PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33728865-0 2021 PDTC ameliorates neuropathic pain by inhibiting microglial activation via blockage of the TNFalpha-CX3CR1 pathway. pyrrolidine dithiocarbamic acid 0-4 tumor necrosis factor Rattus norvegicus 99-107 33728865-1 2021 Previous studies have suggested that pyrrolidine dithiocarbamate (PDTC), a nuclear factor kappaB (NF-kappaB) inhibitor, play a role in deterring nerve injury-induced neuropathic pain (NP) The activation of NF-kappaB pathway may contribute to spinal microglial activation, CX3CR1 and tumor necrosis factor-alpha (TNF-a) up-regulation. pyrrolidine dithiocarbamic acid 37-64 tumor necrosis factor Rattus norvegicus 283-310 33728865-1 2021 Previous studies have suggested that pyrrolidine dithiocarbamate (PDTC), a nuclear factor kappaB (NF-kappaB) inhibitor, play a role in deterring nerve injury-induced neuropathic pain (NP) The activation of NF-kappaB pathway may contribute to spinal microglial activation, CX3CR1 and tumor necrosis factor-alpha (TNF-a) up-regulation. pyrrolidine dithiocarbamic acid 37-64 tumor necrosis factor Rattus norvegicus 312-317 33728865-1 2021 Previous studies have suggested that pyrrolidine dithiocarbamate (PDTC), a nuclear factor kappaB (NF-kappaB) inhibitor, play a role in deterring nerve injury-induced neuropathic pain (NP) The activation of NF-kappaB pathway may contribute to spinal microglial activation, CX3CR1 and tumor necrosis factor-alpha (TNF-a) up-regulation. pyrrolidine dithiocarbamic acid 66-70 tumor necrosis factor Rattus norvegicus 283-310 33728865-1 2021 Previous studies have suggested that pyrrolidine dithiocarbamate (PDTC), a nuclear factor kappaB (NF-kappaB) inhibitor, play a role in deterring nerve injury-induced neuropathic pain (NP) The activation of NF-kappaB pathway may contribute to spinal microglial activation, CX3CR1 and tumor necrosis factor-alpha (TNF-a) up-regulation. pyrrolidine dithiocarbamic acid 66-70 tumor necrosis factor Rattus norvegicus 312-317 33728865-2 2021 The aim of this study was to clarify whether PDTC could inhibit the development of neuropathic pain via decreasing TNF-a-induced CX3CR1 up-regulation. pyrrolidine dithiocarbamic acid 45-49 tumor necrosis factor Rattus norvegicus 115-120 33728865-9 2021 Pain behavior and immunohistochemistry results showed that intrathecal infusion of PDTC at 100 or 1000 pmol/d prevented the development of mechanical and thermal hyperalgesia, spinal microglial activation and TNF-a expression induced by sciatic nerve CCI in rats. pyrrolidine dithiocarbamic acid 83-87 tumor necrosis factor Rattus norvegicus 209-214 33728865-11 2021 In conclusion, intrathecal infusion of PDTC could attenuate the pain-related behaviors induced by sciatic nerve CCI through suppressing the spinal microglia activation and TNF-a up-regulation in rats. pyrrolidine dithiocarbamic acid 39-43 tumor necrosis factor Rattus norvegicus 172-177 33380567-11 2021 TAK242 or NF-kappaB inhibitor pyrrolidinedithiocarbamic acid alleviated mechanical and thermal pain behaviors, inhibited spinal microglia activation, moderated spinal inflammatory response manifested by decreasing interleukin (IL)-1beta, IL-6, tumor necrosis factor-alpha expression and increasing IL-10 expression in the spinal dorsal horn. pyrrolidine dithiocarbamic acid 30-60 tumor necrosis factor Rattus norvegicus 244-271 31746430-7 2020 PDTC (50 mg/kg/day) was intraperitoneally injected 2 h after the co-administration of INH and RIF to compare liver biochemical indicators in the serum, histopathological damage, NF-kappaB activity, oxidative stress, hepatic mRNA expression of tumor necrosis factor (TNF)-alpha, bile salt export pump (BSEP), and protein expression of BSEP. pyrrolidine dithiocarbamic acid 0-4 tumor necrosis factor Rattus norvegicus 243-276 32848796-7 2020 Furthermore, pyrrolidinedithiocarbamate (PDTC, a selective inhibitor of NF-kappaB p65) not only alleviated the OGD/R-induced HBMVECs injury and permeability, but also reduced the expression of TNF-alpha, IL-6, IL-1beta, p-p65, and p-IkappaB, and the protective effect of PDTC was equivalent to that of TPPU. pyrrolidine dithiocarbamic acid 13-39 tumor necrosis factor Rattus norvegicus 193-202 32848796-7 2020 Furthermore, pyrrolidinedithiocarbamate (PDTC, a selective inhibitor of NF-kappaB p65) not only alleviated the OGD/R-induced HBMVECs injury and permeability, but also reduced the expression of TNF-alpha, IL-6, IL-1beta, p-p65, and p-IkappaB, and the protective effect of PDTC was equivalent to that of TPPU. pyrrolidine dithiocarbamic acid 41-45 tumor necrosis factor Rattus norvegicus 193-202 32848796-7 2020 Furthermore, pyrrolidinedithiocarbamate (PDTC, a selective inhibitor of NF-kappaB p65) not only alleviated the OGD/R-induced HBMVECs injury and permeability, but also reduced the expression of TNF-alpha, IL-6, IL-1beta, p-p65, and p-IkappaB, and the protective effect of PDTC was equivalent to that of TPPU. pyrrolidine dithiocarbamic acid 271-275 tumor necrosis factor Rattus norvegicus 193-202 31746430-8 2020 It was found that the inhibition of NF-kappaB activation by PDTC treatment markedly alleviated liver biochemical and histological injury, decreased oxidative stress and mRNA levels of TNF-alpha, and prevented decreases in BSEP mRNA and protein expression induced by the co-administration of INH and RIF. pyrrolidine dithiocarbamic acid 60-64 tumor necrosis factor Rattus norvegicus 184-193 30468489-12 2018 The levels of TNF-alpha, IL-1beta, IL-6 and IL-8 in PDTC group were significantly lower than in OL group (p<0.05). pyrrolidine dithiocarbamic acid 52-56 tumor necrosis factor Rattus norvegicus 14-23 29950992-9 2018 The negative effects of TNF-alpha on chondrocytes can be partially blocked by treating with icariin or ammonium pyrrolidinedithiocarbamate (PDTC, an NF-kappaB inhibitor). pyrrolidine dithiocarbamic acid 103-138 tumor necrosis factor Rattus norvegicus 24-33 29940243-12 2018 Pyrrolidine dithiocarbamate (PDTC), a NF-kappaB inhibitor, prevented the response not only in TNF-alpha-treated cardiomyocytes but also in H/R-treated group. pyrrolidine dithiocarbamic acid 0-27 tumor necrosis factor Rattus norvegicus 94-103 29940243-12 2018 Pyrrolidine dithiocarbamate (PDTC), a NF-kappaB inhibitor, prevented the response not only in TNF-alpha-treated cardiomyocytes but also in H/R-treated group. pyrrolidine dithiocarbamic acid 29-33 tumor necrosis factor Rattus norvegicus 94-103 29950992-9 2018 The negative effects of TNF-alpha on chondrocytes can be partially blocked by treating with icariin or ammonium pyrrolidinedithiocarbamate (PDTC, an NF-kappaB inhibitor). pyrrolidine dithiocarbamic acid 140-144 tumor necrosis factor Rattus norvegicus 24-33 28986307-8 2018 Dual luciferase and gel-shift assays and chromatin immunoprecipitation-polymerase chain reaction demonstrated that IL-1beta and TNF-alpha enhanced ASIC1a promoter activity in chondrocytes by increasing NF-kappaB DNA-binding activities, which was in turn prevented by the NF-kappaB inhibitor ammonium pyrrolidinedithiocarbamate. pyrrolidine dithiocarbamic acid 291-326 tumor necrosis factor Rattus norvegicus 128-137 28901421-8 2017 Subsequent experiments confirmed that the p38 mitogen-activated protein kinase (MAPK) inhibitor, SB203580, and nuclear factor (NF)-kappaB inhibitor, pyrrolidine dithiocarbamate, eliminated the uric acid-induced expression of TNF-alpha. pyrrolidine dithiocarbamic acid 149-176 tumor necrosis factor Rattus norvegicus 225-234 27493629-5 2016 Herein we describe the anti-inflammatory effects of pyrrolidine dithiocarbamate (PDTC), a selective NF-kappaB inhibitor, in modulating systemic cytokines including tumor necrosis factor (TNF)-alpha and interleukin-1beta (IL-1beta) and CNS markers after LPS exposure in aged rats. pyrrolidine dithiocarbamic acid 52-79 tumor necrosis factor Rattus norvegicus 164-197 27959400-10 2017 Pretreatment of the in vitro resistin-treated AP model with the NF-kappaB inhibitor, pyrrolidine dithiocarbamate decreased the protein expression of the NF-kappaB p65 subunit in nuclei, and significantly attenuated the increased mRNA expression levels of TNF-alpha and IL-6 induced by resistin. pyrrolidine dithiocarbamic acid 85-112 tumor necrosis factor Rattus norvegicus 255-264 27493629-5 2016 Herein we describe the anti-inflammatory effects of pyrrolidine dithiocarbamate (PDTC), a selective NF-kappaB inhibitor, in modulating systemic cytokines including tumor necrosis factor (TNF)-alpha and interleukin-1beta (IL-1beta) and CNS markers after LPS exposure in aged rats. pyrrolidine dithiocarbamic acid 81-85 tumor necrosis factor Rattus norvegicus 164-197 24663080-7 2014 Finally, pyrrolidine dithiocarbamate also reduced the levels of IL-6 and TNF-alpha and the activation of NF-kappaB. pyrrolidine dithiocarbamic acid 9-36 tumor necrosis factor Rattus norvegicus 73-82 25412187-7 2015 In addition, pre-treatment of the cells with NaHS or PDTC ameliorated the HG-induced inflammatory response, leading to a decrease in the levels of IL-1beta, IL-6 and tumor necrosis factor-alpha (TNF-alpha). pyrrolidine dithiocarbamic acid 53-57 tumor necrosis factor Rattus norvegicus 166-193 25412187-7 2015 In addition, pre-treatment of the cells with NaHS or PDTC ameliorated the HG-induced inflammatory response, leading to a decrease in the levels of IL-1beta, IL-6 and tumor necrosis factor-alpha (TNF-alpha). pyrrolidine dithiocarbamic acid 53-57 tumor necrosis factor Rattus norvegicus 195-204 23807148-6 2013 The inhibition of NF-kappaB by pyrrolidine dithiocarbamate (PDTC), a selective inhibitor of NF-kappaB, significantly ameliorated DOX-induced inflammation, leading to a decrease in the levels of IL-1beta and IL-6, as well as TNF-alpha production in H9c2 cells. pyrrolidine dithiocarbamic acid 31-58 tumor necrosis factor Rattus norvegicus 224-233 23807148-6 2013 The inhibition of NF-kappaB by pyrrolidine dithiocarbamate (PDTC), a selective inhibitor of NF-kappaB, significantly ameliorated DOX-induced inflammation, leading to a decrease in the levels of IL-1beta and IL-6, as well as TNF-alpha production in H9c2 cells. pyrrolidine dithiocarbamic acid 60-64 tumor necrosis factor Rattus norvegicus 224-233 22972875-9 2012 Pyrrolidine dithiocarbamate inhibited nuclear localization of NF-kappaBp65 and subsequent downregulation of the transcription and secretion of TNF-alpha and IL-6. pyrrolidine dithiocarbamic acid 0-27 tumor necrosis factor Rattus norvegicus 143-152 17762659-4 2007 Pyrrolidine dithiocarbamate (PDTC) (100 mg/kg per day), an NF-kappaB inhibitor, abolished Ang II-induced NF-kappaB activation and concomitant increase in tumor necrosis factor-alpha gene expression, while activator protein-1/DNA binding was not affected. pyrrolidine dithiocarbamic acid 0-27 tumor necrosis factor Rattus norvegicus 154-181 20562516-6 2010 An Akt inhibitor, LY294002, and an NF-kappaB inhibitor, pyrrolidine dithiocarbamate, inhibited TNF-induced VCAM-1. pyrrolidine dithiocarbamic acid 56-83 tumor necrosis factor Rattus norvegicus 95-98 19997973-10 2010 Compared to the severe acute pancreatitis group, the pancreas nuclear factor-kappaB activity, tumor necrosis factor-alpha, high-mobility group box protein-1 levels in the pyrrolidine dithiocarbamate-treated group all remarkably decreased (p<0.05). pyrrolidine dithiocarbamic acid 171-198 tumor necrosis factor Rattus norvegicus 94-121 19997973-12 2010 Pyrrolidine dithiocarbamate might inhibit the activation of nuclear factor-kappaB to blockade tumor necrosis factor-alpha, thereby indirectly suppressing the high-mobility group box protein-1 and reducing pancreatic tissue damage in rats with severe acute pancreatitis. pyrrolidine dithiocarbamic acid 0-27 tumor necrosis factor Rattus norvegicus 94-121 17762659-4 2007 Pyrrolidine dithiocarbamate (PDTC) (100 mg/kg per day), an NF-kappaB inhibitor, abolished Ang II-induced NF-kappaB activation and concomitant increase in tumor necrosis factor-alpha gene expression, while activator protein-1/DNA binding was not affected. pyrrolidine dithiocarbamic acid 29-33 tumor necrosis factor Rattus norvegicus 154-181 16871588-7 2006 Inhibition of p38 and NF-kappaB activation by SB203580 and pyrrolidine dithiocarbamate, respectively, blocked endotoxin-induced H(2)O(2), NO, TNF-alpha, and IL-6 synthesis. pyrrolidine dithiocarbamic acid 59-86 tumor necrosis factor Rattus norvegicus 142-151 15954894-13 2005 Pretreatment of the cells with NF-kappaB inhibitor pyrrolidine dithio-carbamate (PDTC) blocked the productions of IL-1beta, IL-6, and activation of NF-kappaB induced by TNF-alpha. pyrrolidine dithiocarbamic acid 51-79 tumor necrosis factor Rattus norvegicus 169-178 16771850-6 2006 TNF- and LPS- induced CXCL2 gene expression and protein release were completely blocked by pyrrolidine dithiocarbamate (PDTC) and helenalin, two potent NF-kappaB inhibitors. pyrrolidine dithiocarbamic acid 91-118 tumor necrosis factor Rattus norvegicus 0-3 16771850-6 2006 TNF- and LPS- induced CXCL2 gene expression and protein release were completely blocked by pyrrolidine dithiocarbamate (PDTC) and helenalin, two potent NF-kappaB inhibitors. pyrrolidine dithiocarbamic acid 120-124 tumor necrosis factor Rattus norvegicus 0-3 15954894-13 2005 Pretreatment of the cells with NF-kappaB inhibitor pyrrolidine dithio-carbamate (PDTC) blocked the productions of IL-1beta, IL-6, and activation of NF-kappaB induced by TNF-alpha. pyrrolidine dithiocarbamic acid 81-85 tumor necrosis factor Rattus norvegicus 169-178 12892381-5 2003 On the other hand, the enhanced release of TNF-alpha was completely suppressed by U73122, and strongly suppressed by TMB-8 (which inhibits calcium release from the endoplasmic reticulum) and W-7, and weakly suppressed by pyrrolidine dithiocarbamate (a NF-kappaB inhibitor). pyrrolidine dithiocarbamic acid 221-248 tumor necrosis factor Rattus norvegicus 43-52 15481297-3 2004 Because NF-kappaB is activated by both LPS and ROS, we hypothesized that an inhibitor of NF-kappaB, pyrrolidine dithiocarbamate (PDTC), would block release of TNF from the heart stimulated by these two agents. pyrrolidine dithiocarbamic acid 100-127 tumor necrosis factor Rattus norvegicus 159-162 15481297-3 2004 Because NF-kappaB is activated by both LPS and ROS, we hypothesized that an inhibitor of NF-kappaB, pyrrolidine dithiocarbamate (PDTC), would block release of TNF from the heart stimulated by these two agents. pyrrolidine dithiocarbamic acid 129-133 tumor necrosis factor Rattus norvegicus 159-162 12635866-6 2002 Pyrrolidine dithiocarbamate (an inhibitor of NF-kappaB) prevented the elevation of TNF-alpha mRNA levels induced by low-Mg2+ medium without LPS-stimulation, but had no suppressive effect on IL-1beta mRNA levels. pyrrolidine dithiocarbamic acid 0-27 tumor necrosis factor Rattus norvegicus 83-92 12642397-6 2003 (3) The ubiquitin/proteosome inhibitors, MG132 (10 micro M) and pyrrolidine dithiocarbamate (200 micro M), suppressed activation of NF-kappaB as well as stimulation of fractalkine mRNA and protein expression by TNF-alpha. pyrrolidine dithiocarbamic acid 64-91 tumor necrosis factor Rattus norvegicus 211-220 11578593-9 2001 Application of pyrrolidine dithiocarbamate, an inhibitor of nuclear factor-kB (NF-kappaB), prior to LPS stimulation not only prevented up-regulation of NF-kappaB gene expression, but also completely blocked up-regulation of pro-inflammatory cytokine genes (TNF-alpha and interleukin-1beta) and two chemokine genes: CXC chemokine LIX and CC chemokine MIP-3 alpha. pyrrolidine dithiocarbamic acid 15-42 tumor necrosis factor Rattus norvegicus 257-266 10956637-6 2000 Gel shift and Western blot analyses confirmed that TNF-alpha activated NF-kappaB and depleted IkappaB in this system and that these effects were prevented by MG-132 and pyrrolidine dithiocarbamate. pyrrolidine dithiocarbamic acid 169-196 tumor necrosis factor Rattus norvegicus 51-60 10203355-10 1999 Pyrrolidine dithiocarbamate (PDTC), N-acetyl-L-cysteine, dexamethasone (Dex), HerA, and AG490 partially inhibited LPS/ IFN-gamma- or TNF-alpha/IFN-gamma-induced nitrite production. pyrrolidine dithiocarbamic acid 0-27 tumor necrosis factor Rattus norvegicus 133-142 10505757-5 1999 Pyrrolidine dithiocarbamate, a potent inhibitor of NF-kappaB activation, attenuated the macrophage TNF-alpha production by PAAF. pyrrolidine dithiocarbamic acid 0-27 tumor necrosis factor Rattus norvegicus 99-108 10433212-7 1999 Different types of NF-kappaB inhibitors, pyrrolidine dithiocarbamate and MG132, which specifically abolished IkappaB degradation and subsequent NF-kappaB activation by LPS, suppressed TNF alpha secretion from VSMC. pyrrolidine dithiocarbamic acid 41-68 tumor necrosis factor Rattus norvegicus 184-193 10433212-10 1999 TNF alpha messenger RNA expression induced by LPS was inhibited by pyrrolidine dithiocarbamate, MG132, and SB203580, but not by PD98059. pyrrolidine dithiocarbamic acid 67-94 tumor necrosis factor Rattus norvegicus 0-9 34446210-6 2021 Pyrrolidine dithiocarbamate (PDTC), NF-kappaB inhibitor, did not alter CYP2E1 but mitigated free radical generation, SOD activity, LPO, nitrite content, iNOS activity/expression and levels of pro-inflammatory cytokines (tumor necrosis factor-alpha, interleukine-1beta and interleukine-4). pyrrolidine dithiocarbamic acid 0-27 tumor necrosis factor Rattus norvegicus 220-247 34446210-6 2021 Pyrrolidine dithiocarbamate (PDTC), NF-kappaB inhibitor, did not alter CYP2E1 but mitigated free radical generation, SOD activity, LPO, nitrite content, iNOS activity/expression and levels of pro-inflammatory cytokines (tumor necrosis factor-alpha, interleukine-1beta and interleukine-4). pyrrolidine dithiocarbamic acid 29-33 tumor necrosis factor Rattus norvegicus 220-247