PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2344458-2 1990 In this system cytochrome P-450 effectuates a steady-state demethylation of dimethylaniline and hydroxylation of aniline. aniline 84-91 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 15-31 1344831-4 1992 Omeprazole interacts with the cytochrome P-450 system in the liver: inhibition of several liver mono-oxygenases activities (inhibitory effect on diazepam, phenytoin and R-warfarin metabolism with prolonged elimination); induction of P-450 (IA1 and IA2) enzymes that may potentiate the hepatotoxic effect of phenacetin and acetaminophen or increase the tumorigenic effect of chemical carcinogens (polycyclic aromatic hydrocarbons, arylamines, aflatoxin). aniline 430-440 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 30-46 2322954-0 1990 The role of hydrophobicity and electronic factors in regulating alcohol inhibition of cytochrome P-450-mediated aniline hydroxylation. aniline 112-119 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 86-102 2322954-1 1990 The role of hydrophobicity and electronic factors in regulating alcohol inhibition of cytochrome P-450-mediated aniline p-hydroxylation has been investigated by the formulation of quantitative structure-activity relationships. aniline 112-119 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 86-102 2983185-2 1985 Reaction thermodynamics have been calculated for an oxene model for cytochrome P-450 oxidations of four related arylamines: aniline, p-hydroxyaniline, acetanilide, and acetaminophen, by both radical and nonradical mechanisms, using a semiempirical molecular orbital method (modified neglect of differential overlap). aniline 112-122 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 68-84 3420813-1 1988 Content and catalytic activity of cytochrome P-450 were studied using amidopyrine as a substrate of the I type and aniline as a substrate of the II type. aniline 115-122 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 34-50 3337722-2 1988 These compounds inhibit oxidation and binding of the substrates of cytochrome P-450 (aminopyrine and aniline), inhibition being of a competitive character. aniline 101-108 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 67-83 3621372-0 1987 Quantitative structure-activity relationships in a series of alcohols exhibiting inhibition of cytochrome P-450-mediated aniline hydroxylation. aniline 121-128 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 95-111 4063403-1 1985 It has been shown that sodium azide, a catalase inhibitor, accelerates the inactivation of cytochrome P-450 in reactions of hydroxylation of type I substrates, e.g., dimethylaniline (DMA), aminopyrine (AP), benzphetamine (BPh), p-nitroanisole (p-Na) and type II substrates--aniline (AN). aniline 272-281 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 91-107 4016117-3 1985 The compounds inhibit oxidation and binding of cytochrome P-450 substrates of type I (naphthalene, aminopyrine) and of type II (aniline). aniline 128-135 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 47-63 2983185-2 1985 Reaction thermodynamics have been calculated for an oxene model for cytochrome P-450 oxidations of four related arylamines: aniline, p-hydroxyaniline, acetanilide, and acetaminophen, by both radical and nonradical mechanisms, using a semiempirical molecular orbital method (modified neglect of differential overlap). aniline 124-131 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 68-84 7285242-8 1981 On the contrary, the absorbance magnitude between peak and trough in the aniline- or alcohol-induced difference spectrum of microsomes was enhanced by decreasing the pH, indicating easy complex formation of type II and reverse type I compounds with cytochrome P-450 in the acid rather than the alkaline region. aniline 73-80 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 249-265 2983784-5 1985 The alkylating radical substrate analogs covalently bound to microsomal cytochrome P-450 in the vicinity of the active center, resulting in the inhibition of oxidation of type I and II substrates (e. g., aniline and naphthalene). aniline 204-211 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 72-88 6696448-4 1984 Such a cytochrome b5-induced structural alteration of the reconstituted enzyme system is accompanied by an increase in affinity of 4-chloroaniline for cytochrome P-450, as measured in terms of cumene hydroperoxide-supported N-oxidation of the arylamine; the maximum velocity of the catalytic process remains unchanged. aniline 243-252 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 151-167 6661451-0 1983 [Comparative inhibitory analysis of aniline hydroxylation by cytochrome P-450 in NADPH-, hydroperoxide cumyl- and H2O2-dependent systems]. aniline 36-43 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 61-77 6888166-2 1983 The results indicate that the in vitro interaction of hexobarbital and SKF-525 A (type I binding compounds) with microsomal cytochrome p-450 inhibits the peroxidase activity while the in vitro interaction of aniline (type II binding compound) only slightly affect the peroxidase activity. aniline 208-215 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 124-140 6272881-3 1981 In case of p-hydroxylation of aniline the inhibiting effect of the Cu-tyrosine complex is much more pronounced than its inactivating effect on cytochrome P-450. aniline 30-37 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 143-159 6272881-6 1981 In a soluble system containing isolated cytochrome P-450 and cumole hydroperoxide only the aniline p-hydroxylation reaction was found sensitive to the effect of superoxide dismutase. aniline 91-98 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 40-56 6285925-0 1982 Aniline is hydroxylated by the cytochrome P-450-dependent hydroxyl radical-mediated oxygenation mechanism. aniline 0-7 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 31-47 7370330-1 1980 Thermal inactivation of cytochrome P-450 in different states (microsomes, highly purified and immobilized), characterized by the loss of catalytic activity in cumene hydroperoxide--dependent aniline hydroxylation has been studied in the temperature range 40-58 degrees C. The process of thermoinactivation is characterized by the first order rate constants. aniline 191-198 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 24-40 7297957-1 1981 Hemoglobin and cytochrome P-450 have in common heme structure (i.e. protoporphyrin (IX), binding ability to molecular oxygen or carbon monoxide and enzyme-like activity (i.e. aniline hydroxylation; J.B.C. aniline 175-182 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 15-31 519812-0 1979 A model system of cytochrome P-450: hydroxylation of aniline by iron- or hemin-thiol compound systems. aniline 53-60 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 18-34 6086112-0 1980 [Effect of phospholipids on the activity of highly-purified liver microsome cytochrome P-450 in a reaction of aniline and naphthalene hydroxylation by hydroperoxides]. aniline 110-117 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 76-92 517003-4 1979 Liposome-bound cytochrome P-450 has a higher dimethylaniline, aniline and p-nitroanisole hydroxylase activity than its soluble form. aniline 53-60 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 15-31 722999-0 1978 Glutathione depletion by aniline analogs in vitro associated with liver microsomal cytochrome P-450. aniline 25-32 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 83-99 722999-1 1978 Enzymic depletion of glutathione (GSH) in vitro by aniline analogs was mostly dependent on the cytochrome P-450 level in liver microsomes. aniline 51-58 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 95-111 173534-9 1975 A second effect of aniline, a type II ligand of cytochrome P-450, was to remove the g = 6 signal, suggesting that it also interacts with cytochrome P-420. aniline 19-26 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 48-64 208787-0 1978 A model of cytochrome P-450; optical and EPR properties of a thiol-containing peptide-hemin system and its activity of aniline hydroxylation. aniline 119-126 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 11-27 12746-5 1976 In the presence of 0.03-0.09% sodium deoxycholate the rate-limiting factor in p-hydroxylation of aniline is the content of cytochrome P-450. aniline 97-104 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 123-139 956135-2 1976 During reduction of aniline and azide complexes with cytochrome P-450, an intermediate spectrum developed in the fast phase and changed to that of the reduced form in the slow phase. aniline 20-27 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 53-69 956135-7 1976 These results indicate that reduction of the aniline and azide complexes of cytochrome P-450 involves two steps: first reduction of cytochrome P-450 and then some changes in reduced state. aniline 45-52 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 76-92 956135-7 1976 These results indicate that reduction of the aniline and azide complexes of cytochrome P-450 involves two steps: first reduction of cytochrome P-450 and then some changes in reduced state. aniline 45-52 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 132-148 956135-8 1976 The aniline and cyanide difference spectra of reduced cytochrome P-450 showed peaks at 423 nm and 429 nm, respectively, while that of azide had a peak at 445 nm and a trough at 404 nm. aniline 4-11 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 54-70 1201750-3 1975 On the basis of binding studies with ethyl isocyanide, degradation of cytochrome P-450 to P-420, redox potential, aniline binding, and relative rates of reduction by NADPH and NADH, it is suggested that the cytochrome P-450 system is analogous to that mammalian microsomes. aniline 114-121 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 207-223 1131251-0 1975 Purification of cytochrome P-450 from bovin adrenocortical mitochondria by an "aniline-sepharose" and the properties. aniline 79-86 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 16-32 14744142-1 2004 Cytochrome P450 (P450) 1A2 is the major enzyme involved in the metabolism of 2-amino-3,5-dimethylimidazo[4,5-f]quinoline (MeIQ) and other heterocyclic arylamines and their bioactivation to mutagens. aniline 151-161 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-26 10819168-0 2000 The use of "electronic nose" sensor responses to predict the inhibition activity of alcohols on the cytochrome P-450 catalyzed p-hydroxylation of aniline. aniline 146-153 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 100-116 10819168-1 2000 A quantitative structure activity relationship (QSAR) has been formulated to describe the inhibitory action of a series of alcohols on the cytochrome P-450 catalyzed p-hydroxylation of aniline. aniline 185-192 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 139-155 9820175-5 1998 Specific substrates of CYP included testosterone (catalysed by CYP3A4), paclitaxel (CYP2C8), 7-ethoxyresorufin (CYP1A1, CYP1A2), coumarin (CYP2A6), aniline (CYP2E1) and (+/-)-bufuralol (CYP2D6). aniline 148-155 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 23-26