PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29680917-3	2018	The results showed that production of TNF-alpha, IL-1beta, IL-6, and NO and TNF-alpha, IL-1beta, IL-6, and iNOS mRNA were inhibited by scutellarin, which was independent of cytotoxicity as assessed by a CCK8 assay.	scutellarin	135-146	interleukin 1 beta	Mus musculus	49-57	
29680917-3	2018	The results showed that production of TNF-alpha, IL-1beta, IL-6, and NO and TNF-alpha, IL-1beta, IL-6, and iNOS mRNA were inhibited by scutellarin, which was independent of cytotoxicity as assessed by a CCK8 assay.	scutellarin	135-146	interleukin 1 beta	Mus musculus	87-95	
29375379-7	2017	The results showed that scutellarin dose-dependently reduced caspase-1 activation and decreased mature interleukin-1beta (IL-1beta) release in lipopolysaccharide (LPS)-primed macrophages upon ATP or nigericin stimulation, indicating that scutellarin inhibited NLRP3 inflammasome activation in macrophages.	scutellarin	24-35	interleukin 1 beta	Mus musculus	103-120	
29375379-12	2017	As NLRP3-dependent release of IL-1beta has a critical role in sepsis, the in vivo activity of scutellarin was assayed in a mouse model of bacterial sepsis, which was established by intraperitoneally injection of a lethal dose of viable Escherichia coli.	scutellarin	94-105	interleukin 1 beta	Mus musculus	30-38	
29375379-14	2017	In line with this, scutellarin treatment significantly reduced serum IL-1beta levels and attenuated the infiltration of inflammatory cells in the liver of E. coli-infected mice.	scutellarin	19-30	interleukin 1 beta	Mus musculus	69-77	
29375379-7	2017	The results showed that scutellarin dose-dependently reduced caspase-1 activation and decreased mature interleukin-1beta (IL-1beta) release in lipopolysaccharide (LPS)-primed macrophages upon ATP or nigericin stimulation, indicating that scutellarin inhibited NLRP3 inflammasome activation in macrophages.	scutellarin	24-35	interleukin 1 beta	Mus musculus	122-130	
28849116-8	2017	The present study demonstrated that scutellarin prevented CIA, and inhibited the expression of inflammation factors, IL-1beta, IL-6 and TNF-alpha.	scutellarin	36-47	interleukin 1 beta	Mus musculus	117-125