PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1334809-7 1992 In apparent agreement with this, Mn2+ influx promoted by TG and tBuBHQ, or by preincubation of cells in Ca(2+)-free medium, was inhibited by the imidazole antimycotics, econazole and miconazole, which inhibit cytochrome P-450 activity. imidazole 145-154 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 209-225 1951574-7 1991 Most of the imidazole and triazole derivatives are highly potent and selective inhibitors of the cytochrome P-450-dependent 14 alpha-demethylation of lanosterol (P-45014DM). imidazole 12-21 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 97-113 2238705-8 1990 Type II binding is seen with inhibitors of mammalian cytochrome P-450 such as metyrapone, and with the imidazole antifungal agents such as clotrimazole. imidazole 103-112 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 53-69 2231265-6 1990 Although the patterns of the inhibitory actions and the interaction of either imidazole drugs with cytochrome P-450 as 17 alpha-hydroxylase and C17,20-lyase were similar to those of KCZ, the inhibitory potencies and affinities for the cytochrome P-450 system decreased in the order of KCZ greater than MCZ greater than OZA greater than M-2 greater than M-1 greater than CIM. imidazole 78-87 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 99-115 2231265-8 1990 These results indicate that either imidazole drugs tested could inhibit a cytochrome P-450 enzyme C17,20-lyase mainly in testicular microsomes, and suggest that MCZ, a potent inhibitor subsequent to KCZ, induces a slight alteration in the testosterone biosynthesis in its clinical use. imidazole 35-44 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 74-90 3404442-7 1988 Imidazole was used because it is a potent inducer of cytochrome P-450 isozyme 3a which is also induced by ethanol. imidazole 0-9 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 53-69 2550511-2 1989 This compound is an imidazole derivative, and therefore, its possible effect on cytochrome P-450-dependent enzyme activities in the adrenal gland was evaluated. imidazole 20-29 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 80-96 2634093-0 1989 Adverse reactions of imidazole antifungal agents: computer graphic studies of cytochrome P-450 interactions. imidazole 21-30 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 78-94 3404442-11 1988 Antibodies to cytochrome P-450 3a inhibited halothane metabolism by 90% in microsomes from imidazole-pretreated rabbits, suggesting that isozyme 3a catalyzes halothane metabolism in imidazole-pretreated rabbits. imidazole 91-100 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 14-30 3404442-11 1988 Antibodies to cytochrome P-450 3a inhibited halothane metabolism by 90% in microsomes from imidazole-pretreated rabbits, suggesting that isozyme 3a catalyzes halothane metabolism in imidazole-pretreated rabbits. imidazole 182-191 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 14-30 3036162-1 1987 Ketoconazole, an imidazole derivative, is a member of a class of metabolic inhibitors acting specifically at cytochrome-P450 mediated reactions. imidazole 17-26 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 109-124 2990136-6 1985 This blockade is due to the interaction of the imidazole structure with the cytochrome p-450. imidazole 47-56 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 76-92 193841-0 1977 Imidazole, the ligand trans to mercaptide in ferric cytochrome P-450. imidazole 0-9 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 52-68 22145115-13 2011 1-Substituted imidazoles bind to cytochrome P-450 with a very high affinity but substitution in the other position of the imidazole decreases the binding affinity. imidazole 14-23 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 33-49 17398093-0 2007 Imidazole moiety replacements in the 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) to improve cytochrome P450 profile. imidazole 0-9 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 155-170 10209701-6 1999 Concomitant administration with drugs that inhibit the hepatic cytochrome P-450 (imidazole antifungals, macrolide antibiotics) or those that prolong the QT interval by the same or other mechanism (e.g. antiarrhythmics, antipsychotics, tricyclic antidepressants) increases their effect on the cardiac repolarization. imidazole 81-90 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 63-79 16943206-0 2006 Cytochrome P450 active site plasticity: attenuation of imidazole binding in cytochrome P450(cam) by an L244A mutation. imidazole 55-64 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 16943206-0 2006 Cytochrome P450 active site plasticity: attenuation of imidazole binding in cytochrome P450(cam) by an L244A mutation. imidazole 55-64 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 76-91 8896115-0 1996 Effect of imidazole derivatives on cytochrome P-450 enzyme activities in a reconstructed human epidermis. imidazole 10-19 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 35-51 8995391-7 1997 The binding of chlorzoxazone to iNOS and human and rat liver microsomal cytochrome P-450 induced a high spin, type I spectra, which was reversed by imidazole. imidazole 148-157 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 72-88 7532106-3 1994 These studies involved the use of the imidazole antimycotics, econazole and miconazole, which are inhibitors of cytochrome P-450. imidazole 38-47 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 112-128 8068004-9 1994 We examined whether the inhibition of Ca2+ influx was due to an interaction of the inhibitor imidazole nitrogen with the haem iron of the putative cytochrome P-450 by comparing the activity of two compounds, identical except that one was methylated at the imidazole 2-position. imidazole 93-102 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 147-163 8043490-15 1994 Non-steroidal inhibitors of cytochrome P-450 enzymes, such as imidazole and triazole derivatives have been developed which are highly selective for aromatase. imidazole 62-71 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 28-44 8240252-2 1993 This hypothesis is based on the observations that inhibitors of cytochrome P-450, such as the imidazole antifungal agents, also inhibit influx of a calcium surrogate (manganese) into calcium-depleted platelets. imidazole 94-103 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 64-80