PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10102384-6	1998	These results indicate that DMSO induced increase of LT synthesis is associated with the increase of mRNA expression of 5-LO, LTC4 synthase and LTA4 hydrolase, although the precise regulatory mechanisms of the increased mRNA expression are not determined.	Dimethyl Sulfoxide	28-32	leukotriene C4 synthase	Homo sapiens	126-139	
15002759-8	2004	The DMSO-induced mRNA expression and enzyme activity of LTC4 synthase was also suppressed by DSCG.	Dimethyl Sulfoxide	4-8	leukotriene C4 synthase	Homo sapiens	56-69	
15002759-9	2004	CONCLUSIONS: Our results indicate that DSCG suppresses the DMSO-induced LTC4 synthase-activity by inhibiting mRNA expression of LTC4 synthase, which might be a novel anti-allergic action of DSCG.	Dimethyl Sulfoxide	59-63	leukotriene C4 synthase	Homo sapiens	72-85	
15002759-9	2004	CONCLUSIONS: Our results indicate that DSCG suppresses the DMSO-induced LTC4 synthase-activity by inhibiting mRNA expression of LTC4 synthase, which might be a novel anti-allergic action of DSCG.	Dimethyl Sulfoxide	59-63	leukotriene C4 synthase	Homo sapiens	128-141	
10102384-9	1998	The DEX attenuated the DMSO-induced increase of mRNA expression for LTC4 synthase, but showed no effect on that for LTA4 hydrolase.	Dimethyl Sulfoxide	23-27	leukotriene C4 synthase	Homo sapiens	68-81	
1425677-0	1992	Purification of human leukotriene C4 synthase from dimethylsulfoxide-differentiated U937 cells.	Dimethyl Sulfoxide	51-68	leukotriene C4 synthase	Homo sapiens	22-45	
1472015-8	1992	The present report describes the induction of LTC4 synthase activity during differentiation of human erythroleukemia (HEL) cells by the protein kinase C stimulator 12-O-tetradecanoyl phorbol 13-acetate (TPA), ligands of the steroid-thyroid hormone receptor superfamily: all-trans-retinoic acid (RA) and 1 alpha, 25-dihydroxy-vitamin D3 and in addition dimethylsulfoxide (DMSO).	Dimethyl Sulfoxide	352-369	leukotriene C4 synthase	Homo sapiens	46-59	
1472015-8	1992	The present report describes the induction of LTC4 synthase activity during differentiation of human erythroleukemia (HEL) cells by the protein kinase C stimulator 12-O-tetradecanoyl phorbol 13-acetate (TPA), ligands of the steroid-thyroid hormone receptor superfamily: all-trans-retinoic acid (RA) and 1 alpha, 25-dihydroxy-vitamin D3 and in addition dimethylsulfoxide (DMSO).	Dimethyl Sulfoxide	371-375	leukotriene C4 synthase	Homo sapiens	46-59	
8425605-1	1993	Human leukotriene C4 synthase specific activity in the human monocytic leukemia cell line THP-1 (0.302 +/- 0.062 nmol LTC4 formed.min-1 x mg-1) was 7.6-fold higher than in U937 cells (0.040 +/- 0.017 nmol LTC4 formed.min-1 x mg-1) and comparable to dimethylsulfoxide-differentiated U937 cells (0.399 +/- 0.084 nmol LTC4 formed.min-1 x mg-1).	Dimethyl Sulfoxide	249-266	leukotriene C4 synthase	Homo sapiens	6-29	
1425677-1	1992	Human leukotriene C4 (LTC4) synthase was purified > 10000-fold from dimethylsulfoxide-differentiated U937 cells.	Dimethyl Sulfoxide	71-88	leukotriene C4 synthase	Homo sapiens	6-36	
1517222-9	1992	Elevation of both the level of the specifically photolabeled 18-kDa polypeptide and of LTC4 synthase specific activity occurred concomitantly with dimethyl sulfoxide differentiation of U937 cells.	Dimethyl Sulfoxide	147-165	leukotriene C4 synthase	Homo sapiens	87-100	
1517222-0	1992	Human leukotriene C4 synthase expression in dimethyl sulfoxide-differentiated U937 cells.	Dimethyl Sulfoxide	44-62	leukotriene C4 synthase	Homo sapiens	6-29	
1517222-1	1992	Leukotriene C4 (LTC4) synthase was highly expressed in the human U937 monoblast leukemia cell line when differentiated into monocyte/macrophage-like cells by growth in the presence of dimethyl sulfoxide.	Dimethyl Sulfoxide	184-202	leukotriene C4 synthase	Homo sapiens	0-30	
1517222-3	1992	The increase in LTC4 synthase activity following dimethyl sulfoxide-induced differentiation was substantially higher than the increase observed for other proteins involved in leukotriene biosynthesis.	Dimethyl Sulfoxide	49-67	leukotriene C4 synthase	Homo sapiens	16-29	
1517222-5	1992	The HL-60 myeloblast leukemia cell line expressed higher LTC4 synthase levels when differentiated into either neutrophil-like or macrophage-like cells by growth in the presence of dimethyl sulfoxide or phorbol 12-myristate 13-acetate (respectively), but reached a specific activity comparable only to undifferentiated U937 cells.	Dimethyl Sulfoxide	180-198	leukotriene C4 synthase	Homo sapiens	57-70	
1517222-7	1992	An 18-kDa polypeptide was specifically labeled in membranes from dimethyl sulfoxide-differentiated U937 cells using azido 125I-LTC4, a photoaffinity probe based on the product of the LTC4 synthase-catalyzed reaction.	Dimethyl Sulfoxide	65-83	leukotriene C4 synthase	Homo sapiens	183-196	
1517222-10	1992	We conclude that differentiation of U937 cells into monocyte/macrophage-like cells by growth in the presence of dimethyl sulfoxide results in high levels of expression of LTC4 synthase activity.	Dimethyl Sulfoxide	112-130	leukotriene C4 synthase	Homo sapiens	171-184