PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16574906-4 2006 We show in single-cell measurements using the Ca2+ indicator fura-2 acetoxy methylester (fura-2 AM) and the nitric oxide (NO) indicator 4,5-diaminofluorescein diacetate that application of endostatin (ES) (5 pmol/L, 100 ng/mL) induced Ca2+ spikes and an increase of NO production in human and murine endothelial cells. 4,5-diaminofluorescein diacetate 136-168 collagen type XVIII alpha 1 chain Homo sapiens 189-199