PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22882835-0 2012 Evaluation of imidazole-based compounds as heme oxygenase-1 inhibitors. imidazole 14-23 heme oxygenase 1 Homo sapiens 43-59 23867390-2 2013 Some of these compounds were found to be good inhibitors of HO-1, in particular those carrying an imidazole moiety as azolyl group and a 3-bromo or 4-iodophenyl as aryl moiety. imidazole 98-107 heme oxygenase 1 Homo sapiens 60-64 23867390-0 2013 Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties. imidazole 48-57 heme oxygenase 1 Homo sapiens 80-96 23867390-0 2013 Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties. imidazole 48-57 heme oxygenase 1 Homo sapiens 98-102 23867390-1 2013 A novel series of aryloxyalkyl derivatives of imidazole and 1,2,4-triazole, 17-31, was designed and synthesized as inhibitors of heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2). imidazole 46-55 heme oxygenase 1 Homo sapiens 129-145 23867390-1 2013 A novel series of aryloxyalkyl derivatives of imidazole and 1,2,4-triazole, 17-31, was designed and synthesized as inhibitors of heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2). imidazole 46-55 heme oxygenase 1 Homo sapiens 147-151 18798608-0 2008 X-ray crystal structure of human heme oxygenase-1 in complex with 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone: a common binding mode for imidazole-based heme oxygenase-1 inhibitors. imidazole 141-150 heme oxygenase 1 Homo sapiens 33-49 19212657-10 2009 By supplementing imidazole, the HO-1 activity was restored approximately 90% to its normal level. imidazole 17-26 heme oxygenase 1 Homo sapiens 32-36 19122175-9 2009 Similarly to inhibition of prostacyclin biosynthesis or activity, the novel imidazole-based HO-1 inhibitor QC15 reversed TNF-alpha reduction by LSS. imidazole 76-85 heme oxygenase 1 Homo sapiens 92-96 18798608-0 2008 X-ray crystal structure of human heme oxygenase-1 in complex with 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone: a common binding mode for imidazole-based heme oxygenase-1 inhibitors. imidazole 141-150 heme oxygenase 1 Homo sapiens 157-173 17761847-1 2007 To enhance our understanding of the physiological roles of heme oxygenase (HO) isozymes, HO-1 (inducible) and HO-2 (constitutive), we developed novel imidazole-based HO inhibitors. imidazole 150-159 heme oxygenase 1 Homo sapiens 89-93 34710668-0 2021 Growing the molecular architecture of imidazole-like ligands in HO-1 complexes. imidazole 38-47 heme oxygenase 1 Homo sapiens 64-68 34959690-0 2021 From Far West to East: Joining the Molecular Architecture of Imidazole-like Ligands in HO-1 Complexes. imidazole 61-70 heme oxygenase 1 Homo sapiens 87-91 35292342-0 2022 Preliminary studies of an imidazole-based alcohol derivative for imaging of Heme oxygenase 1. imidazole 26-35 heme oxygenase 1 Homo sapiens 76-92 34241977-0 2021 Computational Designing and Prediction of ADMET Properties of Four Novel Imidazole-Based Drug Candidates Inhibiting Heme Oxygenase-1 Causing Cancers. imidazole 73-82 heme oxygenase 1 Homo sapiens 116-132 34241977-2 2021 The inhibition of HO-1 through imidazole-based drugs, which is non-competitive with heme, is a focus of anticancer drug research. imidazole 31-40 heme oxygenase 1 Homo sapiens 18-22 35292342-4 2022 We report herein the synthesis and characterization of a 11C-labeled imidazole-based alcohol derivative ((11C)QC-33) for imaging of HO-1 in the brain. imidazole 69-78 heme oxygenase 1 Homo sapiens 132-136 31137785-7 2019 The activity of HO-1 was inhibited using a selective imidazole-based inhibitor; genes associated with antioxidant systems and cell death were evaluated by qRT-PCR. imidazole 53-62 heme oxygenase 1 Homo sapiens 16-20 33646477-0 2021 East to West not North-West: Structure-Based Mechanistic Resolution of 8-Hydroxyl Replacement and Resulting Effects on the Activities of Imidazole-Based Heme Oxygenase-1 Inhibitors. imidazole 137-146 heme oxygenase 1 Homo sapiens 153-169 33646477-6 2021 Findings revealed favorable binding for the bromobenzene and imidazole substituents of Cpd1 at the western and eastern regions of the HO-1 active domain. imidazole 61-70 heme oxygenase 1 Homo sapiens 134-138 32168943-1 2020 In this paper, a novel series of imidazole-based heme oxygenase-1 (HO-1) inhibitors is reported. imidazole 33-42 heme oxygenase 1 Homo sapiens 49-65 32168943-1 2020 In this paper, a novel series of imidazole-based heme oxygenase-1 (HO-1) inhibitors is reported. imidazole 33-42 heme oxygenase 1 Homo sapiens 67-71 30759842-0 2019 Fourfold Filtered Statistical/Computational Approach for the Identification of Imidazole Compounds as HO-1 Inhibitors from Natural Products. imidazole 79-88 heme oxygenase 1 Homo sapiens 102-106 30759842-3 2019 Imidazole scaffold is normally present in most of the classical HO-1 inhibitors and seems indispensable to the inhibitory activity due to its strong interaction with the Fe(II) of the heme group. imidazole 0-9 heme oxygenase 1 Homo sapiens 64-68 30759842-6 2019 Different imidazole-based compounds were suggested by our methodology to be potentially active in inhibiting the HO-1, and the results have been rationalized by the bioactivity of the filtered molecules reported in the literature. imidazole 10-19 heme oxygenase 1 Homo sapiens 113-117 29454190-0 2018 Potholing of the hydrophobic heme oxygenase-1 western region for the search of potent and selective imidazole-based inhibitors. imidazole 100-109 heme oxygenase 1 Homo sapiens 29-45 30261468-4 2018 With this in mind, in this study, we designed and synthesized the first series of hybrid compounds obtained by combining the structures of IM, as BCR-ABL inhibitor, with imidazole-based HO-1 inhibitors. imidazole 170-179 heme oxygenase 1 Homo sapiens 186-190 29783634-0 2018 Novel Structural Insight into Inhibitors of Heme Oxygenase-1 (HO-1) by New Imidazole-Based Compounds: Biochemical and In Vitro Anticancer Activity Evaluation. imidazole 75-84 heme oxygenase 1 Homo sapiens 44-60 29783634-0 2018 Novel Structural Insight into Inhibitors of Heme Oxygenase-1 (HO-1) by New Imidazole-Based Compounds: Biochemical and In Vitro Anticancer Activity Evaluation. imidazole 75-84 heme oxygenase 1 Homo sapiens 62-66 29783634-1 2018 In this paper, the design, synthesis, and molecular modeling of a new azole-based HO-1 inhibitors was reported, using compound 1 as a lead compound, in which an imidazole moiety is linked to a hydrophobic group by means of an ethanolic spacer. imidazole 161-170 heme oxygenase 1 Homo sapiens 82-86 26208625-0 2015 How does binding of imidazole-based inhibitors to heme oxygenase-1 influence their conformation? imidazole 20-29 heme oxygenase 1 Homo sapiens 50-66 26208625-3 2015 Imidazole-based analogues show effective and selective inhibitory potency of HO-1. imidazole 0-9 heme oxygenase 1 Homo sapiens 77-81 26208625-6 2015 Molecular docking of imidazole-based analogues in the active site of HO-1 is in good agreement with the experimental structures. imidazole 21-30 heme oxygenase 1 Homo sapiens 69-73 25874340-0 2015 Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines. imidazole 6-15 heme oxygenase 1 Homo sapiens 31-47 25874340-0 2015 Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines. imidazole 6-15 heme oxygenase 1 Homo sapiens 49-53 25874340-2 2015 In this work, novel imidazole derivatives were designed and synthesized as inhibitors of heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2). imidazole 20-29 heme oxygenase 1 Homo sapiens 89-105 25874340-2 2015 In this work, novel imidazole derivatives were designed and synthesized as inhibitors of heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2). imidazole 20-29 heme oxygenase 1 Homo sapiens 107-111