PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2501036-1 1989 The murine erythroleukemia (MEL) cell line, TSA8, becomes responsive to erythropoietin after induction with dimethyl sulfoxide (DMSO). Dimethyl Sulfoxide 108-126 erythropoietin Mus musculus 72-86 2501036-1 1989 The murine erythroleukemia (MEL) cell line, TSA8, becomes responsive to erythropoietin after induction with dimethyl sulfoxide (DMSO). Dimethyl Sulfoxide 128-132 erythropoietin Mus musculus 72-86 2553385-3 1989 TSA8 cells become responsive to erythropoietin after induction with DMSO. Dimethyl Sulfoxide 68-72 erythropoietin Mus musculus 32-46 2832053-0 1988 Induction of the receptor for erythropoietin in murine erythroleukemia cells after dimethyl sulfoxide treatment. Dimethyl Sulfoxide 83-101 erythropoietin Mus musculus 30-44 2832053-3 1988 During erythroid differentiation by dimethyl sulfoxide, B8 cells displayed a rapid and marked increase in the amount of specific 125I-EPO binding before the appearance of hemoglobin-containing cells. Dimethyl Sulfoxide 36-54 erythropoietin Mus musculus 134-137 2832053-5 1988 In addition, the number of EPO receptors on B8 cells was increased twice by induction with DMSO for 1 day, but the binding affinity of EPO toward its receptors did not change significantly. Dimethyl Sulfoxide 91-95 erythropoietin Mus musculus 27-30 9778688-0 1998 Role of gp55 in restoring the sensitivity of Friend murine erythroleukemia cells to erythropoietin by exposure to dimethyl sulfoxide. Dimethyl Sulfoxide 114-132 erythropoietin Mus musculus 84-98 25708005-7 2015 Although almost no differences among the studied cryoprotectant solutions were observed on the differentiation potential of encapsulated mesenchymal stem cells, the penetrating cryoprotectant DMSO at a concentration of 10% displayed the best viability and erythropoietin secretion profile compared to the other cryoprotectant solutions. Dimethyl Sulfoxide 192-196 erythropoietin Mus musculus 256-270 2835222-1 1987 On addition of DMSO, the MEL cell line TSA8 becomes committed into erythroid progenitor cells (CFU-E) which can form differentiated colonies in the presence of erythropoietin. Dimethyl Sulfoxide 15-19 erythropoietin Mus musculus 160-174 9778688-3 1998 Dimethyl sulfoxide (DMSO) induced the differentiation of MEL cells and partially restored responsiveness to Epo, with both increased proliferation and further hemoglobin synthesis. Dimethyl Sulfoxide 0-18 erythropoietin Mus musculus 108-111 9778688-3 1998 Dimethyl sulfoxide (DMSO) induced the differentiation of MEL cells and partially restored responsiveness to Epo, with both increased proliferation and further hemoglobin synthesis. Dimethyl Sulfoxide 20-24 erythropoietin Mus musculus 108-111 9778688-4 1998 Treatment of MEL cells with DMSO caused a decrease in the cellular content of gp55 as measured by Western analysis and an increase in the level of the EpoR as measured by [125I]Epo binding. Dimethyl Sulfoxide 28-32 erythropoietin Mus musculus 151-154 9778688-7 1998 An increase in the level of gp55 interfered with the ability of DMSO to restore sensitivity to Epo, whereas a decrease in the level of gp55 increased the Epo-sensitizing effects of DMSO. Dimethyl Sulfoxide 64-68 erythropoietin Mus musculus 95-98 9778688-7 1998 An increase in the level of gp55 interfered with the ability of DMSO to restore sensitivity to Epo, whereas a decrease in the level of gp55 increased the Epo-sensitizing effects of DMSO. Dimethyl Sulfoxide 181-185 erythropoietin Mus musculus 154-157 9778688-9 1998 DMSO treatment caused an increase in the level of [125I]Epo cross-linking. Dimethyl Sulfoxide 0-4 erythropoietin Mus musculus 56-59 9778688-11 1998 The finding of a decrease in the cellular content of gp55, an increase in the level of the EpoR, and an increase in the formation of the Epo/EpoR complex is consistent with the acquisition of sensitivity to Epo by MEL cells following treatment with DMSO. Dimethyl Sulfoxide 249-253 erythropoietin Mus musculus 91-94 9778688-11 1998 The finding of a decrease in the cellular content of gp55, an increase in the level of the EpoR, and an increase in the formation of the Epo/EpoR complex is consistent with the acquisition of sensitivity to Epo by MEL cells following treatment with DMSO. Dimethyl Sulfoxide 249-253 erythropoietin Mus musculus 137-140 2175220-0 1990 Potentiation of the erythropoietin response by dimethyl sulfoxide priming of erythroleukemia cells: evidence for interaction of two signaling pathways. Dimethyl Sulfoxide 47-65 erythropoietin Mus musculus 20-34 1848708-0 1991 Erythropoietin receptors induced by dimethyl sulfoxide exhibit positive cooperativity associated with an amplified biologic response. Dimethyl Sulfoxide 36-54 erythropoietin Mus musculus 0-14 2175220-4 1990 Pretreatment of these cells for 1 day with DMSO followed by its removal and the addition of Epo resulted in a marked enhancement of the Epo specific hemoglobinization. Dimethyl Sulfoxide 43-47 erythropoietin Mus musculus 136-139 2175220-6 1990 This priming effect of DMSO on the Epo response was both time-dependent and DMSO concentration-dependent. Dimethyl Sulfoxide 23-27 erythropoietin Mus musculus 35-38 2175220-6 1990 This priming effect of DMSO on the Epo response was both time-dependent and DMSO concentration-dependent. Dimethyl Sulfoxide 76-80 erythropoietin Mus musculus 35-38 2175220-7 1990 DMSO priming potentiated the Epo response in three ways. Dimethyl Sulfoxide 0-4 erythropoietin Mus musculus 29-32 2175220-8 1990 Firstly, DMSO priming increased the total number of Epo responsive cells from 8% to 10% to 40% to 60%. Dimethyl Sulfoxide 9-13 erythropoietin Mus musculus 52-55 2175220-9 1990 Secondly, DMSO priming reduced the time required to reach the optimal Epo-induced response from 4 days to 2 days. Dimethyl Sulfoxide 10-14 erythropoietin Mus musculus 70-73 2175220-11 1990 DMSO priming was also associated with a marked increase in Epo receptor density characterized by an apparently new receptor population and by the appearance of positive cooperativity between receptors. Dimethyl Sulfoxide 0-4 erythropoietin Mus musculus 59-62 2175220-12 1990 Our results suggest that the DMSO priming effect is due to potentiation of the Epo signaling pathway, thus resulting in a much more rapid and dramatic Epo-induced hemoglobinization response. Dimethyl Sulfoxide 29-33 erythropoietin Mus musculus 79-82 2175220-12 1990 Our results suggest that the DMSO priming effect is due to potentiation of the Epo signaling pathway, thus resulting in a much more rapid and dramatic Epo-induced hemoglobinization response. Dimethyl Sulfoxide 29-33 erythropoietin Mus musculus 151-154