PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34189538-2 2021 We characterized CD4+ and CD8+ T-cell responses induced by AZD1222 vaccination in peripheral blood mononuclear cells (PBMCs) from 280 unique vaccine recipients aged 18-85 years who enrolled in the phase 2/3 COV002 trial. azd1222 59-66 CD4 molecule Homo sapiens 17-20 34189538-3 2021 Total spike-specific CD4+ T cell helper type 1 (Th1) and CD8+ T-cell responses were significantly increased in AZD1222-vaccinated adults of all ages following two doses of AZD1222. azd1222 111-118 CD4 molecule Homo sapiens 21-24 34189538-3 2021 Total spike-specific CD4+ T cell helper type 1 (Th1) and CD8+ T-cell responses were significantly increased in AZD1222-vaccinated adults of all ages following two doses of AZD1222. azd1222 172-179 CD4 molecule Homo sapiens 21-24 34189538-6 2021 T-cell receptor (TCR) beta sequences from vaccinated participants mapped against TCR sequences known to react to SARS-CoV-2 revealed substantial breadth and depth across the SARS-CoV-2 spike protein for the AZD1222-induced CD4+ and CD8+ T-cell responses. azd1222 207-214 CD4 molecule Homo sapiens 223-226 34189538-7 2021 Overall, AZD1222 vaccination induced a robust, polyfunctional Th1-dominated T-cell response, with broad CD4+ and CD8+ T-cell coverage across the SARS-CoV-2 spike protein. azd1222 9-16 CD4 molecule Homo sapiens 104-107 34189538-8 2021 One Sentence Summary: Polyfunctional CD4+ and CD8+ T-cell responses are elicited against the SARS-CoV-2 spike protein following vaccination with AZD1222. azd1222 145-152 CD4 molecule Homo sapiens 37-40