PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21856437-0	2011	Different roles of p53 in the regulation of DNA damage caused by 1,2-heteroannelated anthraquinones and doxorubicin.	Anthraquinones	85-99	tumor protein p53	Homo sapiens	19-22	
32784977-8	2020	Furthermore, the anthraquinone-rich dichloromethane fraction displayed the highest anticancer activity when evaluated in a human hepatoma cancer cell line (HepG2), in which it induced increased apoptosis mediated by p53 and caspase activation.	Anthraquinones	17-30	tumor protein p53	Homo sapiens	216-219	
31753697-0	2020	Upregulation of p53 through induction of MDM2 degradation: Amino acid prodrugs of anthraquinone analogs.	Anthraquinones	82-95	tumor protein p53	Homo sapiens	16-19	
31324563-0	2019	Upregulation of p53 through induction of MDM2 degradation: Anthraquinone analogs.	Anthraquinones	59-72	tumor protein p53	Homo sapiens	16-19	
31324563-1	2019	In a previous study, a novel anthraquinone analog BW-AQ-101 was identified as a potent inducer of MDM2 degradation, leading to upregulation of p53 and apoptosis in cell culture studies.	Anthraquinones	29-42	tumor protein p53	Homo sapiens	143-146	
30370860-0	2019	Hydroxyl Group Difference between Anthraquinone Derivatives Regulate Different Cell Death Pathways via Nucleo-Cytoplasmic Shuttling of p53.	Anthraquinones	34-47	tumor protein p53	Homo sapiens	135-138	
26585176-0	2016	An anthraquinone derivative from Luffa acutangula induces apoptosis in human lung cancer cell line NCI-H460 through p53-dependent pathway.	Anthraquinones	3-16	tumor protein p53	Homo sapiens	116-119	
24853816-5	2014	The DNA sequence dependence of p53 oxidative dissociation was examined by electrophoretic mobility shift assays using oligonucleotides containing both synthetic and human p53 consensus sequences with an appended photooxidant, anthraquinone.	Anthraquinones	226-239	tumor protein p53	Homo sapiens	31-34	
18025460-2	2007	Here we describe the oxidation of a cell-cycle regulatory protein, p53, from a distance through DNA-mediated CT. A consensus p53 binding site as well as three DNA promoters regulated by p53 were synthesized containing a tethered DNA photooxidant, anthraquinone.	Anthraquinones	247-260	tumor protein p53	Homo sapiens	67-70	
16521213-10	2006	When only the data from the 11 patients treated with anthraquinone drug, mitoxantrone, were analyzed, however, the number of patients who showed poor response to treatment was significantly higher among the p53-positive patients (P=0.012), irrespective of the survival outcome.	Anthraquinones	53-66	tumor protein p53	Homo sapiens	207-210	
16521213-12	2006	Similarly, immunostaining to evaluate p53 protein may be useful to predict the response in patients treated with an anthraquinone drug.	Anthraquinones	116-129	tumor protein p53	Homo sapiens	38-41	
27044842-0	2016	The novel anthraquinone derivative IMP1338 induces death of human cancer cells by p53-independent S and G2/M cell cycle arrest.	Anthraquinones	10-23	tumor protein p53	Homo sapiens	82-85	
25611347-1	2015	Quinofuracins A-E, novel anthraquinone derivatives containing beta-D-galactofuranose that were isolated from the fungus Staphylotrichum boninense PF1444, induced p53-dependent cell death in human tumor cells.	Anthraquinones	25-38	tumor protein p53	Homo sapiens	162-165