PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11358991-6 2001 Pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB activation, attenuated approximately 70% of IL-8 release evoked by IL-1beta, TNF-alpha, or ONOO(-). pyrrolidine dithiocarbamic acid 0-27 interleukin 1 beta Homo sapiens 122-130 11282781-4 2001 An inhibitor of NF-kappaB activation, pyrrolidine dithiocarbamate, and a p38 MAPK inhibitor, blocked the IL-1beta-induced H(1)R desensitization, whereas anisomycin, an SAPK/JNK and p38 MAPK activator, mimicked the effect of IL-1beta. pyrrolidine dithiocarbamic acid 38-65 interleukin 1 beta Homo sapiens 105-113 11264769-13 2001 An inhibition of NF-kappaB by pyrrolidine dithiocarbamate attenuated IL-1beta and TNF-alpha synthesis. pyrrolidine dithiocarbamic acid 30-57 interleukin 1 beta Homo sapiens 69-77 10619820-10 2000 Inhibition of NF-kappaB by pyrrolidine dithiocarbamate attenuated IL-1beta and TNF-alpha synthesis. pyrrolidine dithiocarbamic acid 27-54 interleukin 1 beta Homo sapiens 66-74 10617676-4 2000 The PKC inhibitors (Go 6976 and Ro 31-8220) and NF-kappaB inhibitor, pyrrolidine dithiocarbamate, also attenuated IL-1beta-induced PGE(2) release and COX-2 expression. pyrrolidine dithiocarbamic acid 69-96 interleukin 1 beta Homo sapiens 114-122 10564154-8 1999 In contrast to NAC, the metal chelators pyrrolidine dithiocarbamate and diethyldithiocarbamate attenuated IL-1beta-induced NF-kappaB activation but had no effect on intracellular sulfhydryl content. pyrrolidine dithiocarbamic acid 40-67 interleukin 1 beta Homo sapiens 106-114 9721692-15 1998 in the PGIS inactivation was supported by the fact that deferoxamine, pyrrolidinedithiocarbamate, DMSO, mannitol, and captopril antagonized the effect of IL-1beta on PGIS to different degrees. pyrrolidine dithiocarbamic acid 70-96 interleukin 1 beta Homo sapiens 154-162 9665590-3 1998 NF-kappaB involvement was suggested by the finding that pyrrolidinedithiocarbamate, a known inhibitor of NF-kappaB activation, blocked LPS- and IL-1beta-induced IL-8 production. pyrrolidine dithiocarbamic acid 56-82 interleukin 1 beta Homo sapiens 144-152 9593764-10 1998 This correlation was further confirmed by reporter gene assays which showed that this NF-kappaB-like sequence, in the B1-receptor promoter context, could contribute to IL-1beta and DLBK-induced B1-receptor transcription activation, and by the effect of NF-kappaB inhibitor pyrrolidinedithiocarbamate which diminished both B1-receptor upregulation and NF-kappaB activation. pyrrolidine dithiocarbamic acid 273-299 interleukin 1 beta Homo sapiens 168-176 9523575-5 1998 Whereas the antioxidant pyrrolidinedithiocarbamate was only able to inhibit IL-1beta-induced IL-6 expression, inhibition of protein kinase C prevented IL-6 expression induced by all three substances. pyrrolidine dithiocarbamic acid 24-50 interleukin 1 beta Homo sapiens 76-84 8928785-2 1996 Induction of iNOS transcription?by a combination of the cytokines interferon-gamma and IL-1 beta was inhibited by genistein, pyrrolidine dithiocarbamate, or dexamethasone and unaffected by pretreatment with ethylene glycol-bis(beta-aminoethyl ether)-N, N,N",N"-tetraacetic acid, basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), or the isoflavone daidzein. pyrrolidine dithiocarbamic acid 125-152 interleukin 1 beta Homo sapiens 87-96 7500055-10 1995 Exposure of OA-affected cartilage to interleukin 1 beta, tumor necrosis factor-alpha, and lipopolysaccharide resulted in approximately 20-50% augmentation of nitrite accumulation, which was also sensitive to cycloheximide and pyrrolidine dithiocarbamate. pyrrolidine dithiocarbamic acid 226-253 interleukin 1 beta Homo sapiens 37-84 7539260-1 1995 We presently investigated the effects of pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of nuclear factor kappa B (NF-kappa B), on the induction of nitric oxide synthase (iNOS) and manganese superoxide dismutase (MnSOD) mRNAs by IL-1 beta in insulin-producing RIN cells. pyrrolidine dithiocarbamic acid 41-68 interleukin 1 beta Homo sapiens 237-246 7539260-1 1995 We presently investigated the effects of pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of nuclear factor kappa B (NF-kappa B), on the induction of nitric oxide synthase (iNOS) and manganese superoxide dismutase (MnSOD) mRNAs by IL-1 beta in insulin-producing RIN cells. pyrrolidine dithiocarbamic acid 70-74 interleukin 1 beta Homo sapiens 237-246 7691889-3 1993 In cultured human umbilical vein endothelial (HUVE) cells, the cytokine interleukin 1 beta (IL-1 beta) activated VCAM-1 gene expression through a mechanism that was repressed approximately 90% by the antioxidants pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC). pyrrolidine dithiocarbamic acid 213-240 interleukin 1 beta Homo sapiens 72-90 7691889-3 1993 In cultured human umbilical vein endothelial (HUVE) cells, the cytokine interleukin 1 beta (IL-1 beta) activated VCAM-1 gene expression through a mechanism that was repressed approximately 90% by the antioxidants pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC). pyrrolidine dithiocarbamic acid 213-240 interleukin 1 beta Homo sapiens 92-101 7691889-3 1993 In cultured human umbilical vein endothelial (HUVE) cells, the cytokine interleukin 1 beta (IL-1 beta) activated VCAM-1 gene expression through a mechanism that was repressed approximately 90% by the antioxidants pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC). pyrrolidine dithiocarbamic acid 242-246 interleukin 1 beta Homo sapiens 72-90 7691889-3 1993 In cultured human umbilical vein endothelial (HUVE) cells, the cytokine interleukin 1 beta (IL-1 beta) activated VCAM-1 gene expression through a mechanism that was repressed approximately 90% by the antioxidants pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC). pyrrolidine dithiocarbamic acid 242-246 interleukin 1 beta Homo sapiens 92-101 28634844-8 2017 Additional experiments showed that Pyrrolidine dithiocarbamate (PDTC) inhibited IL-6, IL-1beta, and TNF-alpha expression induced by overexpression of TSP-1, accompanying with downregulation of phosphorylated p65 and IkappaBalpha protein levels in response to P. gingivalis LPS. pyrrolidine dithiocarbamic acid 35-62 interleukin 1 beta Homo sapiens 86-94 28634844-8 2017 Additional experiments showed that Pyrrolidine dithiocarbamate (PDTC) inhibited IL-6, IL-1beta, and TNF-alpha expression induced by overexpression of TSP-1, accompanying with downregulation of phosphorylated p65 and IkappaBalpha protein levels in response to P. gingivalis LPS. pyrrolidine dithiocarbamic acid 64-68 interleukin 1 beta Homo sapiens 86-94 28527816-10 2017 In addition, blocking NFkappaB signaling with the specific NFkappaB inhibitor PDTC (pyrrolidine dithiocarbamate) prevented IL-1beta-induced HUVEC activation enhanced by ADAR1 knockdown. pyrrolidine dithiocarbamic acid 84-111 interleukin 1 beta Homo sapiens 123-131 19921217-4 2010 METHODS: The influence of NFkappaB inhibitors (dexamethasone, pyrrolidine dithiocarbamate (PDTC) and BAY 11-7082) on IL-1beta-induced NFkappaB transcriptional activity was investigated by transient transfection of Caco-2 cells with an NFkappaB-secreted alkaline phosphatase reporter plasmid. pyrrolidine dithiocarbamic acid 62-89 interleukin 1 beta Homo sapiens 117-125 19921217-4 2010 METHODS: The influence of NFkappaB inhibitors (dexamethasone, pyrrolidine dithiocarbamate (PDTC) and BAY 11-7082) on IL-1beta-induced NFkappaB transcriptional activity was investigated by transient transfection of Caco-2 cells with an NFkappaB-secreted alkaline phosphatase reporter plasmid. pyrrolidine dithiocarbamic acid 91-95 interleukin 1 beta Homo sapiens 117-125 19379726-0 2009 Pyrrolidine dithiocarbamate, a NF-kappaB inhibitor, upregulates MMP-1 and MMP-13 in IL-1beta-stimulated rheumatoid arthritis fibroblast-like synoviocytes. pyrrolidine dithiocarbamic acid 0-27 interleukin 1 beta Homo sapiens 84-92 19379726-2 2009 The objective of this study was to determine the effects of the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) on the expression of MMPs in IL-1beta-stimulated fibroblast-like synoviocytes (FLSs) of rheumatoid arthritis patients. pyrrolidine dithiocarbamic acid 84-111 interleukin 1 beta Homo sapiens 148-156 19379726-2 2009 The objective of this study was to determine the effects of the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) on the expression of MMPs in IL-1beta-stimulated fibroblast-like synoviocytes (FLSs) of rheumatoid arthritis patients. pyrrolidine dithiocarbamic acid 113-117 interleukin 1 beta Homo sapiens 148-156 19513610-1 2009 In order to find new drugs to inhibit nitric oxide (NO) production, the effects of pyrrolidine dithiocarbamate (PDTC), a nuclear factor-kappa B (NF-kappaB) inhibitor, on recombinant human interleukin-1beta (rhIL-1beta)-induced NO production in chondrocytes were investigated. pyrrolidine dithiocarbamic acid 83-110 interleukin 1 beta Homo sapiens 188-205 18163503-4 2008 METHODS: Human articular chondrocytes were treated with IL-1beta in the presence of TGFbeta1, pyrrolidine dithiocarbamate (a repressor of the NF-kappaB pathway), or cycloheximide. pyrrolidine dithiocarbamic acid 94-121 interleukin 1 beta Homo sapiens 56-64 17765224-7 2007 ROS scavengers, pyrrolidinedithiocarbamate (PDTC) and N-acetyl-cysteine (NAC), reduced the levels of ROS induced by TNF-alpha, IL-1 beta and IFN-gamma (P<0.05). pyrrolidine dithiocarbamic acid 16-42 interleukin 1 beta Homo sapiens 127-136 17765224-7 2007 ROS scavengers, pyrrolidinedithiocarbamate (PDTC) and N-acetyl-cysteine (NAC), reduced the levels of ROS induced by TNF-alpha, IL-1 beta and IFN-gamma (P<0.05). pyrrolidine dithiocarbamic acid 44-48 interleukin 1 beta Homo sapiens 127-136 17608808-4 2007 The release of interleukin-1beta and interleukin-6, nuclear translocation of NF-kappaB and its DNA binding activity in the SEC1-stimulated PBMC were time-dependent and were completely eliminated by pyrrolidine dithiocarbamate or SN-50 (NF-kappaB inhibitors). pyrrolidine dithiocarbamic acid 198-225 interleukin 1 beta Homo sapiens 15-32 17314215-8 2007 The production of IL-1beta, IL-6 and IL-8 induced by TNF-alpha was decreased by pyrrolidine dithiocarbamate (PDTC), a chemical inhibitor of NF-kappaB. pyrrolidine dithiocarbamic acid 80-107 interleukin 1 beta Homo sapiens 18-26 17314215-8 2007 The production of IL-1beta, IL-6 and IL-8 induced by TNF-alpha was decreased by pyrrolidine dithiocarbamate (PDTC), a chemical inhibitor of NF-kappaB. pyrrolidine dithiocarbamic acid 109-113 interleukin 1 beta Homo sapiens 18-26 17135302-6 2007 In contrast, NF-kappaB inhibition by pyrrolidine dithiocarbamate and MG132 prevented the suppression of ABCA1 by IL-1beta. pyrrolidine dithiocarbamic acid 37-64 interleukin 1 beta Homo sapiens 113-121 17372023-8 2007 NF-kappaB inhibitors, pyrrolidine dithiocarbamate and curcumin, prevented the IL-1beta-induced increase in Caco-2 TJ permeability. pyrrolidine dithiocarbamic acid 22-49 interleukin 1 beta Homo sapiens 78-86 17386086-11 2007 Similarly, inhibitors of NF-kappaB signaling (pyrrolidine dithiocarbamate, MG-132, and SN-50) abolished the suppressive effect of IL-1. pyrrolidine dithiocarbamic acid 46-73 interleukin 1 beta Homo sapiens 130-134 16723203-6 2006 Pyrrolidine dithiocarbamate (PDTC) blocks IL-1beta induced HAS1 activation entirely. pyrrolidine dithiocarbamic acid 29-33 interleukin 1 beta Homo sapiens 42-50 16723203-0 2006 The NF-kappaB inhibitor pyrrolidine dithiocarbamate blocks IL-1beta induced hyaluronan synthase 1 (HAS1) mRNA transcription, pointing at NF-kappaB dependence of the gene HAS1. pyrrolidine dithiocarbamic acid 24-51 interleukin 1 beta Homo sapiens 59-67 16723203-6 2006 Pyrrolidine dithiocarbamate (PDTC) blocks IL-1beta induced HAS1 activation entirely. pyrrolidine dithiocarbamic acid 0-27 interleukin 1 beta Homo sapiens 42-50 16109311-4 2005 Interestingly, both IL-1beta and TNF-alpha markedly inhibited the expression of MOG, CNPase, and PLP but not MBP, the effect that was blocked by antioxidants such as N-acetylcysteine (NAC) and pyrrolidine dithiocarbamate (PDTC). pyrrolidine dithiocarbamic acid 193-220 interleukin 1 beta Homo sapiens 20-28 16109311-4 2005 Interestingly, both IL-1beta and TNF-alpha markedly inhibited the expression of MOG, CNPase, and PLP but not MBP, the effect that was blocked by antioxidants such as N-acetylcysteine (NAC) and pyrrolidine dithiocarbamate (PDTC). pyrrolidine dithiocarbamic acid 222-226 interleukin 1 beta Homo sapiens 20-28 15489374-5 2005 IL-1beta-induced VCAM-1 expression was significantly blocked by the specific NF-kappaB inhibitors helenalin and pyrrolidine dithiocarbamate. pyrrolidine dithiocarbamic acid 112-139 interleukin 1 beta Homo sapiens 0-8 15240151-7 2004 Importantly, IL-1beta-induced HBD-2 mRNA expression was inhibited by blockage of NF-kappaB activation using NF-kappaB inhibitors, including pyrrolidine dithiocarbamate and MG132. pyrrolidine dithiocarbamic acid 140-167 interleukin 1 beta Homo sapiens 13-21 15532722-8 2004 Both the fever and the increased levels of IL-1beta, IL-6, and TNF-alpha in supernatant fluids obtained from the SEA-stimulated PBMC were decreased by incubating SEA-PBMC with either PDTC, Pyri, NAC, or Cur. pyrrolidine dithiocarbamic acid 183-187 interleukin 1 beta Homo sapiens 43-51 15067222-8 2004 IL-1beta-induced COX-2 expression and PGE(2) synthesis were inhibited by the NF-kappaB inhibitor pyrrolidinedithiocarbamate. pyrrolidine dithiocarbamic acid 97-123 interleukin 1 beta Homo sapiens 0-8 15014040-7 2004 A NF-kappaB inhibitor, pyrrolidine dithiocarbamate, suppressed both MMP-9 expression and invasiveness of IL-1beta-treated GCTM-1 cells. pyrrolidine dithiocarbamic acid 23-50 interleukin 1 beta Homo sapiens 105-113 14566967-6 2003 Pyrrolidine dithiocarbamate (PDTC), a scavenger of reactive oxygen species (ROS) blocked apoptosis induction by CH-11/PSI as well as the enhancement by IL-1beta. pyrrolidine dithiocarbamic acid 0-27 interleukin 1 beta Homo sapiens 152-160 14566967-6 2003 Pyrrolidine dithiocarbamate (PDTC), a scavenger of reactive oxygen species (ROS) blocked apoptosis induction by CH-11/PSI as well as the enhancement by IL-1beta. pyrrolidine dithiocarbamic acid 29-33 interleukin 1 beta Homo sapiens 152-160 12714616-14 2003 The NFkappaB inhibitors pyrrolidinedithiocarbamate (PDTC; 100 microM), caffeic acid phenethyl ester (CAPE; 90 microM), and MG-132 (25 microM), blocked IL-1beta-stimulated expression of hBD-2. pyrrolidine dithiocarbamic acid 24-50 interleukin 1 beta Homo sapiens 151-159 12505195-4 2003 In the present paper we investigated the effect of pharmacological inhibition of NF-kappaB with pyrrolidinedithiocarbamate (PDTC) on IL-1beta-induced IL-8 production by the human intestinal epithelial cell line HT-29. pyrrolidine dithiocarbamic acid 96-122 interleukin 1 beta Homo sapiens 133-141 12505195-4 2003 In the present paper we investigated the effect of pharmacological inhibition of NF-kappaB with pyrrolidinedithiocarbamate (PDTC) on IL-1beta-induced IL-8 production by the human intestinal epithelial cell line HT-29. pyrrolidine dithiocarbamic acid 124-128 interleukin 1 beta Homo sapiens 133-141 12356282-6 2002 Treatment of cells with byakangelicol (50 microM) or pyrrolidine dithiocarbamate (PDTC; 50 microM) partially inhibited IL-1beta-induced degradation of IkappaB-alpha in the cytosol, translocation of p65 NF-kappaB from the cytosol to the nucleus and the NF-kappaB-specific DNA-protein complex formation. pyrrolidine dithiocarbamic acid 53-80 interleukin 1 beta Homo sapiens 119-127 12356282-6 2002 Treatment of cells with byakangelicol (50 microM) or pyrrolidine dithiocarbamate (PDTC; 50 microM) partially inhibited IL-1beta-induced degradation of IkappaB-alpha in the cytosol, translocation of p65 NF-kappaB from the cytosol to the nucleus and the NF-kappaB-specific DNA-protein complex formation. pyrrolidine dithiocarbamic acid 82-86 interleukin 1 beta Homo sapiens 119-127