PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28249594-4 2017 In this study, we formulated and characterized a novel intestinal target nanoparticle carrier based on amphiphilic chitosan derivatives (Chit-DC-VB12) loaded with scutellarin to enhance its bioavailability and then evaluated its therapeutic effect in experimental diabetic retinopathy model. scutellarin 163-174 chitinase 1 Homo sapiens 137-141 28249594-10 2017 Bioavailability studies were performed in Sprague-Dawley rats, which present the area under the curve of scutellarin of Chit-DC-VB12-Scu was two to threefolds greater than that of free scutellarin alone. scutellarin 105-116 chitinase 1 Homo sapiens 120-124 28249594-13 2017 In conclusion, the Chit-DC-VB12 nanoparticles enhanced scutellarin oral delivery efficacy and exhibited potential as small intestinal target promising nano-carriers for treatment of type II diabetes induced-retinopathy. scutellarin 55-66 chitinase 1 Homo sapiens 19-23