17 as well as of IFN-gamma mRNA expression in CD8(+) T cells isolated from activated PBMC cultured in the presence of either dibutyryl cAMP (db-cAMP) or PGE2. Bucladesine 190-197 interferon gamma Homo sapiens 66-75 10935448-5 2000 In contrast, beta-catenin protein levels were reduced markedly in NTera2-N cells by exposure to dbcAMP, EGF or bFGF, and in U-373MG cells by treatment with dbcAMP or PMA, but were unaffected in any cell lines by BDNF, TNF-alpha, IL-1beta, IL-6, IFN-gamma or TGF-beta1. Bucladesine 156-162 interferon gamma Homo sapiens 245-254 9502171-8 1998 Similarly, dbcAMP inhibited the production of IFN-gamma and IL-2 more potently than IL-4 and IL-5. Bucladesine 11-17 interferon gamma Homo sapiens 46-55 9818793-8 1998 Finally, elevation of intracellular cAMP levels by dbcAMP treatment consistently inhibited IL-12 as well as IL-10 production in monocytes induced by IFN-gamma or IFN-gamma plus 25 mM ethanol. Bucladesine 51-57 interferon gamma Homo sapiens 149-158 9818793-8 1998 Finally, elevation of intracellular cAMP levels by dbcAMP treatment consistently inhibited IL-12 as well as IL-10 production in monocytes induced by IFN-gamma or IFN-gamma plus 25 mM ethanol. Bucladesine 51-57 interferon gamma Homo sapiens 162-171 3031123-4 1987 However, when TSH or DBcAMP was added after the cells had been cultured for 4 days with IFN gamma, T3 and thyroglobulin secretion in response to both 10 mU/mL TSH and 1 mM DBcAMP was significantly inhibited. Bucladesine 21-27 interferon gamma Homo sapiens 88-97 9301524-5 1997 This differential regulation of IFN-gamma and IL-10 expression was related to intracellular cAMP concentration. Bucladesine 92-96 interferon gamma Homo sapiens 32-41 9301524-7 1997 We developed a new method based on immunofluorescence for intracellular cytokine detection followed by optical and computerized image processing, and our results showed that IFN-gamma protein was strongly inhibited when cells were treated with PGE2 or dibutyryl (db)-cAMP, whereas IL-10 protein was enhanced. Bucladesine 267-271 interferon gamma Homo sapiens 174-183 7541446-5 1995 Treatment with interferon-beta (IFN-beta), platelet-derived growth factor-AA, leukemia inhibitory factor, phorbol 12-myristate 13-acetate, and dibutyryl cyclic AMP stimulated phosphorylation of HSP27 moderately, while IFN-gamma, TNF-beta, basic fibroblast growth factor, epidermal growth factor, or fetal bovine serum did not significantly alter the level of HSP27 phosphorylation. Bucladesine 143-163 interferon gamma Homo sapiens 218-227 7982855-7 1994 Contrary to its enhancing effect on Fc gamma RII expression, dbcAMP suppressed the IFN-gamma-induced Fc gamma RIII expression on peripheral eosinophils. Bucladesine 61-67 interferon gamma Homo sapiens 83-92 8394282-3 1993 Pretreatment of EoL-1 cells with dbcAMP induced EoL-1 cells to express Fc gamma RIII when stimulated with IFN-gamma, but EoL-1 cells pretreated with IFN-gamma and then stimulated with dbcAMP failed to express Fc gamma RIII. Bucladesine 33-39 interferon gamma Homo sapiens 106-115 8391076-5 1993 The inhibition of M phi metalloproteinase production by IFN-gamma and IL-4 was reversed by PGE2 or Bt2cAMP. Bucladesine 99-106 interferon gamma Homo sapiens 56-65 2472285-3 1989 The inhibitory effect of the trypsin inhibitors is similar to that of glucocorticoids in that it is a transient event, fading with length of exposure to IFN-gamma, and is reversed by the addition of dibutyryl cyclic AMP (dbcAMP) and phospholipase C(PLC) from Clostridium perfringens. Bucladesine 221-227 interferon gamma Homo sapiens 153-162 2472285-4 1989 In H12 cells, dbcAMP and PLC enhance the IFN-gamma induction of HLA-DR, but do not induce in the absence of INF-gamma. Bucladesine 14-20 interferon gamma Homo sapiens 41-50 9301524-2 1997 In the present work, we attempted to clarify the role of cAMP on interferon-gamma (IFN-gamma), interleukin (IL)-10, IL-4 and IL-13 expression as well as on the inducible nitric oxide synthase (iNOS) expression. Bucladesine 57-61 interferon gamma Homo sapiens 65-81 9301524-2 1997 In the present work, we attempted to clarify the role of cAMP on interferon-gamma (IFN-gamma), interleukin (IL)-10, IL-4 and IL-13 expression as well as on the inducible nitric oxide synthase (iNOS) expression. Bucladesine 57-61 interferon gamma Homo sapiens 83-92 9301524-3 1997 Treatment of phytohaemagglutinin (PHA)/phorbol 12-myristate 13-acetate (PMA)-activated Jurkat cells with either dibutyryl-cyclic adenosine monophosphate (cAMP) or pentoxifylline induced a strong inhibition of IFN-gamma mRNA expression as measured by reverse transcription (RT)-polymerase chain reaction (PCR), without affecting IL-10 expression. Bucladesine 112-152 interferon gamma Homo sapiens 209-218 8388062-5 1993 dbcAMP suppressed the IFN-gamma-induced Fc gamma R III expression on peripheral eosinophils. Bucladesine 0-6 interferon gamma Homo sapiens 22-31 6088631-8 1984 In contrast to their effectiveness on macrophages, prostaglandin E2 and dibutyryl cyclic AMP only slightly inhibited the induction of Ia antigens on TDMC by IFN-gamma, whereas endotoxin (1 to 60 micrograms/ml) had no effect. Bucladesine 72-92 interferon gamma Homo sapiens 157-166