PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34913726-3	2022	Apabetalone (APA), a selective inhibitor of bromodomain (BRD) and extra-terminal (BET) proteins, prevents BRD4 interactions with chromatin thus modulating transcriptional programs in different organs.	apabetalone	0-11	bromodomain containing 4	Homo sapiens	106-110	
34913726-3	2022	Apabetalone (APA), a selective inhibitor of bromodomain (BRD) and extra-terminal (BET) proteins, prevents BRD4 interactions with chromatin thus modulating transcriptional programs in different organs.	apabetalone	13-16	bromodomain containing 4	Homo sapiens	106-110	
32821285-7	2020	Mechanistically, apabetalone reduces the cytokine-driven increase in BRD4 BET occupancy at the CRP promoter, confirming that transcription of CRP is BET-dependent.	apabetalone	17-28	bromodomain containing 4	Homo sapiens	69-73	
31257080-0	2019	Design, synthesis and biological evaluation of hypolipidemic compounds based on BRD4 inhibitor RVX-208.	apabetalone	95-102	bromodomain containing 4	Homo sapiens	80-84	
31257080-2	2019	In this study, we introduced the pharmacophore of fibrates to a BRD4 inhibitor, RVX-208, to design dual-active hypolipidemic compounds, and found that some of new analogues showed favorable hypolipidemic activities.	apabetalone	80-87	bromodomain containing 4	Homo sapiens	64-68	
31300040-7	2019	BRD4 abundance on inflammatory and adhesion gene promoters and enhancers was reduced by apabetalone.	apabetalone	88-99	bromodomain containing 4	Homo sapiens	0-4	
30476723-9	2019	Apabetalone reduced the size of BRD4-rich enhancers, consistent with disrupting BRD4 association with chromatin.	apabetalone	0-11	bromodomain containing 4	Homo sapiens	32-36	
30476723-9	2019	Apabetalone reduced the size of BRD4-rich enhancers, consistent with disrupting BRD4 association with chromatin.	apabetalone	0-11	bromodomain containing 4	Homo sapiens	80-84	
30476723-11	2019	Apabetalone reduced levels of BRD4 on many of these enhancers, which correlated with decreased expression of the associated gene.	apabetalone	0-11	bromodomain containing 4	Homo sapiens	30-34