PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14654784-5	2003	Using either an artificial SMAD3/4-dependent reporter construct or the natural TGF-beta target, plasminogen activator inhibitor-1, we show that membrane-permeable dibutyryl cAMP, and other intracellular cAMP-elevating agents such as the phosphodiesterase inhibitor isobutyl-methylxanthine, the adenylate cyclase activator forskolin, or exogenous prostaglandin E2 (PGE2), interfere with TGF-beta-induced SMAD-specific gene transactivation.	Bucladesine	163-177	serpin family E member 1	Homo sapiens	96-129	
21496886-0	2011	Effect of dibutyryl cyclic adenosine monophosphate on the gene expression of plasminogen activator inhibitor-1 and tissue factor in adipocytes.	Bucladesine	10-50	serpin family E member 1	Homo sapiens	77-110	
21496886-3	2011	Here, we investigate the effect of dibutyryl-cAMP (a phosphodiesterase-resistant analog of cAMP) on the gene expression of PAI-1 and TF in adipocytes.	Bucladesine	35-49	serpin family E member 1	Homo sapiens	123-128	
21496886-7	2011	However, PAI-1 gene expression was slightly but significantly increased by dibutyryl-cAMP.	Bucladesine	75-89	serpin family E member 1	Homo sapiens	9-14	
2545266-2	1989	Significant inhibition of baseline (unstimulated) t-PA and PAI-1 secretion was observed in response to several agents which, when added exogenously, cause increased intracellular cAMP: cholera toxin, 1-methyl-3-isobutylxanthine (MIX), dibutyryl-cAMP, and prostaglandin E1.	Bucladesine	235-249	serpin family E member 1	Homo sapiens	59-64	
7718621-4	1995	PA inhibitor-1 (PAI-1) antigen was inhibited by dbcAMP or forskolin.	Bucladesine	48-54	serpin family E member 1	Homo sapiens	0-14	
10397697-7	1999	However, simultaneous activation of protein kinase C by PMA and cAMP-dependent protein kinase by dBu-cAMP only slightly attenuated PMA-induced PAI-1 increase.	Bucladesine	97-105	serpin family E member 1	Homo sapiens	143-148	
11246817-6	2000	Moreover, addition of cAMP-elevating agents such as dibutyryl-cAMP, forskolin and the phosphodiesterase inhibitors isobutyl-methylxanthine and milrinone resulted in a reduction of PAI-1 of varying degrees.	Bucladesine	52-66	serpin family E member 1	Homo sapiens	180-185	
9867210-6	1998	Further, it was found that AGE decreased the intracellular cyclic AMP concentrations in EC and that cyclic AMP agonists such as dibutyryl cyclic AMP, forskolin and PGI2 analogue reduced the AGE-stimulated PAI-1 production, suggesting the involvement of cyclic AMP in the AGE-signalling pathway.	Bucladesine	128-148	serpin family E member 1	Homo sapiens	205-210	
7718621-4	1995	PA inhibitor-1 (PAI-1) antigen was inhibited by dbcAMP or forskolin.	Bucladesine	48-54	serpin family E member 1	Homo sapiens	16-21