PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11990384-0	2002	Sexual dimorphism of the catechol-O-methyltransferase gene in narcolepsy is associated with response to modafinil.	Modafinil	104-113	catechol-O-methyltransferase	Homo sapiens	25-53	
12517283-5	2003	Among these, the functional polymorphism of the catechol-O-methyltransferase (COMT) gene is critically involved in the severity of narcolepsy and in the response to the stimulant modafinil.	Modafinil	179-188	catechol-O-methyltransferase	Homo sapiens	48-76	
12517283-5	2003	Among these, the functional polymorphism of the catechol-O-methyltransferase (COMT) gene is critically involved in the severity of narcolepsy and in the response to the stimulant modafinil.	Modafinil	179-188	catechol-O-methyltransferase	Homo sapiens	78-82	
11990384-3	2002	We have reported a sexual dimorphism and a strong effect of the COMT genotype on narcolepsy symptoms and hypothesized that response to modafinil treatment may be associated with the COMT genotype.	Modafinil	135-144	catechol-O-methyltransferase	Homo sapiens	64-68	
11990384-3	2002	We have reported a sexual dimorphism and a strong effect of the COMT genotype on narcolepsy symptoms and hypothesized that response to modafinil treatment may be associated with the COMT genotype.	Modafinil	135-144	catechol-O-methyltransferase	Homo sapiens	182-186	
11990384-4	2002	Here we confirm that COMT genotype distribution between men and women narcoleptics is associated with response to modafinil.	Modafinil	114-123	catechol-O-methyltransferase	Homo sapiens	21-25	
11990384-5	2002	In addition, the optimal daily dose of modafinil is approximately 100 mg lower in women narcoleptics and lower in all narcoleptics with low activity COMT genotype.	Modafinil	39-48	catechol-O-methyltransferase	Homo sapiens	149-153	
11990384-6	2002	Our results suggest that a sexual dimorphism in COMT activity affects the response to modafinil and probably to other dopaminergic stimulants.	Modafinil	86-95	catechol-O-methyltransferase	Homo sapiens	48-52	
20815183-0	2010	Effects of modafinil on the sleep EEG depend on Val158Met genotype of COMT.	Modafinil	11-20	catechol-O-methyltransferase	Homo sapiens	70-74	
20815183-1	2010	STUDY OBJECTIVES: Modafinil may promote wakefulness by increasing cerebral dopaminergic neurotransmission, which importantly depends on activity of catechol-O-methyltransferase (COMT) in prefrontal cortex.	Modafinil	18-27	catechol-O-methyltransferase	Homo sapiens	148-176	
20815183-1	2010	STUDY OBJECTIVES: Modafinil may promote wakefulness by increasing cerebral dopaminergic neurotransmission, which importantly depends on activity of catechol-O-methyltransferase (COMT) in prefrontal cortex.	Modafinil	18-27	catechol-O-methyltransferase	Homo sapiens	178-182	
20815183-10	2010	In contrast to caffeine, modafinil did not reduce EEG slow wave activity (0.75-4.5 Hz) in recovery sleep, yet specifically increased 3.0-6.75 Hz and > 16.75 Hz activity in NREM sleep in the Val/Val genotype of COMT.	Modafinil	25-34	catechol-O-methyltransferase	Homo sapiens	213-217	
20815183-11	2010	CONCLUSIONS: The Val158Met polymorphism of COMT modulates the effects of modafinil on the NREM sleep EEG in recovery sleep after prolonged wakefulness.	Modafinil	73-82	catechol-O-methyltransferase	Homo sapiens	43-47	
19037200-0	2009	Pharmacogenetics of modafinil after sleep loss: catechol-O-methyltransferase genotype modulates waking functions but not recovery sleep.	Modafinil	20-29	catechol-O-methyltransferase	Homo sapiens	48-76