PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11494409-4 2001 The activation of transcription factor NF-kappaB was apparently required for AMB-induced iNOS mRNA expression, as the latter was abolished by NF-kappaB inhibitors: pyrrolidine dithiocarbamate and MG132. pyrrolidine dithiocarbamic acid 164-191 nitric oxide synthase 2 Rattus norvegicus 89-93 15274191-6 2004 Expression of iNOS mRNA had a 167-fold increase from normal in controls, but was significantly (P < 0.05) reduced to a 63-fold increase in PDTC-treated muscles. pyrrolidine dithiocarbamic acid 142-146 nitric oxide synthase 2 Rattus norvegicus 14-18 14660032-6 2003 Furthermore, pyrrolidine dithiocarbamate markedly reduced the expression of inducible nitric oxide synthase (iNOS) protein and significantly reduced serum levels of nitric oxide. pyrrolidine dithiocarbamic acid 13-40 nitric oxide synthase 2 Rattus norvegicus 76-107 14660032-6 2003 Furthermore, pyrrolidine dithiocarbamate markedly reduced the expression of inducible nitric oxide synthase (iNOS) protein and significantly reduced serum levels of nitric oxide. pyrrolidine dithiocarbamic acid 13-40 nitric oxide synthase 2 Rattus norvegicus 109-113 12509805-3 2003 Cytokine-induced increases in nitrite accumulation (an index of NO production) and iNOS expression were attenuated by inhibition of NF-kappaB with pyrrolidine dithiocarbamate (PDTC). pyrrolidine dithiocarbamic acid 147-174 nitric oxide synthase 2 Rattus norvegicus 83-87 12509805-3 2003 Cytokine-induced increases in nitrite accumulation (an index of NO production) and iNOS expression were attenuated by inhibition of NF-kappaB with pyrrolidine dithiocarbamate (PDTC). pyrrolidine dithiocarbamic acid 176-180 nitric oxide synthase 2 Rattus norvegicus 83-87 9378986-4 1997 Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappa B effective in cellular studies, prevented NF-kappa B activation in vivo and reduced iNOS mRNA expression and the increase in iNOS activity activated by LPS. pyrrolidine dithiocarbamic acid 0-27 nitric oxide synthase 2 Rattus norvegicus 146-150 11093766-5 2000 The NF-kappaB inhibitors pyrrolidine dithiocarbamate and N(alpha)-p-tosyl-L-lysine chloromethyl ketone abrogated LPS- and interferon-gamma-induced increase of nitrite accumulation and L-[(3)H]arginine uptake as well as up-regulation of iNOS and CAT-2B mRNA. pyrrolidine dithiocarbamic acid 25-52 nitric oxide synthase 2 Rattus norvegicus 236-240 9788894-6 1998 .NO production and iNOS protein expression by both macrophages and epithelial cells were blocked by pyrrolidine dithiocarbamate (PDTC), an agent that inhibits activity of nuclear transcription factor kappa B (NF-kappa B). pyrrolidine dithiocarbamic acid 100-127 nitric oxide synthase 2 Rattus norvegicus 19-23 9788894-6 1998 .NO production and iNOS protein expression by both macrophages and epithelial cells were blocked by pyrrolidine dithiocarbamate (PDTC), an agent that inhibits activity of nuclear transcription factor kappa B (NF-kappa B). pyrrolidine dithiocarbamic acid 129-133 nitric oxide synthase 2 Rattus norvegicus 19-23 9464257-4 1998 Inhibition of redox-sensitive signaling mechanisms by the antioxidant pyrrolidine dithiocarbamate (PDTC) blocked NO production, iNOS expression, and NF-kappa B activation elicited by both IgE/DNP-BSA complexes and anti-CD23 F(ab")2, thus suggesting the involvement of NF-kappa B in the signaling pathway leading to the transcriptional activation of iNOS. pyrrolidine dithiocarbamic acid 70-97 nitric oxide synthase 2 Rattus norvegicus 349-353 9464257-4 1998 Inhibition of redox-sensitive signaling mechanisms by the antioxidant pyrrolidine dithiocarbamate (PDTC) blocked NO production, iNOS expression, and NF-kappa B activation elicited by both IgE/DNP-BSA complexes and anti-CD23 F(ab")2, thus suggesting the involvement of NF-kappa B in the signaling pathway leading to the transcriptional activation of iNOS. pyrrolidine dithiocarbamic acid 99-103 nitric oxide synthase 2 Rattus norvegicus 128-132 9464257-4 1998 Inhibition of redox-sensitive signaling mechanisms by the antioxidant pyrrolidine dithiocarbamate (PDTC) blocked NO production, iNOS expression, and NF-kappa B activation elicited by both IgE/DNP-BSA complexes and anti-CD23 F(ab")2, thus suggesting the involvement of NF-kappa B in the signaling pathway leading to the transcriptional activation of iNOS. pyrrolidine dithiocarbamic acid 99-103 nitric oxide synthase 2 Rattus norvegicus 349-353 9400371-4 1997 H-89, dexamethasone, herbimycin, genistein, staurosporine, or pyrrolidine dithiocarbamate (PDTC) attenuated the iNOS induction by LPS. pyrrolidine dithiocarbamic acid 62-89 nitric oxide synthase 2 Rattus norvegicus 112-116 9400371-4 1997 H-89, dexamethasone, herbimycin, genistein, staurosporine, or pyrrolidine dithiocarbamate (PDTC) attenuated the iNOS induction by LPS. pyrrolidine dithiocarbamic acid 91-95 nitric oxide synthase 2 Rattus norvegicus 112-116 11342654-6 2001 Pretreatment with pyrrolidine dithiocarbamate or sulfasalazine attenuated the iNOS-dependent production of NO in the lung and restored the normal up-regulation of alveolar fluid clearance by catecholamines after prolonged hemorrhagic shock. pyrrolidine dithiocarbamic acid 18-45 nitric oxide synthase 2 Rattus norvegicus 78-82 11272138-6 2001 Inhibitors of NF-kappaB activation-the proteasome inhibitor MG-132 and the antioxidant pyrrolidine-dithiocarbamate (PDTC)-prevented poly IC + IFN-gamma-induced iNOS expression and nitric oxide production. pyrrolidine dithiocarbamic acid 87-114 nitric oxide synthase 2 Rattus norvegicus 160-164 11272138-6 2001 Inhibitors of NF-kappaB activation-the proteasome inhibitor MG-132 and the antioxidant pyrrolidine-dithiocarbamate (PDTC)-prevented poly IC + IFN-gamma-induced iNOS expression and nitric oxide production. pyrrolidine dithiocarbamic acid 116-120 nitric oxide synthase 2 Rattus norvegicus 160-164 11530235-6 2001 The oxidant scavenger pyrrolidine dithiocarbamate abolished interleukin 1beta-induced NOS-2 mRNA accumulation and decreased nitric oxide production in a concentration-dependent manner, thus indicating that this antioxidant decreased either the transcription of NOS-2 gene or the stability of NOS-2 mRNA. pyrrolidine dithiocarbamic acid 22-49 nitric oxide synthase 2 Rattus norvegicus 86-91 11530235-6 2001 The oxidant scavenger pyrrolidine dithiocarbamate abolished interleukin 1beta-induced NOS-2 mRNA accumulation and decreased nitric oxide production in a concentration-dependent manner, thus indicating that this antioxidant decreased either the transcription of NOS-2 gene or the stability of NOS-2 mRNA. pyrrolidine dithiocarbamic acid 22-49 nitric oxide synthase 2 Rattus norvegicus 261-266 11530235-6 2001 The oxidant scavenger pyrrolidine dithiocarbamate abolished interleukin 1beta-induced NOS-2 mRNA accumulation and decreased nitric oxide production in a concentration-dependent manner, thus indicating that this antioxidant decreased either the transcription of NOS-2 gene or the stability of NOS-2 mRNA. pyrrolidine dithiocarbamic acid 22-49 nitric oxide synthase 2 Rattus norvegicus 261-266 10800947-8 2000 Glutamate-dependent iNOS expression was concentration-dependent and was blocked by EGTA and by the inhibitors of nuclear factor kappaB (NF-kappaB) activation pyrrolidine dithiocarbamate and MG132. pyrrolidine dithiocarbamic acid 158-185 nitric oxide synthase 2 Rattus norvegicus 20-24 9446561-9 1998 Inhibition of ceramide and LPS-mediated induction of iNOS by antioxidant inhibitors of NF-kappaB (N-acetylcysteine and pyrrolidine dithiocarbamate) suggest that the stimulatory effect of ceramide on the induction of iNOS is due to the stimulation of NF-kappaB activation and that cellular redox plays a role in the activation of NF-kappaB and induction of iNOS. pyrrolidine dithiocarbamic acid 119-146 nitric oxide synthase 2 Rattus norvegicus 53-57 9464257-4 1998 Inhibition of redox-sensitive signaling mechanisms by the antioxidant pyrrolidine dithiocarbamate (PDTC) blocked NO production, iNOS expression, and NF-kappa B activation elicited by both IgE/DNP-BSA complexes and anti-CD23 F(ab")2, thus suggesting the involvement of NF-kappa B in the signaling pathway leading to the transcriptional activation of iNOS. pyrrolidine dithiocarbamic acid 70-97 nitric oxide synthase 2 Rattus norvegicus 128-132 9378986-4 1997 Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappa B effective in cellular studies, prevented NF-kappa B activation in vivo and reduced iNOS mRNA expression and the increase in iNOS activity activated by LPS. pyrrolidine dithiocarbamic acid 0-27 nitric oxide synthase 2 Rattus norvegicus 187-191 9378986-4 1997 Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappa B effective in cellular studies, prevented NF-kappa B activation in vivo and reduced iNOS mRNA expression and the increase in iNOS activity activated by LPS. pyrrolidine dithiocarbamic acid 29-33 nitric oxide synthase 2 Rattus norvegicus 146-150 9378986-4 1997 Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappa B effective in cellular studies, prevented NF-kappa B activation in vivo and reduced iNOS mRNA expression and the increase in iNOS activity activated by LPS. pyrrolidine dithiocarbamic acid 29-33 nitric oxide synthase 2 Rattus norvegicus 187-191 8662662-5 1996 The oxidant scavenger, pyrrolidine dithiocarbamate (PDTC), inhibited iNOS expression at the transcriptional level, since PDTC abolished iNOS mRNA accumulation. pyrrolidine dithiocarbamic acid 23-50 nitric oxide synthase 2 Rattus norvegicus 69-73 9218608-4 1997 However, the expression of iNOS and CINC-1 mRNA induced by IC showed a different temporal pattern and a different sensitivity to both the antioxidant agent pyrrolidine dithiocarbamate (PDTC) and modulation by NO itself. pyrrolidine dithiocarbamic acid 156-183 nitric oxide synthase 2 Rattus norvegicus 27-31 9218608-4 1997 However, the expression of iNOS and CINC-1 mRNA induced by IC showed a different temporal pattern and a different sensitivity to both the antioxidant agent pyrrolidine dithiocarbamate (PDTC) and modulation by NO itself. pyrrolidine dithiocarbamic acid 185-189 nitric oxide synthase 2 Rattus norvegicus 27-31 9144512-17 1997 Moreover, pyrrolidine dithiocarbamate supplementation, which down-regulates iNOS expression and blocks superoxide dismutase activity, initiates apoptosis. pyrrolidine dithiocarbamic acid 10-37 nitric oxide synthase 2 Rattus norvegicus 76-80 9235225-5 1997 Low environmental pH-induced iNOS gene expression involved the activation of nuclear factor-kappa B (NF-kappa B) transcription factor since [1] exposure of macrophages to low environmental pH increased NF-kappa B binding activity in the nucleus, and [2] treatment of macrophages with pyrrolidine dithiocarbamate or n-acetyl-leucinyl-norleucinal, two drugs preventing NF-kappa B translocation to the nucleus, canceled low pH-induced nitrite accumulation. pyrrolidine dithiocarbamic acid 284-311 nitric oxide synthase 2 Rattus norvegicus 29-33 8939960-5 1996 Inhibition of NF-kappaB activation with pyrrolidine dithiocarbamate eliminated the expression of iNOS in hepatocytes stimulated with LPS, TPP, or PDBu. pyrrolidine dithiocarbamic acid 40-67 nitric oxide synthase 2 Rattus norvegicus 97-101 8903404-9 1996 The addition of the nuclear factor kappaB (NF-kappaB) inhibitor pyrrolidine dithiocarbamate also inhibited NOS2 expression, suggesting a role for NF-kappaB in the cytokine induction of NOS2 in hepatocytes. pyrrolidine dithiocarbamic acid 64-91 nitric oxide synthase 2 Rattus norvegicus 107-111 8903404-9 1996 The addition of the nuclear factor kappaB (NF-kappaB) inhibitor pyrrolidine dithiocarbamate also inhibited NOS2 expression, suggesting a role for NF-kappaB in the cytokine induction of NOS2 in hepatocytes. pyrrolidine dithiocarbamic acid 64-91 nitric oxide synthase 2 Rattus norvegicus 185-189 8760147-13 1996 IL-1 beta-mediated increases in steady-state iNOS mRNA were sensitive to pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappa B activation. pyrrolidine dithiocarbamic acid 73-100 nitric oxide synthase 2 Rattus norvegicus 45-49 8672550-6 1996 Pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of NF-kappa B activation, inhibited the NTS-induced increase of glomerular NF-kappa B DNA-binding activity, followed by the inhibition of mRNA expression of IL-1 beta, MCP-1, ICAM-1 and iNOS, which are known to be regulated by NF-kappa B. PDTC also prevented urinary protein excretion which is a pathophysiological parameter for glomerulonephritis. pyrrolidine dithiocarbamic acid 0-27 nitric oxide synthase 2 Rattus norvegicus 241-245 8672550-6 1996 Pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of NF-kappa B activation, inhibited the NTS-induced increase of glomerular NF-kappa B DNA-binding activity, followed by the inhibition of mRNA expression of IL-1 beta, MCP-1, ICAM-1 and iNOS, which are known to be regulated by NF-kappa B. PDTC also prevented urinary protein excretion which is a pathophysiological parameter for glomerulonephritis. pyrrolidine dithiocarbamic acid 29-33 nitric oxide synthase 2 Rattus norvegicus 241-245 8662662-5 1996 The oxidant scavenger, pyrrolidine dithiocarbamate (PDTC), inhibited iNOS expression at the transcriptional level, since PDTC abolished iNOS mRNA accumulation. pyrrolidine dithiocarbamic acid 23-50 nitric oxide synthase 2 Rattus norvegicus 136-140 8662662-5 1996 The oxidant scavenger, pyrrolidine dithiocarbamate (PDTC), inhibited iNOS expression at the transcriptional level, since PDTC abolished iNOS mRNA accumulation. pyrrolidine dithiocarbamic acid 52-56 nitric oxide synthase 2 Rattus norvegicus 69-73 8662662-5 1996 The oxidant scavenger, pyrrolidine dithiocarbamate (PDTC), inhibited iNOS expression at the transcriptional level, since PDTC abolished iNOS mRNA accumulation. pyrrolidine dithiocarbamic acid 52-56 nitric oxide synthase 2 Rattus norvegicus 136-140 21208093-0 2010 Pyrrolidine dithiocarbamate modulates HSP70, iNOS, and apoptosis during hemorrhagic shock resuscitation in rats. pyrrolidine dithiocarbamic acid 0-27 nitric oxide synthase 2 Rattus norvegicus 45-49 7588208-4 1995 Inhibitors of NFkappaB, diethyldithiocarbamate, pyrrolidine dithiocarbamate, and N-acetyl cysteine prevent IL-1-induced iNOS expression at the level of messenger RNA, protein, and nitrite generation. pyrrolidine dithiocarbamic acid 48-75 nitric oxide synthase 2 Rattus norvegicus 120-124 7588208-8 1995 IL-1-induced translocation of NF kappa B was blocked by 100 microns 100 microM diethyldithiocarbamate or 100 microM pyrrolidine dithiocarbamate, further establishing a critical role for NF kappa B in the induction of iNOS by IL-1 in rat pancreatic beta-cells. pyrrolidine dithiocarbamic acid 116-143 nitric oxide synthase 2 Rattus norvegicus 217-221 34446210-6 2021 Pyrrolidine dithiocarbamate (PDTC), NF-kappaB inhibitor, did not alter CYP2E1 but mitigated free radical generation, SOD activity, LPO, nitrite content, iNOS activity/expression and levels of pro-inflammatory cytokines (tumor necrosis factor-alpha, interleukine-1beta and interleukine-4). pyrrolidine dithiocarbamic acid 0-27 nitric oxide synthase 2 Rattus norvegicus 153-157 34446210-6 2021 Pyrrolidine dithiocarbamate (PDTC), NF-kappaB inhibitor, did not alter CYP2E1 but mitigated free radical generation, SOD activity, LPO, nitrite content, iNOS activity/expression and levels of pro-inflammatory cytokines (tumor necrosis factor-alpha, interleukine-1beta and interleukine-4). pyrrolidine dithiocarbamic acid 29-33 nitric oxide synthase 2 Rattus norvegicus 153-157 32440769-0 2020 Pyrrolidine dithiocarbamate reduces alloxan-induced kidney damage by decreasing nox4, inducible nitric oxide synthase, and metalloproteinase-2. pyrrolidine dithiocarbamic acid 0-27 nitric oxide synthase 2 Rattus norvegicus 86-117 30595795-0 2018 Pyrrolidine Dithiocarbamate (PDTC) Inhibits DON-Induced Mitochondrial Dysfunction and Apoptosis via the NF-kappaB/iNOS Pathway. pyrrolidine dithiocarbamic acid 0-27 nitric oxide synthase 2 Rattus norvegicus 114-118 30595795-0 2018 Pyrrolidine Dithiocarbamate (PDTC) Inhibits DON-Induced Mitochondrial Dysfunction and Apoptosis via the NF-kappaB/iNOS Pathway. pyrrolidine dithiocarbamic acid 29-33 nitric oxide synthase 2 Rattus norvegicus 114-118 22004609-7 2011 Treatment of cells with pyrrolidine dithiocarbamate (PDTC, an NF-kappaB inhibitor) inhibited thrombin-induced iNOS expression in a concentration-dependent manner. pyrrolidine dithiocarbamic acid 24-51 nitric oxide synthase 2 Rattus norvegicus 110-114 22004609-7 2011 Treatment of cells with pyrrolidine dithiocarbamate (PDTC, an NF-kappaB inhibitor) inhibited thrombin-induced iNOS expression in a concentration-dependent manner. pyrrolidine dithiocarbamic acid 53-57 nitric oxide synthase 2 Rattus norvegicus 110-114 17991490-8 2007 Benzo(a)pyrene-augmented iNOS expression and activity in PMNs were significantly reverse by felodipine, genistein, or PDTC. pyrrolidine dithiocarbamic acid 118-122 nitric oxide synthase 2 Rattus norvegicus 25-29