PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29789998-6 2018 Pro-inflammatory cytokine TNFalpha also induced AX800134 upregulation in HBx-expressing HepG2 cells, which could be reversed by reactive oxygen species (ROS) scavenger pyrrolidine dithiocarbamate (PDTC). pyrrolidine dithiocarbamic acid 168-195 tumor necrosis factor Homo sapiens 26-34 30915775-10 2019 The NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) reduced the behavioral abnormalities caused by ceramide accumulation, downregulated CONCLUSIONS: The experimental results suggest that ceramide reduces EAAT-2 expression through the NF-kappaB/TNF-alpha pathway and causes neuronal excitotoxicity in the pathogenesis of schizophrenia, leading to neuronal damage. pyrrolidine dithiocarbamic acid 24-51 tumor necrosis factor Homo sapiens 251-260 30915775-10 2019 The NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) reduced the behavioral abnormalities caused by ceramide accumulation, downregulated CONCLUSIONS: The experimental results suggest that ceramide reduces EAAT-2 expression through the NF-kappaB/TNF-alpha pathway and causes neuronal excitotoxicity in the pathogenesis of schizophrenia, leading to neuronal damage. pyrrolidine dithiocarbamic acid 53-57 tumor necrosis factor Homo sapiens 251-260 29789998-6 2018 Pro-inflammatory cytokine TNFalpha also induced AX800134 upregulation in HBx-expressing HepG2 cells, which could be reversed by reactive oxygen species (ROS) scavenger pyrrolidine dithiocarbamate (PDTC). pyrrolidine dithiocarbamic acid 197-201 tumor necrosis factor Homo sapiens 26-34 29545865-7 2018 Investigation of molecular mechanism revealed that the pretreatment with liquiritin and pyrrolidinedithiocarbamic acid (PDTC) obviously blocked the expression of NF-kappaB p65 in nuclear protein increased by oxybuprocaine and the expression levels of total proteins, caspase-3 and Bax.Moreover, tumor necrosis factor-alpha (TNF-alpha) blocked the inhibitory effect of liquiritin on the expression of NF-kappaB p65 in nuclear protein and total proteins, caspase-3 and Bax, thus obstructing the protective effect of liquiritin on corneal epithelial cells. pyrrolidine dithiocarbamic acid 88-118 tumor necrosis factor Homo sapiens 295-322 28946816-8 2018 The NFkappaB participation in TNF-alpha effect on adiponectin expression was assayed using an NFkappaB inhibitor (pyrrolidine dithiocarbamate). pyrrolidine dithiocarbamic acid 114-141 tumor necrosis factor Homo sapiens 30-39 29545865-7 2018 Investigation of molecular mechanism revealed that the pretreatment with liquiritin and pyrrolidinedithiocarbamic acid (PDTC) obviously blocked the expression of NF-kappaB p65 in nuclear protein increased by oxybuprocaine and the expression levels of total proteins, caspase-3 and Bax.Moreover, tumor necrosis factor-alpha (TNF-alpha) blocked the inhibitory effect of liquiritin on the expression of NF-kappaB p65 in nuclear protein and total proteins, caspase-3 and Bax, thus obstructing the protective effect of liquiritin on corneal epithelial cells. pyrrolidine dithiocarbamic acid 120-124 tumor necrosis factor Homo sapiens 295-322 29545865-7 2018 Investigation of molecular mechanism revealed that the pretreatment with liquiritin and pyrrolidinedithiocarbamic acid (PDTC) obviously blocked the expression of NF-kappaB p65 in nuclear protein increased by oxybuprocaine and the expression levels of total proteins, caspase-3 and Bax.Moreover, tumor necrosis factor-alpha (TNF-alpha) blocked the inhibitory effect of liquiritin on the expression of NF-kappaB p65 in nuclear protein and total proteins, caspase-3 and Bax, thus obstructing the protective effect of liquiritin on corneal epithelial cells. pyrrolidine dithiocarbamic acid 120-124 tumor necrosis factor Homo sapiens 324-333 29545865-7 2018 Investigation of molecular mechanism revealed that the pretreatment with liquiritin and pyrrolidinedithiocarbamic acid (PDTC) obviously blocked the expression of NF-kappaB p65 in nuclear protein increased by oxybuprocaine and the expression levels of total proteins, caspase-3 and Bax.Moreover, tumor necrosis factor-alpha (TNF-alpha) blocked the inhibitory effect of liquiritin on the expression of NF-kappaB p65 in nuclear protein and total proteins, caspase-3 and Bax, thus obstructing the protective effect of liquiritin on corneal epithelial cells. pyrrolidine dithiocarbamic acid 88-118 tumor necrosis factor Homo sapiens 324-333 28488777-5 2018 Pyrrolidinedithiocarbamic acid (PDTC, 60 microM), a specific NF-kappaB inhibitor, abated NF-kappaB activation that rendered the adipocytes vulnerable to TNFalpha-induced apoptosis. pyrrolidine dithiocarbamic acid 0-30 tumor necrosis factor Homo sapiens 153-161 28488777-5 2018 Pyrrolidinedithiocarbamic acid (PDTC, 60 microM), a specific NF-kappaB inhibitor, abated NF-kappaB activation that rendered the adipocytes vulnerable to TNFalpha-induced apoptosis. pyrrolidine dithiocarbamic acid 32-36 tumor necrosis factor Homo sapiens 153-161 28634844-8 2017 Additional experiments showed that Pyrrolidine dithiocarbamate (PDTC) inhibited IL-6, IL-1beta, and TNF-alpha expression induced by overexpression of TSP-1, accompanying with downregulation of phosphorylated p65 and IkappaBalpha protein levels in response to P. gingivalis LPS. pyrrolidine dithiocarbamic acid 35-62 tumor necrosis factor Homo sapiens 100-109 28634844-8 2017 Additional experiments showed that Pyrrolidine dithiocarbamate (PDTC) inhibited IL-6, IL-1beta, and TNF-alpha expression induced by overexpression of TSP-1, accompanying with downregulation of phosphorylated p65 and IkappaBalpha protein levels in response to P. gingivalis LPS. pyrrolidine dithiocarbamic acid 64-68 tumor necrosis factor Homo sapiens 100-109 27925186-8 2017 TNF-alpha did not change p-ERK1/2 levels, but increased the phosphorylation and nuclear localization of nuclear factor-kappaB (NF-kappaB), which were blocked by the NF-kappaB inhibitors BAY 11-7082 and pyrrolidinedithiocarbamate ammonium. pyrrolidine dithiocarbamic acid 202-237 tumor necrosis factor Homo sapiens 0-9 23947625-7 2013 Pyrrolidine dithiocarbamate inhibited NF-kappaB activation, resulting in the down-regulation of nuclear NF-kappaB protein, which led to the down-regulation of the mRNA and protein levels of TNF-alpha and IL-6. pyrrolidine dithiocarbamic acid 0-27 tumor necrosis factor Homo sapiens 190-199 25893721-4 2015 The parallel treatment with pyrrolidine dithiocarbamate (PDTC) reversed the suppression of PTPIP51 protein expression induced by TNFalpha. pyrrolidine dithiocarbamic acid 28-55 tumor necrosis factor Homo sapiens 129-137 25893721-4 2015 The parallel treatment with pyrrolidine dithiocarbamate (PDTC) reversed the suppression of PTPIP51 protein expression induced by TNFalpha. pyrrolidine dithiocarbamic acid 57-61 tumor necrosis factor Homo sapiens 129-137 25637478-11 2015 In vitro treatment of endometrial cells with tumor necrosis factor-alpha caused a significant increase of NF-kB activation and Pak4 expression, which was obviously decreased by the NF-kB inhibitor pyrrolidinedithiocarbamate. pyrrolidine dithiocarbamic acid 197-223 tumor necrosis factor Homo sapiens 45-72 24587316-8 2014 The survival-prolonging effect of TNF-alpha was reversed by inhibitors of NF-kappaB pyrrolidinedithiocarbamate and gliotoxin and by an inhibitor of IkappaB kinase, BMS-345541. pyrrolidine dithiocarbamic acid 84-110 tumor necrosis factor Homo sapiens 34-43 27980322-10 2016 Knockdown of NF-kappaBp65 or NF-kappaBp65 inhibition by pyrrolidine dithiocarbamate (PDTC) enhanced AQP2 expression in IMCD cells exposed to TNF-alpha. pyrrolidine dithiocarbamic acid 56-83 tumor necrosis factor Homo sapiens 141-150 27980322-10 2016 Knockdown of NF-kappaBp65 or NF-kappaBp65 inhibition by pyrrolidine dithiocarbamate (PDTC) enhanced AQP2 expression in IMCD cells exposed to TNF-alpha. pyrrolidine dithiocarbamic acid 85-89 tumor necrosis factor Homo sapiens 141-150 26799794-7 2016 Moreover, the p38 MAPK inhibitor SD203580 and the nuclear factor (NF)-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) achieved similar repressive effects as resveratrol on TNF-alpha-induced ROS generation and CD40 expression. pyrrolidine dithiocarbamic acid 87-114 tumor necrosis factor Homo sapiens 176-185 26799794-7 2016 Moreover, the p38 MAPK inhibitor SD203580 and the nuclear factor (NF)-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) achieved similar repressive effects as resveratrol on TNF-alpha-induced ROS generation and CD40 expression. pyrrolidine dithiocarbamic acid 116-120 tumor necrosis factor Homo sapiens 176-185 25820389-7 2015 Meanwhile, the results showed that pyrrolidine dithiocarbamate (PDTC) (a specific inhibitor of the NF-kappaB signaling pathway) inhibited NLRC5 expression and NLRC5 silencing could increase the expression levels of p65 in cell nucleus accompanied with upregulated phosphorylation of Smad3 protein levels in response to TNF-alpha. pyrrolidine dithiocarbamic acid 35-62 tumor necrosis factor Homo sapiens 319-328 25820389-7 2015 Meanwhile, the results showed that pyrrolidine dithiocarbamate (PDTC) (a specific inhibitor of the NF-kappaB signaling pathway) inhibited NLRC5 expression and NLRC5 silencing could increase the expression levels of p65 in cell nucleus accompanied with upregulated phosphorylation of Smad3 protein levels in response to TNF-alpha. pyrrolidine dithiocarbamic acid 64-68 tumor necrosis factor Homo sapiens 319-328 25448063-4 2015 In this study, HepG2 cells were used to investigate the role of HSD17B4 in the proliferation of liver cancer cells treated with the NF-kappaB activator, tumor necrosis factor-alpha (TNF-alpha), with the inhibitor of NF-kappaB activation, pyrrolidinedithiocarbamate (PDTC), or with a related specific siRNA. pyrrolidine dithiocarbamic acid 238-264 tumor necrosis factor Homo sapiens 153-180 25448063-4 2015 In this study, HepG2 cells were used to investigate the role of HSD17B4 in the proliferation of liver cancer cells treated with the NF-kappaB activator, tumor necrosis factor-alpha (TNF-alpha), with the inhibitor of NF-kappaB activation, pyrrolidinedithiocarbamate (PDTC), or with a related specific siRNA. pyrrolidine dithiocarbamic acid 266-270 tumor necrosis factor Homo sapiens 153-180 25503960-5 2015 In addition, this effect was dependent upon NF-kappaB transcriptional activity, as blocking the NF-kappaB pathway with pyrrolidinedithiocarbamic acid ammonium salt suppressed TNF-alpha-induced upregulation of CXCR4 expression and reduced the migration towards the CXCR4 ligand, SDF-1alpha. pyrrolidine dithiocarbamic acid 119-163 tumor necrosis factor Homo sapiens 175-184 24613819-6 2014 Specific NF-kappaB inhibitors, pyrrolidine dithiocarbamate, MG132, and PS-1145, also attenuated TNF-alpha-mediated MMP-9 and VEGF expression as well as activity by suppressing their regulatory genes. pyrrolidine dithiocarbamic acid 31-58 tumor necrosis factor Homo sapiens 96-105 23567262-4 2013 Stimulation of podocytes with the cytokines TNF-alpha and IL-1beta up-regulated UCH-L1 expression rapidly at the mRNA and protein levels and the NF-kappaB-specific inhibitor pyrrolidine dithiocarbamate resulted in down-regulation. pyrrolidine dithiocarbamic acid 174-201 tumor necrosis factor Homo sapiens 44-53 21483233-8 2012 Inhibition of NF-kappaB activation by pyrrolidine dithiocarbamate impairs TNF-alpha-induced PTP-1B upregulation. pyrrolidine dithiocarbamic acid 38-65 tumor necrosis factor Homo sapiens 74-83 22288713-7 2012 Both the NF-kappaB inhibitor, PDTC (pyrrolidine dithiocarbamate) and TLR4 knockdown could block LPS induction of NF-kappaB, STIM, TNFalpha (tumour necrosis factor alpha) and IL-6 (interleukin 6). pyrrolidine dithiocarbamic acid 36-63 tumor necrosis factor Homo sapiens 130-138 23255946-10 2013 Using a specific NF-kappaB inhibitor, pyrrolidine dithiocarbamate, it was confirmed that TNF-alpha-induced MMP-9 gene expression is primarily regulated by NF-kappaB activation. pyrrolidine dithiocarbamic acid 38-65 tumor necrosis factor Homo sapiens 89-98 22613992-13 2012 Tryptase also activated NF-kappa B within 30 min, and ammonium pyrrolidinedithiocarbamate, an inhibitor of NF- kappa B, reduced tryptase-induced TNF-alpha and IL-6 release. pyrrolidine dithiocarbamic acid 54-89 tumor necrosis factor Homo sapiens 145-154 18446055-8 2008 Finally, pretreatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB, reduced TNF-alpha-induced ICAM-1 expression and both DPI and RacN17 significantly diminished NF-kappaB activation in response to TNF-alpha. pyrrolidine dithiocarbamic acid 27-54 tumor necrosis factor Homo sapiens 98-107 23221158-6 2012 The expression of uPA mRNA and PA secretion stimulated by TNF-alpha were reduced by the tyrosine kinase inhibitors herbimycin A and genistein, and by the NFkappaB inhibitor pyrrolidine dithiocarbamate, but were augmented by the tyrosine phosphatase inhibitor sodium orthovanadate. pyrrolidine dithiocarbamic acid 173-200 tumor necrosis factor Homo sapiens 58-67 18632801-7 2008 The NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), prevented these increases and significantly attenuated the TNF-alpha-induced cytotoxicity. pyrrolidine dithiocarbamic acid 25-52 tumor necrosis factor Homo sapiens 120-129 18632801-7 2008 The NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), prevented these increases and significantly attenuated the TNF-alpha-induced cytotoxicity. pyrrolidine dithiocarbamic acid 54-58 tumor necrosis factor Homo sapiens 120-129 19407978-6 2009 Furthermore, the inhibition of TNF-alpha-induced monocyte adhesion was also mimicked by the specific NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC). pyrrolidine dithiocarbamic acid 122-149 tumor necrosis factor Homo sapiens 31-40 19407978-6 2009 Furthermore, the inhibition of TNF-alpha-induced monocyte adhesion was also mimicked by the specific NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC). pyrrolidine dithiocarbamic acid 151-155 tumor necrosis factor Homo sapiens 31-40 18446055-8 2008 Finally, pretreatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB, reduced TNF-alpha-induced ICAM-1 expression and both DPI and RacN17 significantly diminished NF-kappaB activation in response to TNF-alpha. pyrrolidine dithiocarbamic acid 27-54 tumor necrosis factor Homo sapiens 219-228 18446055-8 2008 Finally, pretreatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB, reduced TNF-alpha-induced ICAM-1 expression and both DPI and RacN17 significantly diminished NF-kappaB activation in response to TNF-alpha. pyrrolidine dithiocarbamic acid 56-60 tumor necrosis factor Homo sapiens 98-107 18446055-8 2008 Finally, pretreatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB, reduced TNF-alpha-induced ICAM-1 expression and both DPI and RacN17 significantly diminished NF-kappaB activation in response to TNF-alpha. pyrrolidine dithiocarbamic acid 56-60 tumor necrosis factor Homo sapiens 219-228 17898021-12 2008 Furthermore, the increased synthesis of IL-6 and TNF-alpha by anionic pIgA in HMC was significantly diminished (P<0.01) in the presence of NF-kappaB inhibitor pyrrolidine dithiocarbamate and NF-kappaB blocking permeable peptides SN50 (P<0.01). pyrrolidine dithiocarbamic acid 162-189 tumor necrosis factor Homo sapiens 49-58 17765224-7 2007 ROS scavengers, pyrrolidinedithiocarbamate (PDTC) and N-acetyl-cysteine (NAC), reduced the levels of ROS induced by TNF-alpha, IL-1 beta and IFN-gamma (P<0.05). pyrrolidine dithiocarbamic acid 16-42 tumor necrosis factor Homo sapiens 116-125 17765224-7 2007 ROS scavengers, pyrrolidinedithiocarbamate (PDTC) and N-acetyl-cysteine (NAC), reduced the levels of ROS induced by TNF-alpha, IL-1 beta and IFN-gamma (P<0.05). pyrrolidine dithiocarbamic acid 44-48 tumor necrosis factor Homo sapiens 116-125 17253597-6 2007 Co-incubation of MPM cells with TNF-alpha and pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, prevented TNF-mediated up-regulation of IAP gene expression levels. pyrrolidine dithiocarbamic acid 75-79 tumor necrosis factor Homo sapiens 32-41 17266944-1 2007 OBJECTIVES: The aim of this study was to investigate the effect of the antioxidants pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC) on the ionizing radiation (IR)- and tumor necrosis factor-alpha (TNF-alpha) induced tissue factor (TF) expression and its release from human umbilical vein endothelial cells (HUVECs). pyrrolidine dithiocarbamic acid 84-111 tumor necrosis factor Homo sapiens 182-209 17266944-1 2007 OBJECTIVES: The aim of this study was to investigate the effect of the antioxidants pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC) on the ionizing radiation (IR)- and tumor necrosis factor-alpha (TNF-alpha) induced tissue factor (TF) expression and its release from human umbilical vein endothelial cells (HUVECs). pyrrolidine dithiocarbamic acid 84-111 tumor necrosis factor Homo sapiens 211-220 17266944-1 2007 OBJECTIVES: The aim of this study was to investigate the effect of the antioxidants pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC) on the ionizing radiation (IR)- and tumor necrosis factor-alpha (TNF-alpha) induced tissue factor (TF) expression and its release from human umbilical vein endothelial cells (HUVECs). pyrrolidine dithiocarbamic acid 113-117 tumor necrosis factor Homo sapiens 182-209 17266944-1 2007 OBJECTIVES: The aim of this study was to investigate the effect of the antioxidants pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC) on the ionizing radiation (IR)- and tumor necrosis factor-alpha (TNF-alpha) induced tissue factor (TF) expression and its release from human umbilical vein endothelial cells (HUVECs). pyrrolidine dithiocarbamic acid 113-117 tumor necrosis factor Homo sapiens 211-220 17314215-8 2007 The production of IL-1beta, IL-6 and IL-8 induced by TNF-alpha was decreased by pyrrolidine dithiocarbamate (PDTC), a chemical inhibitor of NF-kappaB. pyrrolidine dithiocarbamic acid 80-107 tumor necrosis factor Homo sapiens 53-62 17314215-8 2007 The production of IL-1beta, IL-6 and IL-8 induced by TNF-alpha was decreased by pyrrolidine dithiocarbamate (PDTC), a chemical inhibitor of NF-kappaB. pyrrolidine dithiocarbamic acid 109-113 tumor necrosis factor Homo sapiens 53-62 17253597-6 2007 Co-incubation of MPM cells with TNF-alpha and pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, prevented TNF-mediated up-regulation of IAP gene expression levels. pyrrolidine dithiocarbamic acid 75-79 tumor necrosis factor Homo sapiens 32-35 16973825-4 2006 We found that TNF-alpha significantly increased adhesiveness of the monocytic THP-1 cells to HCAECs, an effect that could be inhibited by pretreatment with resveratrol and the NF-kappaB inhibitor pyrrolidine dithiocarbamate. pyrrolidine dithiocarbamic acid 196-223 tumor necrosis factor Homo sapiens 14-23 17334236-6 2007 TNF-alpha increased PTEN expression at HL-60 cells in a time- and dose-dependent manner, but the response was abolished by disruption of NF-kappaB with p65 antisense phosphorothioate oligonucleotide or pyrrolidine dithiocarbamate. pyrrolidine dithiocarbamic acid 202-229 tumor necrosis factor Homo sapiens 0-9 16973825-7 2006 Using a reporter gene assay, we found that, in HCAECs, TNF-alpha significantly increased NF-kappaB activity, which could be inhibited by resveratrol (>50% inhibition at 10(-6) mol/l) and pyrrolidine dithiocarbamate. pyrrolidine dithiocarbamic acid 190-217 tumor necrosis factor Homo sapiens 55-64 16520234-8 2006 The long-term exposure to oxidized LDL also significantly enhanced tumor necrosis factor-alpha (TNF-alpha)-stimulated ROS production and endothelial adhesiveness of MMCs, which could be completely abolished by the short-term existence of pyrrolidine dithiocarbamate (PDTC), an antioxidant and NF-kappaB blocker and by long-term coincubation with N-acetylcysteine, a nonspecific antioxidant. pyrrolidine dithiocarbamic acid 238-265 tumor necrosis factor Homo sapiens 67-94 16520234-8 2006 The long-term exposure to oxidized LDL also significantly enhanced tumor necrosis factor-alpha (TNF-alpha)-stimulated ROS production and endothelial adhesiveness of MMCs, which could be completely abolished by the short-term existence of pyrrolidine dithiocarbamate (PDTC), an antioxidant and NF-kappaB blocker and by long-term coincubation with N-acetylcysteine, a nonspecific antioxidant. pyrrolidine dithiocarbamic acid 238-265 tumor necrosis factor Homo sapiens 96-105 16520234-8 2006 The long-term exposure to oxidized LDL also significantly enhanced tumor necrosis factor-alpha (TNF-alpha)-stimulated ROS production and endothelial adhesiveness of MMCs, which could be completely abolished by the short-term existence of pyrrolidine dithiocarbamate (PDTC), an antioxidant and NF-kappaB blocker and by long-term coincubation with N-acetylcysteine, a nonspecific antioxidant. pyrrolidine dithiocarbamic acid 267-271 tumor necrosis factor Homo sapiens 67-94 16520234-8 2006 The long-term exposure to oxidized LDL also significantly enhanced tumor necrosis factor-alpha (TNF-alpha)-stimulated ROS production and endothelial adhesiveness of MMCs, which could be completely abolished by the short-term existence of pyrrolidine dithiocarbamate (PDTC), an antioxidant and NF-kappaB blocker and by long-term coincubation with N-acetylcysteine, a nonspecific antioxidant. pyrrolidine dithiocarbamic acid 267-271 tumor necrosis factor Homo sapiens 96-105 12573143-9 2002 The antioxidant, pyrrolidine dithiocarbamate, reduced TNF-induced, but not the constitutive, NF-kappaB activation. pyrrolidine dithiocarbamic acid 17-44 tumor necrosis factor Homo sapiens 54-57 17357478-5 2006 NF-kappaB activity induced by TNF-alpha was significantly increased in AM from patients with COPD, and pyrrolidine dithiocarbamate (PDTC) and N-acetyl-L-cysteine (NAC) significantly inhibited the activation of NF-kappaB induced by TNF-alpha (P<0.05). pyrrolidine dithiocarbamic acid 103-130 tumor necrosis factor Homo sapiens 231-240 17357478-5 2006 NF-kappaB activity induced by TNF-alpha was significantly increased in AM from patients with COPD, and pyrrolidine dithiocarbamate (PDTC) and N-acetyl-L-cysteine (NAC) significantly inhibited the activation of NF-kappaB induced by TNF-alpha (P<0.05). pyrrolidine dithiocarbamic acid 132-136 tumor necrosis factor Homo sapiens 30-39 17357478-5 2006 NF-kappaB activity induced by TNF-alpha was significantly increased in AM from patients with COPD, and pyrrolidine dithiocarbamate (PDTC) and N-acetyl-L-cysteine (NAC) significantly inhibited the activation of NF-kappaB induced by TNF-alpha (P<0.05). pyrrolidine dithiocarbamic acid 132-136 tumor necrosis factor Homo sapiens 231-240 15851600-3 2005 METHODS AND RESULTS: The proinflammatory cytokine tumor necrosis factor (TNF)-alpha induced NF-kappaBeta activation and elicited significant increases in BMP-2 mRNA and protein in primary coronary arterial endothelial cells and human umbilical vein endothelial cells that were prevented by NF-kappaBeta inhibitors (pyrrolidine dithiocarbamate and SN-50), silencing of p65 (siRNA), or catalase. pyrrolidine dithiocarbamic acid 315-342 tumor necrosis factor Homo sapiens 50-83 15897117-6 2005 Pretreatment of the cells with pyrrolidine dithiocarbamate scavenged most of ROS and almost completely blocked TNF-alpha secretion induced by AOPP-BSA. pyrrolidine dithiocarbamic acid 31-58 tumor necrosis factor Homo sapiens 111-120 15532722-8 2004 Both the fever and the increased levels of IL-1beta, IL-6, and TNF-alpha in supernatant fluids obtained from the SEA-stimulated PBMC were decreased by incubating SEA-PBMC with either PDTC, Pyri, NAC, or Cur. pyrrolidine dithiocarbamic acid 183-187 tumor necrosis factor Homo sapiens 63-72 16457791-8 2006 On the other hand, the other NFkappaB inhibitor ammonium pyrrolidine dithiocarbamate (APDC) neither prevented the activation of p38MAPK and JNK nor inhibited TNFalpha induction in LPS-stimulated microglia, although it was confirmed to serve as an NFkappaB inhibitor. pyrrolidine dithiocarbamic acid 48-84 tumor necrosis factor Homo sapiens 158-166 16457791-8 2006 On the other hand, the other NFkappaB inhibitor ammonium pyrrolidine dithiocarbamate (APDC) neither prevented the activation of p38MAPK and JNK nor inhibited TNFalpha induction in LPS-stimulated microglia, although it was confirmed to serve as an NFkappaB inhibitor. pyrrolidine dithiocarbamic acid 86-90 tumor necrosis factor Homo sapiens 158-166 16109311-4 2005 Interestingly, both IL-1beta and TNF-alpha markedly inhibited the expression of MOG, CNPase, and PLP but not MBP, the effect that was blocked by antioxidants such as N-acetylcysteine (NAC) and pyrrolidine dithiocarbamate (PDTC). pyrrolidine dithiocarbamic acid 193-220 tumor necrosis factor Homo sapiens 33-42 16109311-4 2005 Interestingly, both IL-1beta and TNF-alpha markedly inhibited the expression of MOG, CNPase, and PLP but not MBP, the effect that was blocked by antioxidants such as N-acetylcysteine (NAC) and pyrrolidine dithiocarbamate (PDTC). pyrrolidine dithiocarbamic acid 222-226 tumor necrosis factor Homo sapiens 33-42 15696609-3 2004 Enhanced nuclear factor-kappa B (NF-kappaB) activation was also induced in Mo-DCs-Tum within 6 h. The NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), suppressed both IL-12 and TNF-alpha secretions from Mo-DCs-Tum. pyrrolidine dithiocarbamic acid 123-150 tumor necrosis factor Homo sapiens 185-194 15696609-3 2004 Enhanced nuclear factor-kappa B (NF-kappaB) activation was also induced in Mo-DCs-Tum within 6 h. The NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), suppressed both IL-12 and TNF-alpha secretions from Mo-DCs-Tum. pyrrolidine dithiocarbamic acid 152-156 tumor necrosis factor Homo sapiens 185-194 14751545-7 2004 TNF-alpha-induced COX-2 expression and PGE2 synthesis was also inhibited by NF-kappaB inhibitor pyrrolidinedithiocarbamate (PDTC). pyrrolidine dithiocarbamic acid 96-122 tumor necrosis factor Homo sapiens 0-9 14751545-7 2004 TNF-alpha-induced COX-2 expression and PGE2 synthesis was also inhibited by NF-kappaB inhibitor pyrrolidinedithiocarbamate (PDTC). pyrrolidine dithiocarbamic acid 124-128 tumor necrosis factor Homo sapiens 0-9 14641910-5 2003 Part of the TNF-induced gene expression could be inhibited by pharmacological inhibition of NF-kappaB with pyrrolidine-dithiocarbamate (PDTC). pyrrolidine dithiocarbamic acid 107-134 tumor necrosis factor Homo sapiens 12-15 14641910-5 2003 Part of the TNF-induced gene expression could be inhibited by pharmacological inhibition of NF-kappaB with pyrrolidine-dithiocarbamate (PDTC). pyrrolidine dithiocarbamic acid 136-140 tumor necrosis factor Homo sapiens 12-15 14572618-1 2003 We demonstrate that two different cell-permeable antioxidants, pyrrolidine dithiocarbamate (PDTC) and dimethylthiourea (DMTU), inhibit TNFalpha-induced ICAM-1 surface and gene expression in primary cultures of differentiated normal human bronchial epithelial (NHBE) cells. pyrrolidine dithiocarbamic acid 63-90 tumor necrosis factor Homo sapiens 135-143 14572618-1 2003 We demonstrate that two different cell-permeable antioxidants, pyrrolidine dithiocarbamate (PDTC) and dimethylthiourea (DMTU), inhibit TNFalpha-induced ICAM-1 surface and gene expression in primary cultures of differentiated normal human bronchial epithelial (NHBE) cells. pyrrolidine dithiocarbamic acid 92-96 tumor necrosis factor Homo sapiens 135-143 11264769-13 2001 An inhibition of NF-kappaB by pyrrolidine dithiocarbamate attenuated IL-1beta and TNF-alpha synthesis. pyrrolidine dithiocarbamic acid 30-57 tumor necrosis factor Homo sapiens 82-91 12237255-9 2002 4 Antioxidants (pyrrolidine dithiocarbamate and N-acetyl-L-cysteine) inhibited GPI-80 release by TNF-alpha stimulation, but superoxide dismutase did not. pyrrolidine dithiocarbamic acid 16-43 tumor necrosis factor Homo sapiens 97-106 12349897-10 2002 PDTC and herbimycin A attenuated TNF-alpha-stimulated PGE2 release. pyrrolidine dithiocarbamic acid 0-4 tumor necrosis factor Homo sapiens 33-42 11704541-4 2001 Increased expression of MMP-9 and NF-kappa B activation induced by TNF-alpha were inhibited by pyrrolidine dithiocarbamate and N-acetyl-L-cysteine but were not inhibited by curcumin. pyrrolidine dithiocarbamic acid 95-122 tumor necrosis factor Homo sapiens 67-76 11699074-3 2001 In the present studies, we evaluated the effect of the antioxidant, pyrrolidine dithiocarbamate (PDTC), on murine and human myeloid cell tumor necrosis factor alpha (TNF alpha) gene and protein expression. pyrrolidine dithiocarbamic acid 68-95 tumor necrosis factor Homo sapiens 137-164 11699074-3 2001 In the present studies, we evaluated the effect of the antioxidant, pyrrolidine dithiocarbamate (PDTC), on murine and human myeloid cell tumor necrosis factor alpha (TNF alpha) gene and protein expression. pyrrolidine dithiocarbamic acid 68-95 tumor necrosis factor Homo sapiens 166-175 11699074-3 2001 In the present studies, we evaluated the effect of the antioxidant, pyrrolidine dithiocarbamate (PDTC), on murine and human myeloid cell tumor necrosis factor alpha (TNF alpha) gene and protein expression. pyrrolidine dithiocarbamic acid 97-101 tumor necrosis factor Homo sapiens 137-164 11699074-3 2001 In the present studies, we evaluated the effect of the antioxidant, pyrrolidine dithiocarbamate (PDTC), on murine and human myeloid cell tumor necrosis factor alpha (TNF alpha) gene and protein expression. pyrrolidine dithiocarbamic acid 97-101 tumor necrosis factor Homo sapiens 166-175 11834481-5 2002 Furthermore, inhibitors of NF-kappaB activation, such as lactacystin, MG132, and pyrrolidine dithiocarbamate, were found to completely block the production of TNF-alpha in response to LPS stimulation, indicating a requirement of NF-kappaB for TNF-alpha expression. pyrrolidine dithiocarbamic acid 81-108 tumor necrosis factor Homo sapiens 159-168 11834481-5 2002 Furthermore, inhibitors of NF-kappaB activation, such as lactacystin, MG132, and pyrrolidine dithiocarbamate, were found to completely block the production of TNF-alpha in response to LPS stimulation, indicating a requirement of NF-kappaB for TNF-alpha expression. pyrrolidine dithiocarbamic acid 81-108 tumor necrosis factor Homo sapiens 243-252 11928721-7 2002 Pretreatment with antioxidants, pyrrolidine dithiocarbamate and alpha-lipoic acid, both of which are known to be suppressors of NF-kappaB activation, effectively attenuated basal and TNF-alpha-induced ET-1 release. pyrrolidine dithiocarbamic acid 32-59 tumor necrosis factor Homo sapiens 183-192 11358991-6 2001 Pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB activation, attenuated approximately 70% of IL-8 release evoked by IL-1beta, TNF-alpha, or ONOO(-). pyrrolidine dithiocarbamic acid 0-27 tumor necrosis factor Homo sapiens 132-141 11068016-5 2000 Caspase-3 activation by TNF-alpha was significantly enhanced by pretreatment with both cycloheximide and pyrrolidine dithiocarbamate. pyrrolidine dithiocarbamic acid 105-132 tumor necrosis factor Homo sapiens 24-33 11068016-7 2000 Furthermore, TNF-alpha increased NF-kappaB DNA binding, which was abolished by pretreatment with pyrrolidine dithiocarbamate. pyrrolidine dithiocarbamic acid 97-124 tumor necrosis factor Homo sapiens 13-22 10652367-4 2000 A role for the transcription factor NFkappaB in Sox9 down-regulation was suggested by the ability of pyrrolidine dithiocarbamate, an inhibitor of the NFkappaB pathway, to block the effects of IL-1 and TNF-alpha. pyrrolidine dithiocarbamic acid 101-128 tumor necrosis factor Homo sapiens 201-210 11006087-0 2000 Pyrrolidine dithiocarbamate inhibits TNF-alpha-dependent activation of NF-kappaB by increasing intracellular copper level in human aortic smooth muscle cells. pyrrolidine dithiocarbamic acid 0-27 tumor necrosis factor Homo sapiens 37-46 10803841-4 2000 Furthermore, the stimulation of pIgR mRNA by TNF-alpha was decreased by pyrrolidinedithiocarbamate and L-1-4"-tosylamino-phenylethyl-chloromethyl ketone, which are known nuclear factor (NF)-kappaB inhibitors. pyrrolidine dithiocarbamic acid 72-98 tumor necrosis factor Homo sapiens 45-54 11079460-8 2000 Additionally, the ethanol-mediated potentiation of TNF-alpha-inducible NFkappaB activation was abrogated by the known antioxidant pyrrolidinedithiocarbamate, suggesting an important mechanistic role for reactive oxygen species in this process. pyrrolidine dithiocarbamic acid 130-156 tumor necrosis factor Homo sapiens 51-60 10759767-5 2000 We also found that a potent inhibitor of NF-kappaB, pyrrolidine dithiocarbamate (PDTC) in a dose-dependent manner impaired TNF-alpha-induced cytotoxicity, indicating a role of NF-kappaB activation in cytokine-induced endothelial injury. pyrrolidine dithiocarbamic acid 52-79 tumor necrosis factor Homo sapiens 123-132 10759767-5 2000 We also found that a potent inhibitor of NF-kappaB, pyrrolidine dithiocarbamate (PDTC) in a dose-dependent manner impaired TNF-alpha-induced cytotoxicity, indicating a role of NF-kappaB activation in cytokine-induced endothelial injury. pyrrolidine dithiocarbamic acid 81-85 tumor necrosis factor Homo sapiens 123-132 10706556-9 2000 Inhibition of NF-kappaB activation by pyrrolidine dithiocarbamate sensitized them to TNF-alpha-induced apoptosis. pyrrolidine dithiocarbamic acid 38-65 tumor necrosis factor Homo sapiens 85-94 10430178-9 1999 The antioxidant pyrrolidine dithiocarbamate (PDTC) similarly inhibited VCAM-1 upregulation in HASMCs incubated with IL-4 and in HUVECs incubated with TNF-alpha (IC50s of 25 and 40 microM, respectively). pyrrolidine dithiocarbamic acid 16-43 tumor necrosis factor Homo sapiens 150-159 10619820-10 2000 Inhibition of NF-kappaB by pyrrolidine dithiocarbamate attenuated IL-1beta and TNF-alpha synthesis. pyrrolidine dithiocarbamic acid 27-54 tumor necrosis factor Homo sapiens 79-88 10430178-9 1999 The antioxidant pyrrolidine dithiocarbamate (PDTC) similarly inhibited VCAM-1 upregulation in HASMCs incubated with IL-4 and in HUVECs incubated with TNF-alpha (IC50s of 25 and 40 microM, respectively). pyrrolidine dithiocarbamic acid 45-49 tumor necrosis factor Homo sapiens 150-159 10233023-1 1999 In L6 myotubes, glucose uptake stimulated by interferon (IFN)-gamma or lipopolysaccharides (LPS) and a combination of LPS, IFN-gamma, and tumor necrosis factor (TNF)-alpha was inhibited by the antioxidant pyrrolidinedithiocarbamate and potentiated in reduced glutathione (GSH)-deficient cells. pyrrolidine dithiocarbamic acid 205-231 tumor necrosis factor Homo sapiens 138-171 10416602-4 1999 Blocking TNF-alpha expression via treatment with pyrrolidinedithiocarbamate or blocking TNF-alpha activity with neutralizing antibodies abrogated heat-provoked apoptosis. pyrrolidine dithiocarbamic acid 49-75 tumor necrosis factor Homo sapiens 9-18 9824162-6 1998 This hypothesis is supported by the following observations: (1) TNF and rotenone induced MPT and cytochrome c release; (2) TNF-induced complex I inhibition was observed prior to cytochrome c release and MPT induction; (3) MPT induction was inhibited by a caspase 3 inhibitor, z-DEVD-CH2F, and an antioxidant pyrrolidine dithiocarbamate (PDTC), whereas cytochrome c release was only inhibited by PDTC. pyrrolidine dithiocarbamic acid 308-335 tumor necrosis factor Homo sapiens 123-126 9887050-5 1999 Pyrrolidinedithiocarbamate and the proteasome inhibitor MG-132 blocked TNF- and LPS-stimulated U-937 cell adhesion to HUVECs. pyrrolidine dithiocarbamic acid 0-26 tumor necrosis factor Homo sapiens 71-74 9887050-7 1999 TNF increased VCAM-1 protein and mRNA in HUVECs that was blocked by pyrrolidinedithiocarbamate. pyrrolidine dithiocarbamic acid 68-94 tumor necrosis factor Homo sapiens 0-3 9890996-7 1999 Furthermore, VCAM-1 mRNA induction was inhibited in TNF-alpha-stimulated SMCs, but not in differentiating SMCs, by pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB protein activation. pyrrolidine dithiocarbamic acid 115-142 tumor necrosis factor Homo sapiens 52-61 9833740-8 1998 Pyrrolidine dithiocarbamate, a potent transcriptional inhibitor of the viral LTR, abrogated the cytokine responses in both U1 and ACH-2 cells, suggesting a common TNF-alpha-mediated transcriptional mechanism in these cell types despite their different modes of provirus latency. pyrrolidine dithiocarbamic acid 0-27 tumor necrosis factor Homo sapiens 163-172 9824162-6 1998 This hypothesis is supported by the following observations: (1) TNF and rotenone induced MPT and cytochrome c release; (2) TNF-induced complex I inhibition was observed prior to cytochrome c release and MPT induction; (3) MPT induction was inhibited by a caspase 3 inhibitor, z-DEVD-CH2F, and an antioxidant pyrrolidine dithiocarbamate (PDTC), whereas cytochrome c release was only inhibited by PDTC. pyrrolidine dithiocarbamic acid 337-341 tumor necrosis factor Homo sapiens 123-126 9756946-5 1998 Tumor necrosis factor alpha inhibits CYP1A1 expression, and this inhibition is prevented by the antioxidant pyrrolidine dithiocarbamate. pyrrolidine dithiocarbamic acid 108-135 tumor necrosis factor Homo sapiens 0-27 9593751-11 1998 The antioxidant pyrrolidine dithiocarbamate also suppressed constitutive NF-kappaB activation and it reversed the cell"s sensitivity to TNF-induced cytotoxicity and activation of caspase-3. pyrrolidine dithiocarbamic acid 16-43 tumor necrosis factor Homo sapiens 136-139 9728048-3 1998 Pretreatment with N-acetyl-L-cysteine (NAC) or pyrrolidine dithiocarbamate (PDTC) for 0.5 h inhibited TNF-alpha-induced generation of ROS as well as activation of NF-kappaB and E-selectin mRNA and the cell surface protein expression. pyrrolidine dithiocarbamic acid 47-74 tumor necrosis factor Homo sapiens 102-111 9728048-3 1998 Pretreatment with N-acetyl-L-cysteine (NAC) or pyrrolidine dithiocarbamate (PDTC) for 0.5 h inhibited TNF-alpha-induced generation of ROS as well as activation of NF-kappaB and E-selectin mRNA and the cell surface protein expression. pyrrolidine dithiocarbamic acid 76-80 tumor necrosis factor Homo sapiens 102-111 9268159-3 1997 N-Acetylcysteine (NAC), pyrrolidinedithiocarbamate (PDTC), and Trimidox (TD) at various concentrations inhibited TNF-alpha-induced NF-kappaB binding in Jurkat cells. pyrrolidine dithiocarbamic acid 24-50 tumor necrosis factor Homo sapiens 113-122 9325328-7 1997 However, we found that tumor necrosis factor- but not interleukin-1-driven NF-kappaB activation and IkappaBalpha degradation were sensitive to pyrrolidine dithiocarbamate in transformed cells, while neither pathway was inhibited in primary cells. pyrrolidine dithiocarbamic acid 143-170 tumor necrosis factor Homo sapiens 23-44 9268159-3 1997 N-Acetylcysteine (NAC), pyrrolidinedithiocarbamate (PDTC), and Trimidox (TD) at various concentrations inhibited TNF-alpha-induced NF-kappaB binding in Jurkat cells. pyrrolidine dithiocarbamic acid 52-56 tumor necrosis factor Homo sapiens 113-122 7545393-5 1995 We show that pyrrolidine dithiocarbamate strongly reduces the TNF alpha-mediated induction of E-selectin, VCAM-1, ICAM-1, PAI-1, tissue factor, IL-8 and I kappa B-alpha. pyrrolidine dithiocarbamic acid 13-40 tumor necrosis factor Homo sapiens 62-71 9048649-10 1997 Induction of E-selectin mRNA by lipopolysaccharide or TNF-alpha in cycloheximide-treated HASMCs was inhibited by the antioxidant pyrrolidinedithiocarbamate and the serine protease inhibitor N alpha-L-tosyl-L-phenylalanine chloromethyl ketone, suggesting that a nuclear factor-kappa B-like mechanism may play an important role in E-selectin gene expression in HASMCs. pyrrolidine dithiocarbamic acid 129-155 tumor necrosis factor Homo sapiens 54-63 8766564-9 1996 TNF-alpha, but not cAMP-induced IL-10 gene expression was inhibited by pyrrolidine dithiocarbamate, suggesting the involvement of reactive oxygen species. pyrrolidine dithiocarbamic acid 71-98 tumor necrosis factor Homo sapiens 0-9 34463587-11 2021 Furthermore, PDTC decreased IL-1beta-induced chondrocyte apoptosis with the upregulated COL1A1, COL2A1, COL10A1 and ACAN, as well as the down-regulated MMP1, MMP13, COX2, iNOS, IL-6, TNF-alpha, NO and PGE2, which was reversed by A20 siRNA. pyrrolidine dithiocarbamic acid 13-17 tumor necrosis factor Homo sapiens 183-192 7957773-3 1994 The intracellular oxidation state was increased 60 min after the addition of TNF alpha, and this increase was abolished by a radical scavenger, N-acetylcysteine (NAC), which is also a precursor of glutathione, and by pyrrolidine dithiocarbamate (PDTC). pyrrolidine dithiocarbamic acid 217-244 tumor necrosis factor Homo sapiens 77-86 7957773-3 1994 The intracellular oxidation state was increased 60 min after the addition of TNF alpha, and this increase was abolished by a radical scavenger, N-acetylcysteine (NAC), which is also a precursor of glutathione, and by pyrrolidine dithiocarbamate (PDTC). pyrrolidine dithiocarbamic acid 246-250 tumor necrosis factor Homo sapiens 77-86 8258705-0 1993 Pyrrolidine dithiocarbamate inhibits NF-kappa B mobilization and TNF production in human monocytes. pyrrolidine dithiocarbamic acid 0-27 tumor necrosis factor Homo sapiens 65-68 33561598-7 2021 Ammonium pyrrolidinedithiocarbamate (PDTC), a specific nuclear factor kappa-B (NF-kappaB) activity blocker, significantly inhibited autophagy induced by TNF-alpha. pyrrolidine dithiocarbamic acid 0-35 tumor necrosis factor Homo sapiens 153-162 34787893-8 2021 Overexpression of S100A10 had an effect similar to TNF-alpha,which was significantly counteracted by pyrrolidine dithiocarbamate, an NF-kappaB inhibitor, or verapamil, a calcium-channel blocker. pyrrolidine dithiocarbamic acid 101-128 tumor necrosis factor Homo sapiens 51-60 35485360-9 2021 After treatment with PDTC + TNF-alpha, the abundance of the protein for p-NF-kappaBp65 decreased and GLUT-4 increased compared with the TNF-alpha group; these values were close to those of the control group. pyrrolidine dithiocarbamic acid 21-25 tumor necrosis factor Homo sapiens 28-37 35624646-10 2022 The expression of protein intercellular cell adhesion molecule (ICAM-1) and human beta defensin-2 (HBD2) decreased when exposed to TNF-alpha and LPS, but recovered with the NF-kappaB inhibitor treatment- Pyrrolidinedithiocarbamic acid (PDTC), indicating the stability of the fabricated chip. pyrrolidine dithiocarbamic acid 236-240 tumor necrosis factor Homo sapiens 131-140 33561598-7 2021 Ammonium pyrrolidinedithiocarbamate (PDTC), a specific nuclear factor kappa-B (NF-kappaB) activity blocker, significantly inhibited autophagy induced by TNF-alpha. pyrrolidine dithiocarbamic acid 37-41 tumor necrosis factor Homo sapiens 153-162 33158173-11 2020 NF-kappaB pathway inhibition with ammonium pyrrolidinedithiocarbamate (PDTC) caused a significant decrease in CCL21 secretion, suggesting that TNF-alpha-induced CCL21 secretion in HLEC was through NF-kappaB pathway. pyrrolidine dithiocarbamic acid 34-69 tumor necrosis factor Homo sapiens 143-152 33158173-11 2020 NF-kappaB pathway inhibition with ammonium pyrrolidinedithiocarbamate (PDTC) caused a significant decrease in CCL21 secretion, suggesting that TNF-alpha-induced CCL21 secretion in HLEC was through NF-kappaB pathway. pyrrolidine dithiocarbamic acid 71-75 tumor necrosis factor Homo sapiens 143-152