PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20389059-7 2010 Inhibitors of NF-kappaB (ammonium pyrrolidinedithiocarbamate and isohelenin) and an antioxidant (N-acetyl-L-cysteine) suppressed the indoxyl sulfate-induced expression of ICAM-1 and MCP-1 in HUVEC. pyrrolidine dithiocarbamic acid 25-60 intercellular adhesion molecule 1 Homo sapiens 171-177 21673371-10 2011 Experiments with HAECs pretreated with pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB, revealed that both LA and EA-mediated induction of ICAM-1 and VCAM-1 is mainly regulated by NF-kappaB. pyrrolidine dithiocarbamic acid 39-66 intercellular adhesion molecule 1 Homo sapiens 146-152 9654343-6 1998 The antioxidant pyrrolidine dithiocarbamate and the proteasome inhibitor, n-Tosyl-Phe-chloromethyl ketone, blocked both the activation of NF-kappaB and the upregulation of the ICAM-1 gene. pyrrolidine dithiocarbamic acid 16-43 intercellular adhesion molecule 1 Homo sapiens 176-182 18446055-8 2008 Finally, pretreatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB, reduced TNF-alpha-induced ICAM-1 expression and both DPI and RacN17 significantly diminished NF-kappaB activation in response to TNF-alpha. pyrrolidine dithiocarbamic acid 27-54 intercellular adhesion molecule 1 Homo sapiens 116-122 18446055-8 2008 Finally, pretreatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB, reduced TNF-alpha-induced ICAM-1 expression and both DPI and RacN17 significantly diminished NF-kappaB activation in response to TNF-alpha. pyrrolidine dithiocarbamic acid 56-60 intercellular adhesion molecule 1 Homo sapiens 116-122 14572618-1 2003 We demonstrate that two different cell-permeable antioxidants, pyrrolidine dithiocarbamate (PDTC) and dimethylthiourea (DMTU), inhibit TNFalpha-induced ICAM-1 surface and gene expression in primary cultures of differentiated normal human bronchial epithelial (NHBE) cells. pyrrolidine dithiocarbamic acid 63-90 intercellular adhesion molecule 1 Homo sapiens 152-158 14572618-1 2003 We demonstrate that two different cell-permeable antioxidants, pyrrolidine dithiocarbamate (PDTC) and dimethylthiourea (DMTU), inhibit TNFalpha-induced ICAM-1 surface and gene expression in primary cultures of differentiated normal human bronchial epithelial (NHBE) cells. pyrrolidine dithiocarbamic acid 92-96 intercellular adhesion molecule 1 Homo sapiens 152-158 11571584-6 2001 The Ad.CFTR-dependent increase of ICAM-1 mRNA was abolished by inhibitors of NF-kB, such as N-acetyl-L-cysteine, pyrrolidine dithiocarbamate, parthenolide and the synthetic peptide SN50. pyrrolidine dithiocarbamic acid 113-140 intercellular adhesion molecule 1 Homo sapiens 34-40 11046059-7 2000 Fibrin(ogen) stimulation of ICAM-1 could be suppressed by pyrrolidinedithiocarbamate, an inhibitor of NF-kappaB activation. pyrrolidine dithiocarbamic acid 58-84 intercellular adhesion molecule 1 Homo sapiens 28-34 10594564-7 1999 In a second set of experiments we were able to show that coincubation of L2 cells with pyrrolidine dithiocarbamate (PDTC) significantly suppressed neopterin-induced ICAM-1 synthesis. pyrrolidine dithiocarbamic acid 87-114 intercellular adhesion molecule 1 Homo sapiens 165-171 10594564-7 1999 In a second set of experiments we were able to show that coincubation of L2 cells with pyrrolidine dithiocarbamate (PDTC) significantly suppressed neopterin-induced ICAM-1 synthesis. pyrrolidine dithiocarbamic acid 116-120 intercellular adhesion molecule 1 Homo sapiens 165-171 12039983-6 2002 Pretreatment with pertussis toxin, GF109203X, BAPTA-AM, and pyrrolidine dithiocarbamate inhibited MCP-1-dependent IL-6 and ICAM-1 synthesis, suggesting the involvement of Gi-proteins, protein kinase C, intracellular Ca(2+), and nuclear factor-kappaB (NF-kappaB) in MCP-1 signaling. pyrrolidine dithiocarbamic acid 60-87 intercellular adhesion molecule 1 Homo sapiens 123-129 10549609-1 1999 PURPOSE: The effects of antioxidants (N-acetyl-L-cysteine [NAC] and pyrrolidine dithiocarbamate [PDTC]) on radiation-induced ICAM-1 expression on human umbilical vein endothelial cells (HUVEC) were investigated. pyrrolidine dithiocarbamic acid 68-95 intercellular adhesion molecule 1 Homo sapiens 125-131 10549609-1 1999 PURPOSE: The effects of antioxidants (N-acetyl-L-cysteine [NAC] and pyrrolidine dithiocarbamate [PDTC]) on radiation-induced ICAM-1 expression on human umbilical vein endothelial cells (HUVEC) were investigated. pyrrolidine dithiocarbamic acid 97-101 intercellular adhesion molecule 1 Homo sapiens 125-131 7545393-5 1995 We show that pyrrolidine dithiocarbamate strongly reduces the TNF alpha-mediated induction of E-selectin, VCAM-1, ICAM-1, PAI-1, tissue factor, IL-8 and I kappa B-alpha. pyrrolidine dithiocarbamic acid 13-40 intercellular adhesion molecule 1 Homo sapiens 114-120 8871659-2 1996 In this study, we show that pyrrolidine dithiocarbamate (PDTC), a potent antioxidant agent, upregulated the cell surface expression of intercellular adhesion molecule-1 (ICAM-1) in human endothelial cells (EC). pyrrolidine dithiocarbamic acid 28-55 intercellular adhesion molecule 1 Homo sapiens 135-168 8871659-2 1996 In this study, we show that pyrrolidine dithiocarbamate (PDTC), a potent antioxidant agent, upregulated the cell surface expression of intercellular adhesion molecule-1 (ICAM-1) in human endothelial cells (EC). pyrrolidine dithiocarbamic acid 28-55 intercellular adhesion molecule 1 Homo sapiens 170-176 8871659-2 1996 In this study, we show that pyrrolidine dithiocarbamate (PDTC), a potent antioxidant agent, upregulated the cell surface expression of intercellular adhesion molecule-1 (ICAM-1) in human endothelial cells (EC). pyrrolidine dithiocarbamic acid 57-61 intercellular adhesion molecule 1 Homo sapiens 135-168 8871659-2 1996 In this study, we show that pyrrolidine dithiocarbamate (PDTC), a potent antioxidant agent, upregulated the cell surface expression of intercellular adhesion molecule-1 (ICAM-1) in human endothelial cells (EC). pyrrolidine dithiocarbamic acid 57-61 intercellular adhesion molecule 1 Homo sapiens 170-176 35624646-10 2022 The expression of protein intercellular cell adhesion molecule (ICAM-1) and human beta defensin-2 (HBD2) decreased when exposed to TNF-alpha and LPS, but recovered with the NF-kappaB inhibitor treatment- Pyrrolidinedithiocarbamic acid (PDTC), indicating the stability of the fabricated chip. pyrrolidine dithiocarbamic acid 236-240 intercellular adhesion molecule 1 Homo sapiens 64-70 7642556-2 1995 The H2O2-induced increase in ICAM-1 mRNA was inhibited by actinomycin D, by the antioxidant N-acetylcysteine, and by 3-amino-benzamide (which blocks oxidant-induced AP-1 activity), but not by pyrrolidine dithiocarbamate (which blocks oxidant-induced NF-kappa B activity). pyrrolidine dithiocarbamic acid 192-219 intercellular adhesion molecule 1 Homo sapiens 29-35 35624646-10 2022 The expression of protein intercellular cell adhesion molecule (ICAM-1) and human beta defensin-2 (HBD2) decreased when exposed to TNF-alpha and LPS, but recovered with the NF-kappaB inhibitor treatment- Pyrrolidinedithiocarbamic acid (PDTC), indicating the stability of the fabricated chip. pyrrolidine dithiocarbamic acid 204-234 intercellular adhesion molecule 1 Homo sapiens 64-70 7532665-0 1995 Pyrrolidine dithiocarbamate inhibits intercellular adhesion molecule-1 biosynthesis induced by cytokines in human fibroblasts. pyrrolidine dithiocarbamic acid 0-27 intercellular adhesion molecule 1 Homo sapiens 37-70 7532665-3 1995 In this report, we investigated the effects of dexamethasone, cyclosporin A, FK506, and pyrrolidine dithiocarbamate (PDTC) on the induction of the ICAM-1 gene by cytokines in fibroblasts. pyrrolidine dithiocarbamic acid 88-115 intercellular adhesion molecule 1 Homo sapiens 147-153 7532665-3 1995 In this report, we investigated the effects of dexamethasone, cyclosporin A, FK506, and pyrrolidine dithiocarbamate (PDTC) on the induction of the ICAM-1 gene by cytokines in fibroblasts. pyrrolidine dithiocarbamic acid 117-121 intercellular adhesion molecule 1 Homo sapiens 147-153 7798616-3 1994 Expression of ICAM-1 was induced on keratinocytes by treatment with 300 microM H2O2 for 1 h. The antioxidant N-acetyl-L-cysteine strongly inhibited H2O2-induced ICAM-1 expression, whereas the antioxidants pyrrolidine dithiocarbamate and alpha-tocopherol were less inhibitory. pyrrolidine dithiocarbamic acid 205-232 intercellular adhesion molecule 1 Homo sapiens 14-20 7798616-4 1994 N-acetyl-L-cysteine also suppressed keratinocyte surface expression of ICAM-1 induced by the cytokines interferon-gamma (IFN-gamma) or tumor necrosis factor-alpha (TNF-alpha), whereas pyrrolidine dithiocarbamate and alpha-tocopherol suppressed IFN-gamma-induced surface expression but not TNF-alpha-induced expression. pyrrolidine dithiocarbamic acid 184-211 intercellular adhesion molecule 1 Homo sapiens 71-77 24134657-12 2014 ICAM-1 and VCAM-1 expressions were also reduced by antioxidants such as pyrrolidine dithiocarbamate, diphenylene iodonium and apocynin. pyrrolidine dithiocarbamic acid 72-99 intercellular adhesion molecule 1 Homo sapiens 0-6 24363440-12 2014 Pyrrolidinedithiocarbamic acid, an inhibitor of NF-kappaB, abolished the elevation of ICAM1 but not COX2. pyrrolidine dithiocarbamic acid 0-30 intercellular adhesion molecule 1 Homo sapiens 86-91