PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15954894-13 2005 Pretreatment of the cells with NF-kappaB inhibitor pyrrolidine dithio-carbamate (PDTC) blocked the productions of IL-1beta, IL-6, and activation of NF-kappaB induced by TNF-alpha. pyrrolidine dithiocarbamic acid 51-79 interleukin 1 beta Rattus norvegicus 114-122 16580131-3 2006 LPS-inducible IL-1beta was significantly suppressed by pretreatment with the nuclear factor kappa B (NFkappaB) inhibitor ammonium pyrrolidine dithiocarbamate (APDC), but TNFalpha was not. pyrrolidine dithiocarbamic acid 121-157 interleukin 1 beta Rattus norvegicus 14-22 16580131-3 2006 LPS-inducible IL-1beta was significantly suppressed by pretreatment with the nuclear factor kappa B (NFkappaB) inhibitor ammonium pyrrolidine dithiocarbamate (APDC), but TNFalpha was not. pyrrolidine dithiocarbamic acid 159-163 interleukin 1 beta Rattus norvegicus 14-22 15954894-13 2005 Pretreatment of the cells with NF-kappaB inhibitor pyrrolidine dithio-carbamate (PDTC) blocked the productions of IL-1beta, IL-6, and activation of NF-kappaB induced by TNF-alpha. pyrrolidine dithiocarbamic acid 81-85 interleukin 1 beta Rattus norvegicus 114-122 12540607-10 2003 Blocking of NF-kappaB activation in cytokine-exposed primary beta-cells by an adenovirus overexpressing a nondegradable form of IkappaBalpha or by pyrrolidine dithiocarbamate decreased IL-1beta-induced MCP-1 mRNA expression. pyrrolidine dithiocarbamic acid 147-174 interleukin 1 beta Rattus norvegicus 185-193 12498315-12 2002 IL-1beta induced expression of intercellular adhesion molecule-1 and monocyte chemoattractant protein-1, both of which were abolished in the presence of pyrrolidine dithiocarbamate, a specific inhibitor of nuclear factor-kappaB activation. pyrrolidine dithiocarbamic acid 153-180 interleukin 1 beta Rattus norvegicus 0-8 11530235-10 2001 Furthermore, both pyrrolidine dithiocarbamate and rotenone also decreased interleukin 1beta-induced 8-isoprostaglandin F(2alpha) production. pyrrolidine dithiocarbamic acid 18-45 interleukin 1 beta Rattus norvegicus 74-91 11578593-9 2001 Application of pyrrolidine dithiocarbamate, an inhibitor of nuclear factor-kB (NF-kappaB), prior to LPS stimulation not only prevented up-regulation of NF-kappaB gene expression, but also completely blocked up-regulation of pro-inflammatory cytokine genes (TNF-alpha and interleukin-1beta) and two chemokine genes: CXC chemokine LIX and CC chemokine MIP-3 alpha. pyrrolidine dithiocarbamic acid 15-42 interleukin 1 beta Rattus norvegicus 271-288 11530235-6 2001 The oxidant scavenger pyrrolidine dithiocarbamate abolished interleukin 1beta-induced NOS-2 mRNA accumulation and decreased nitric oxide production in a concentration-dependent manner, thus indicating that this antioxidant decreased either the transcription of NOS-2 gene or the stability of NOS-2 mRNA. pyrrolidine dithiocarbamic acid 22-49 interleukin 1 beta Rattus norvegicus 60-77 8754764-7 1996 Pyrrolidine dithiocarbamate also reduced IL-1 beta-induced nitrite formation. pyrrolidine dithiocarbamic acid 0-27 interleukin 1 beta Rattus norvegicus 41-50 8941724-4 1996 Group II phospholipase A2 (sPLA2) is expressed in rat glomerular mesangial cells upon exposure to the inflammatory cytokine interleukin-1beta (IL-1beta) and this induction is attenuated by the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC). pyrrolidine dithiocarbamic acid 213-240 interleukin 1 beta Rattus norvegicus 124-141 8941724-4 1996 Group II phospholipase A2 (sPLA2) is expressed in rat glomerular mesangial cells upon exposure to the inflammatory cytokine interleukin-1beta (IL-1beta) and this induction is attenuated by the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC). pyrrolidine dithiocarbamic acid 213-240 interleukin 1 beta Rattus norvegicus 143-151 8941724-4 1996 Group II phospholipase A2 (sPLA2) is expressed in rat glomerular mesangial cells upon exposure to the inflammatory cytokine interleukin-1beta (IL-1beta) and this induction is attenuated by the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC). pyrrolidine dithiocarbamic acid 242-246 interleukin 1 beta Rattus norvegicus 124-141 8941724-4 1996 Group II phospholipase A2 (sPLA2) is expressed in rat glomerular mesangial cells upon exposure to the inflammatory cytokine interleukin-1beta (IL-1beta) and this induction is attenuated by the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC). pyrrolidine dithiocarbamic acid 242-246 interleukin 1 beta Rattus norvegicus 143-151 8760147-13 1996 IL-1 beta-mediated increases in steady-state iNOS mRNA were sensitive to pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappa B activation. pyrrolidine dithiocarbamic acid 73-100 interleukin 1 beta Rattus norvegicus 0-9 8672550-6 1996 Pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of NF-kappa B activation, inhibited the NTS-induced increase of glomerular NF-kappa B DNA-binding activity, followed by the inhibition of mRNA expression of IL-1 beta, MCP-1, ICAM-1 and iNOS, which are known to be regulated by NF-kappa B. PDTC also prevented urinary protein excretion which is a pathophysiological parameter for glomerulonephritis. pyrrolidine dithiocarbamic acid 0-27 interleukin 1 beta Rattus norvegicus 212-221 8672550-6 1996 Pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of NF-kappa B activation, inhibited the NTS-induced increase of glomerular NF-kappa B DNA-binding activity, followed by the inhibition of mRNA expression of IL-1 beta, MCP-1, ICAM-1 and iNOS, which are known to be regulated by NF-kappa B. PDTC also prevented urinary protein excretion which is a pathophysiological parameter for glomerulonephritis. pyrrolidine dithiocarbamic acid 29-33 interleukin 1 beta Rattus norvegicus 212-221 31837574-7 2020 Moreover, PDX inhibited the increase in phosphorylated NF-kappaB p65 and IkappaBalpha upon IL-1beta stimulation, and the negative effects of IL-1beta on chondrocytes were partially blocked by treatment with pyrrolidine dithiocarbamate (PDTC), a selective NF-kappaB inhibitor. pyrrolidine dithiocarbamic acid 207-234 interleukin 1 beta Rattus norvegicus 91-99 8769830-3 1996 In rat mesangial cells treated with an inhibitor of NF-kappa B, pyrrolidine dithiocarbamate, induction of MMP-9 by IL-1 beta was suppressed at both mRNA and protein levels. pyrrolidine dithiocarbamic acid 64-91 interleukin 1 beta Rattus norvegicus 115-124 7533726-2 1994 The presence of pyrrolidine dithiocarbamate, a specific inhibitor of nuclear transcription factor kappa B activation, during the exposure of the rings to interleukin-1 beta prevented these responses to interleukin-1 beta. pyrrolidine dithiocarbamic acid 16-43 interleukin 1 beta Rattus norvegicus 154-172 7533726-2 1994 The presence of pyrrolidine dithiocarbamate, a specific inhibitor of nuclear transcription factor kappa B activation, during the exposure of the rings to interleukin-1 beta prevented these responses to interleukin-1 beta. pyrrolidine dithiocarbamic acid 16-43 interleukin 1 beta Rattus norvegicus 202-220 7533726-5 1994 These observations suggest that pyrrolidine dithiocarbamate prevents the interleukin-1 beta-mediated expression of the inducible nitric oxide synthase without affecting the activity of the constitutive enzyme in the rat aorta. pyrrolidine dithiocarbamic acid 32-59 interleukin 1 beta Rattus norvegicus 73-91 7513157-0 1994 Pyrrolidine dithiocarbamate differentially affects interleukin 1 beta- and cAMP-induced nitric oxide synthase expression in rat renal mesangial cells. pyrrolidine dithiocarbamic acid 0-27 interleukin 1 beta Rattus norvegicus 51-69 7513157-3 1994 We have used pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of nuclear factor kappa B (NF kappa B), to determine its role in IL-1 beta- and cAMP-triggered NOS expression. pyrrolidine dithiocarbamic acid 13-40 interleukin 1 beta Rattus norvegicus 133-142 7513157-3 1994 We have used pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of nuclear factor kappa B (NF kappa B), to determine its role in IL-1 beta- and cAMP-triggered NOS expression. pyrrolidine dithiocarbamic acid 42-46 interleukin 1 beta Rattus norvegicus 133-142 31837574-7 2020 Moreover, PDX inhibited the increase in phosphorylated NF-kappaB p65 and IkappaBalpha upon IL-1beta stimulation, and the negative effects of IL-1beta on chondrocytes were partially blocked by treatment with pyrrolidine dithiocarbamate (PDTC), a selective NF-kappaB inhibitor. pyrrolidine dithiocarbamic acid 207-234 interleukin 1 beta Rattus norvegicus 141-149 31837574-7 2020 Moreover, PDX inhibited the increase in phosphorylated NF-kappaB p65 and IkappaBalpha upon IL-1beta stimulation, and the negative effects of IL-1beta on chondrocytes were partially blocked by treatment with pyrrolidine dithiocarbamate (PDTC), a selective NF-kappaB inhibitor. pyrrolidine dithiocarbamic acid 236-240 interleukin 1 beta Rattus norvegicus 141-149 28986307-8 2018 Dual luciferase and gel-shift assays and chromatin immunoprecipitation-polymerase chain reaction demonstrated that IL-1beta and TNF-alpha enhanced ASIC1a promoter activity in chondrocytes by increasing NF-kappaB DNA-binding activities, which was in turn prevented by the NF-kappaB inhibitor ammonium pyrrolidinedithiocarbamate. pyrrolidine dithiocarbamic acid 291-326 interleukin 1 beta Rattus norvegicus 115-123 31175933-5 2019 Furthermore, micro-injection of the NF-kappaB inhibitor pyrrolidine dithiocarbamate into PVN in MI rats, significantly inhibited the activation of NF-kappaB and further reduced the expression of IL-1beta and NGF in the PVN, finally blunting sympathetic hyperinnervation in the heart, moreover, the blockade of NF-kappaB in the PVN reduced the incidence of ventricular arrhythmias (VAs). pyrrolidine dithiocarbamic acid 56-83 interleukin 1 beta Rattus norvegicus 195-203 25412187-7 2015 In addition, pre-treatment of the cells with NaHS or PDTC ameliorated the HG-induced inflammatory response, leading to a decrease in the levels of IL-1beta, IL-6 and tumor necrosis factor-alpha (TNF-alpha). pyrrolidine dithiocarbamic acid 53-57 interleukin 1 beta Rattus norvegicus 147-155 27493629-5 2016 Herein we describe the anti-inflammatory effects of pyrrolidine dithiocarbamate (PDTC), a selective NF-kappaB inhibitor, in modulating systemic cytokines including tumor necrosis factor (TNF)-alpha and interleukin-1beta (IL-1beta) and CNS markers after LPS exposure in aged rats. pyrrolidine dithiocarbamic acid 52-79 interleukin 1 beta Rattus norvegicus 202-219 27493629-5 2016 Herein we describe the anti-inflammatory effects of pyrrolidine dithiocarbamate (PDTC), a selective NF-kappaB inhibitor, in modulating systemic cytokines including tumor necrosis factor (TNF)-alpha and interleukin-1beta (IL-1beta) and CNS markers after LPS exposure in aged rats. pyrrolidine dithiocarbamic acid 52-79 interleukin 1 beta Rattus norvegicus 221-229 27493629-5 2016 Herein we describe the anti-inflammatory effects of pyrrolidine dithiocarbamate (PDTC), a selective NF-kappaB inhibitor, in modulating systemic cytokines including tumor necrosis factor (TNF)-alpha and interleukin-1beta (IL-1beta) and CNS markers after LPS exposure in aged rats. pyrrolidine dithiocarbamic acid 81-85 interleukin 1 beta Rattus norvegicus 202-219 27493629-5 2016 Herein we describe the anti-inflammatory effects of pyrrolidine dithiocarbamate (PDTC), a selective NF-kappaB inhibitor, in modulating systemic cytokines including tumor necrosis factor (TNF)-alpha and interleukin-1beta (IL-1beta) and CNS markers after LPS exposure in aged rats. pyrrolidine dithiocarbamic acid 81-85 interleukin 1 beta Rattus norvegicus 221-229 23807148-6 2013 The inhibition of NF-kappaB by pyrrolidine dithiocarbamate (PDTC), a selective inhibitor of NF-kappaB, significantly ameliorated DOX-induced inflammation, leading to a decrease in the levels of IL-1beta and IL-6, as well as TNF-alpha production in H9c2 cells. pyrrolidine dithiocarbamic acid 31-58 interleukin 1 beta Rattus norvegicus 194-202 23933318-6 2013 Pharmacological inhibition of NF-kappaB activation by pyrrolidine dithiocarbamate markedly suppressed the IL-1beta increase and NF-kappaB signaling, and also mitigated the severity of cognitive deficits in the Morris water maze task. pyrrolidine dithiocarbamic acid 54-81 interleukin 1 beta Rattus norvegicus 106-114 23807148-6 2013 The inhibition of NF-kappaB by pyrrolidine dithiocarbamate (PDTC), a selective inhibitor of NF-kappaB, significantly ameliorated DOX-induced inflammation, leading to a decrease in the levels of IL-1beta and IL-6, as well as TNF-alpha production in H9c2 cells. pyrrolidine dithiocarbamic acid 60-64 interleukin 1 beta Rattus norvegicus 194-202 19782127-4 2010 Cellular release of IL-1alpha, IL-1beta and IL-6 was significantly attenuated by curcumin and by inhibitors of the MAPKs ERK1/2 (PD98069), p38 (SB202190) and JNK (SP600125), whereas pyrrolidine dithiocarbamate (PDTC) attenuated the release of IL-6, but not of IL-1alpha and IL-1beta. pyrrolidine dithiocarbamic acid 211-215 interleukin 1 beta Rattus norvegicus 31-39 19782127-4 2010 Cellular release of IL-1alpha, IL-1beta and IL-6 was significantly attenuated by curcumin and by inhibitors of the MAPKs ERK1/2 (PD98069), p38 (SB202190) and JNK (SP600125), whereas pyrrolidine dithiocarbamate (PDTC) attenuated the release of IL-6, but not of IL-1alpha and IL-1beta. pyrrolidine dithiocarbamic acid 182-209 interleukin 1 beta Rattus norvegicus 31-39