PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26328495-0 2015 POMGNT1 Is Glycosylated by Mucin-Type O-Glycans. o-glycans 38-47 LOC100508689 Homo sapiens 27-32 26880333-6 2016 O-Glycosylation is also often called mucin-type glycosylation as it is typical for mucins that often have more than 80% of the mass as O-glycans. o-glycans 135-144 LOC100508689 Homo sapiens 37-42 26500890-8 2015 These results suggest that mucin O-glycans from tumors with recurrence might mimic a healthier physiological situation, hence deceiving the immune defense system. o-glycans 33-42 LOC100508689 Homo sapiens 27-32 25852737-3 2015 The O-glycan structures present in mucin are diverse and complex, consisting predominantly of core 1-4 mucin-type O-glycans containing alpha- and beta- linked N-acetyl-galactosamine, galactose and N-acetyl-glucosamine. o-glycans 114-123 LOC100508689 Homo sapiens 35-40 25852737-3 2015 The O-glycan structures present in mucin are diverse and complex, consisting predominantly of core 1-4 mucin-type O-glycans containing alpha- and beta- linked N-acetyl-galactosamine, galactose and N-acetyl-glucosamine. o-glycans 114-123 LOC100508689 Homo sapiens 103-108 25727146-0 2015 Simple sugars to complex disease--mucin-type O-glycans in cancer. o-glycans 45-54 LOC100508689 Homo sapiens 34-39 25727146-1 2015 Mucin-type O-glycans are a class of glycans initiated with N-acetylgalactosamine (GalNAc) alpha-linked primarily to Ser/Thr residues within glycoproteins and often extended or branched by sugars or saccharides. o-glycans 11-20 LOC100508689 Homo sapiens 0-5 25727146-3 2015 Alterations in mucin-type O-glycans have been described across tumor types and include expression of relatively small-sized, truncated O-glycans and altered terminal structures, both of which are associated with patient prognosis. o-glycans 26-35 LOC100508689 Homo sapiens 15-20 25727146-3 2015 Alterations in mucin-type O-glycans have been described across tumor types and include expression of relatively small-sized, truncated O-glycans and altered terminal structures, both of which are associated with patient prognosis. o-glycans 135-144 LOC100508689 Homo sapiens 15-20 25727146-5 2015 This chapter describes mucin-type O-glycan biosynthesis, altered mucin-type O-glycans in primary tumors, including mechanisms for structural changes and contributions to the tumor phenotype, and clinical approaches to detect and target altered O-glycans for cancer treatment and management. o-glycans 76-85 LOC100508689 Homo sapiens 65-70 25599098-6 2015 A trace amount of mucin O-glycans was permethylated by the open tubular reactor under low pressure without interference from the freezing of DMSO. o-glycans 24-33 LOC100508689 Homo sapiens 18-23 26328495-7 2015 We identified several mucin-type O-glycans containing (NeuAc)1(Hex)1(HexNAc)1, (NeuAc)2(Hex)1(HexNAc)1, and (NeuAc)2(Hex)2(HexNAc)2. o-glycans 33-42 LOC100508689 Homo sapiens 22-27 25124036-5 2014 Although blood group active O-glycans of the Lewis-type form the basis of H. pylori adhesion to the surface mucin layer and to epithelial cells, alpha1,4-GlcNAc-capped O-glycans on gastric mucins were proposed to inhibit H. pylori growth as a natural antibiotic. o-glycans 28-37 LOC100508689 Homo sapiens 108-113 23765652-0 2013 Study of the biological functions of mucin type core 3 O-glycans. o-glycans 55-64 LOC100508689 Homo sapiens 37-42 24307362-1 2013 By displaying different O-glycans in a multivalent mode, mucin and mucin-like glycoproteins are involved in a plethora of protein binding events. o-glycans 24-33 LOC100508689 Homo sapiens 57-62 24307362-1 2013 By displaying different O-glycans in a multivalent mode, mucin and mucin-like glycoproteins are involved in a plethora of protein binding events. o-glycans 24-33 LOC100508689 Homo sapiens 67-72 23325272-4 2013 On the apical glycocalyx, mucin O-glycans promote boundary lubrication, prevent bacterial adhesion and endocytic activity, and maintain epithelial barrier function through interactions with galectins. o-glycans 32-41 LOC100508689 Homo sapiens 26-31 20615996-8 2011 The numerous O-glycans on the MUC2 mucin not only serve as nutrients for the bacteria but also as attachment sites and, as such, probably contribute to the selection of the species-specific colon flora. o-glycans 13-22 LOC100508689 Homo sapiens 35-40 22329400-0 2012 Characterization of cancer associated mucin type O-glycans using the exchange sialylation properties of mammalian sialyltransferase ST3Gal-II. o-glycans 49-58 LOC100508689 Homo sapiens 38-43 22522599-0 2012 Almost all human gastric mucin O-glycans harbor blood group A, B or H antigens and are potential binding sites for Helicobacter pylori. o-glycans 31-40 LOC100508689 Homo sapiens 25-30 22522599-3 2012 Adhesion of the bacteria to the gastric mucosa is a necessary prerequisite for the pathogenesis of H. pylori-related diseases and is mediated by mucin O-glycans. o-glycans 151-160 LOC100508689 Homo sapiens 145-150 22522599-6 2012 We have also demonstrated that around 80% of O-glycans carried blood group A, B or H antigens, suggesting that the variation of gastric mucin glycosylation between individuals is partly due to the blood group status. o-glycans 45-54 LOC100508689 Homo sapiens 136-141 22815896-7 2012 The only gel-forming mucin produced in the colon is the Muc2 mucin and as it carries numerous O-glycans, the granulae of the goblet cells producing Muc2 mucin were intensely stained. o-glycans 94-103 LOC100508689 Homo sapiens 21-26 21177247-0 2011 Glycoside hydrolase family 89 alpha-N-acetylglucosaminidase from Clostridium perfringens specifically acts on GlcNAc alpha1,4Gal beta1R at the non-reducing terminus of O-glycans in gastric mucin. o-glycans 168-177 LOC100508689 Homo sapiens 189-194 20144722-0 2010 The role of mucin-type O-glycans in eukaryotic development. o-glycans 23-32 LOC100508689 Homo sapiens 12-17 20301232-2 2009 In mucins, O-glycans are covalently alpha-linked via an N-acetylgalactosamine (GalNAc) moiety to the -OH of serine or threonine by an O-glycosidic bond, and the structures are named mucin O-glycans or O-GalNAc glycans. o-glycans 11-20 LOC100508689 Homo sapiens 3-8 20024790-7 2010 The lectin from Amaranthus leucocarpus recognized only duct cells in control samples, whereas, in fibroadenoma tissue, it recognized duct and some stromal cells, suggesting that O-glycans-type mucin linked to proteins and mucin participate in the development of fibroadenomas. o-glycans 178-187 LOC100508689 Homo sapiens 193-198 20816164-1 2010 Recent studies demonstrated that mucin type O-glycans have important roles in tumorigenesis. o-glycans 44-53 LOC100508689 Homo sapiens 33-38 19556244-6 2009 Similarly, down-regulation of mucin O-glycosylation using a stable tetracycline-inducible RNA interfering system to knockdown c1galt1 (T-synthase), a critical galactosyltransferase required for the synthesis of core 1 O-glycans, resulted in decreased cell surface O-glycosylation, reduced cell surface galectin-3, and increased epithelial permeability. o-glycans 218-227 LOC100508689 Homo sapiens 30-35 20301232-2 2009 In mucins, O-glycans are covalently alpha-linked via an N-acetylgalactosamine (GalNAc) moiety to the -OH of serine or threonine by an O-glycosidic bond, and the structures are named mucin O-glycans or O-GalNAc glycans. o-glycans 188-197 LOC100508689 Homo sapiens 3-8 20301232-5 2009 In this chapter, however, the term O-glycan refers to mucin O-glycans, unless otherwise specified. o-glycans 60-69 LOC100508689 Homo sapiens 54-59 15788414-0 2005 Mouse large can modify complex N- and mucin O-glycans on alpha-dystroglycan to induce laminin binding. o-glycans 44-53 LOC100508689 Homo sapiens 38-43 18794288-2 2008 This study examined whether O-glycans, which constitute the majority of the mucin mass of epithelial cell glycocalyces, prevented bacterial adhesion and growth. o-glycans 28-37 LOC100508689 Homo sapiens 76-81 18794288-7 2008 Overall, these data indicate that mucin O-glycans contribute to the prevention of bacterial adherence to the apical surface of corneal epithelial cells and suggest that alteration of cell surface glycosylation from disease or trauma, including that stemming from contact lens wear, could contribute to a higher risk of infection. o-glycans 40-49 LOC100508689 Homo sapiens 34-39 16496270-3 2006 Alpha-dystroglycan is an O-mannosylated glycoprotein with additional mucin type O-glycans. o-glycans 80-89 LOC100508689 Homo sapiens 69-74 15955459-5 2005 Evidence is presented that extracellular matrix (ECM) proteins of skin are likely to be highly glycosylated with N- and/or mucin type O-glycans by using algorithms for predicting glycosylation. o-glycans 134-143 LOC100508689 Homo sapiens 123-128 18996345-7 2008 However, mucin O-glycans are the principal host substrate foraged in vivo. o-glycans 15-24 LOC100508689 Homo sapiens 9-14 18172093-0 2008 Antiadhesive character of mucin O-glycans at the apical surface of corneal epithelial cells. o-glycans 32-41 LOC100508689 Homo sapiens 26-31 18172093-2 2008 The purpose of this study was to evaluate the contribution of mucin O-glycans to the antiadhesive character of human corneal-limbal epithelial (HCLE) cells. o-glycans 68-77 LOC100508689 Homo sapiens 62-67 18172093-10 2008 The antiadhesive effect of mucin O-glycans was further demonstrated by fluorescence video microscopy in dynamic flow adhesion assays. o-glycans 33-42 LOC100508689 Homo sapiens 27-32 18172093-12 2008 CONCLUSIONS: These results indicate that epithelial O-glycans contribute to the antiadhesive properties of cell surface-associated mucins in corneal epithelial cells and suggest that alterations in mucin O-glycosylation are involved in the pathology of drying mucosal diseases (e.g., dry eye). o-glycans 52-61 LOC100508689 Homo sapiens 131-136 17890913-2 2007 Previously we showed that a monoclonal antibody HIK1083 directed to alpha1,4-GlcNAc-capped O-glycans expressed in gastric gland mucin reacts to gastric cancer cells. o-glycans 91-100 LOC100508689 Homo sapiens 128-133 16741504-0 2006 Mucin-type O-glycans in human colon and breast cancer: glycodynamics and functions. o-glycans 11-20 LOC100508689 Homo sapiens 0-5 16741504-2 2006 In particular, the mucin-type O-glycans have several cancer-associated structures, including the T and Tn antigens, and certain Lewis antigens. o-glycans 30-39 LOC100508689 Homo sapiens 19-24 15788414-11 2005 In addition, the data suggest that human LARGE may restore functional alpha-DG to muscle cells from patients with defective synthesis of O-mannose glycans via the modification of N-glycans and/or mucin O-glycans on alpha-DG. o-glycans 202-211 LOC100508689 Homo sapiens 196-201 13679364-0 2003 Polysialic acid and mucin type o-glycans on the neural cell adhesion molecule differentially regulate myoblast fusion. o-glycans 31-40 LOC100508689 Homo sapiens 20-25 15723833-2 2005 The peptide extension (denoted as CTP) is rich in mucin-type O-glycans and confers new hormonal properties on CG relative to the LH. o-glycans 61-70 LOC100508689 Homo sapiens 50-55 13679364-8 2003 These results indicate that polysialic acid and mucin type O-glycans on NCAM differentially regulate myoblast fusion, playing critical roles in muscle development. o-glycans 59-68 LOC100508689 Homo sapiens 48-53 13679364-2 2003 NCAM in muscle tissue contains a muscle-specific domain (MSD) to which mucin type O-glycans are attached. o-glycans 82-91 LOC100508689 Homo sapiens 71-76 12499379-5 2003 Lectin blot analysis using peanut agglutinin revealed that the mucin box of the enzyme is highly glycosylated with O-glycans. o-glycans 115-124 LOC100508689 Homo sapiens 63-68 14707484-1 2002 The O-glycans that decorate mucin glycoproteins contribute to the biophysical and biochemical properties of these molecules and hence their function as a barrier and lubricant on epithelial surfaces. o-glycans 4-13 LOC100508689 Homo sapiens 28-33 10712612-7 2000 Among O-glycans from an ovarian cystadenoma mucin, isomeric oligosaccharide sequences, sialyl-Lea- and sialyl-Lex-active, could be resolved by HPLC as fluorescent neoglycolipids, and sequenced by liquid secondary-ion mass spectrometry. o-glycans 6-15 LOC100508689 Homo sapiens 44-49 11984005-16 2002 In breast cancers, the MUC1 mucin is overexpressed and contains shorter O-glycans as compared to the normal mucin. o-glycans 72-81 LOC100508689 Homo sapiens 28-33 11984005-17 2002 Because STM catalyzes the synthesis of O-glycans, cloning and characterization of its substrate specificity will contribute to the understanding of the molecular mechanisms underlying the aberrant glycosylation patterns of O-glycans and the formation of mucin-related antigens in human breast cancers. o-glycans 39-48 LOC100508689 Homo sapiens 254-259 11547903-5 2001 In normal resting, pregnant and lactating breast, mucin O-glycans are largely extended (core 2 type) structures. o-glycans 56-65 LOC100508689 Homo sapiens 50-55 11547903-6 2001 In contrast, mucin O-glycans found in breast carcinomas are often truncated (core 1 type). o-glycans 19-28 LOC100508689 Homo sapiens 13-18 11777921-0 2002 Determination of the site-specific oligosaccharide distribution of the O-glycans attached to the porcine submaxillary mucin tandem repeat. o-glycans 71-80 LOC100508689 Homo sapiens 118-123 11591497-1 2001 A series of lactosaminylated oligosaccharides found in mucin type O-glycans was synthesized using a generalized block strategy. o-glycans 66-75 LOC100508689 Homo sapiens 55-60 8298304-0 1993 Preferred conformations and dynamics of five core structures of mucin type O-glycans determined by NMR spectroscopy and force field calculations. o-glycans 75-84 LOC100508689 Homo sapiens 64-69 11082759-2 2000 Nine mucin genes exist in humans that encode an apomucin highly modified by O-glycans in forming epithelial mucins. o-glycans 76-85 LOC100508689 Homo sapiens 5-10 9505887-5 1998 RESULTS: Of one crypt base cell specific antibody (5E9), the reactive epitope appeared to be a non-terminal carbohydrate in the mucin O-glycans of the colon. o-glycans 134-143 LOC100508689 Homo sapiens 128-133 10571020-4 1999 The O-glycans added to the mucin produced by the normal breast are core 2 based and can be complex, while the O-glycans added to the breast cancer mucin are mainly core 1 based. o-glycans 4-13 LOC100508689 Homo sapiens 27-32 10571020-4 1999 The O-glycans added to the mucin produced by the normal breast are core 2 based and can be complex, while the O-glycans added to the breast cancer mucin are mainly core 1 based. o-glycans 110-119 LOC100508689 Homo sapiens 147-152 34822462-2 2021 In humans, noroviruses are known to bind to gastrointestinal epithelia via recognition of blood-group active mucin-type O-glycans. o-glycans 120-129 LOC100508689 Homo sapiens 109-114 34803391-0 2021 Mucin-Type O-Glycans: Barrier, Microbiota, and Immune Anchors in Inflammatory Bowel Disease. o-glycans 11-20 LOC100508689 Homo sapiens 0-5 34803391-2 2021 The association of microbial and immune molecules with mucin-type O-glycans has been increasingly noticed by researchers. o-glycans 66-75 LOC100508689 Homo sapiens 55-60 34803391-4 2021 Mucin-type O-glycans alter the diversity of gastrointestinal microorganisms, which in turn increases the level of O-glycosylation of host intestinal proteins via the utilization of glycans. o-glycans 11-20 LOC100508689 Homo sapiens 0-5 34803391-5 2021 Additionally, alterations in mucin-type O-glycans not only increase the activity and stability of immune cells but are also involved in the maintenance of intestinal mucosal immune tolerance. o-glycans 40-49 LOC100508689 Homo sapiens 29-34 34803391-6 2021 Although there is accumulating evidence indicating that mucin-type O-glycans play an important role in IBD, there is limited literature that integrates available data to present a complete picture of exactly how O-glycans affect IBD. o-glycans 67-76 LOC100508689 Homo sapiens 56-61 34803391-6 2021 Although there is accumulating evidence indicating that mucin-type O-glycans play an important role in IBD, there is limited literature that integrates available data to present a complete picture of exactly how O-glycans affect IBD. o-glycans 212-221 LOC100508689 Homo sapiens 56-61 34803391-7 2021 This review emphasizes the roles of the mucin-type O-glycans in IBD. o-glycans 51-60 LOC100508689 Homo sapiens 40-45 34616040-6 2021 Here we show that sulfatases are essential to the utilization of distal colonic mucin O-glycans by the human gut symbiont Bacteroides thetaiotaomicron. o-glycans 86-95 LOC100508689 Homo sapiens 80-85 34733141-2 2021 Mucin-type O-glycans are often found on mucins in the mucous membranes of the digestive tract. o-glycans 11-20 LOC100508689 Homo sapiens 0-5 34733141-4 2021 Altered expression of mucin-type O-glycans is known to be associated with several human disorders, including Tn syndrome and cancer; however, the physiological roles of mucin-type O-glycans in the mammalian brain remains largely unknown. o-glycans 33-42 LOC100508689 Homo sapiens 22-27 34733141-4 2021 Altered expression of mucin-type O-glycans is known to be associated with several human disorders, including Tn syndrome and cancer; however, the physiological roles of mucin-type O-glycans in the mammalian brain remains largely unknown. o-glycans 33-42 LOC100508689 Homo sapiens 169-174 34733141-4 2021 Altered expression of mucin-type O-glycans is known to be associated with several human disorders, including Tn syndrome and cancer; however, the physiological roles of mucin-type O-glycans in the mammalian brain remains largely unknown. o-glycans 180-189 LOC100508689 Homo sapiens 22-27 34733141-4 2021 Altered expression of mucin-type O-glycans is known to be associated with several human disorders, including Tn syndrome and cancer; however, the physiological roles of mucin-type O-glycans in the mammalian brain remains largely unknown. o-glycans 180-189 LOC100508689 Homo sapiens 169-174 34733141-5 2021 The functions of mucin-type O-glycans have been studied in the fruit fly, Drosophila melanogaster. o-glycans 28-37 LOC100508689 Homo sapiens 17-22 34733141-6 2021 The basic structures of mucin-type O-glycans, including Tn antigen (GalNAcalpha1-Ser/Thr) and T antigen (Galbeta1-3GalNAcalpha1-Ser/Thr), as well as the glycosyltransferases that synthesize them, are conserved between Drosophila and mammals. o-glycans 35-44 LOC100508689 Homo sapiens 24-29 34733141-7 2021 These mucin-type O-glycans are expressed in the Drosophila nervous system, including the central nervous system (CNS) and neuromuscular junctions (NMJs). o-glycans 17-26 LOC100508689 Homo sapiens 6-11 34733141-8 2021 In primary cultured neurons of Drosophila, mucin-type O-glycans show a characteristic localization pattern in axons. o-glycans 54-63 LOC100508689 Homo sapiens 43-48 34733141-9 2021 Phenotypic analyses using mutants of glycosyltransferase genes have revealed that mucin-type O-glycans are required for CNS development, NMJ morphogenesis, and synaptic functions of NMJs in Drosophila. o-glycans 93-102 LOC100508689 Homo sapiens 82-87 34733141-10 2021 In this review, we describe the roles of mucin-type O-glycans in the Drosophila nervous system. o-glycans 52-61 LOC100508689 Homo sapiens 41-46 34733141-11 2021 These findings will provide insight into the functions of mucin-type O-glycans in the mammalian brain. o-glycans 69-78 LOC100508689 Homo sapiens 58-63 34627217-1 2021 BACKGROUND: To analyse over time changes in stimulated whole saliva regarding total protein, Immunoglobulin A (IgA), and mucin type O-glycans (mostly MUC5B and MUC7) in head and neck cancer patients. o-glycans 132-141 LOC100508689 Homo sapiens 121-126 34149900-3 2021 Core 1 synthase glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (C1GALT1) serves an important role in the regulation of O-glycosylation and is an essential enzyme for synthesizing the core 1 structure of mucin-type O-glycans. o-glycans 233-242 LOC100508689 Homo sapiens 222-227 34511650-0 2021 Decreased Gastric Gland Mucin-specific O-glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours. o-glycans 39-48 LOC100508689 Homo sapiens 24-29 34511650-2 2021 Gastric gland mucin-specific O-glycans are unique with an alpha1,4-linked N-acetylglucosamine (alphaGlcNAc) residue attached to mucin 6 (MUC6). o-glycans 29-38 LOC100508689 Homo sapiens 14-19 35353213-1 2022 Gastric gland mucin consists of core protein MUC6 with residues heavily glycosylated by unique O-glycans carrying alpha1,4-linked N-acetylglucosamine (alphaGlcNAc). o-glycans 95-104 LOC100508689 Homo sapiens 14-19 34101390-0 2021 Cellular O-Glycome Reporter/Amplification (CORA): Analytical and Preparative Tools to Study Mucin-Type O-Glycans of Living Cells. o-glycans 103-112 LOC100508689 Homo sapiens 92-97 34101390-1 2021 Mucin-type O-glycosylation (O-glycans, O-glycome) is among the most biologically important post-translational modification in glycoproteins but O-glycan structural diversity and expression are poorly understood due to the inadequacy of current analytical methods. o-glycans 28-37 LOC100508689 Homo sapiens 0-5 34101390-9 2021 Basic Protocol 1: Cellular O-glycome reporter/amplification for the analysis of mucin-type O-glycans from living cells Basic Protocol 2: Preparation of cellular O-glycans from living cells for functional glycomics and glycan microarrays Basic Protocol 3: Conjugation of cellular O-glycans with a bifunctional fluorescent tag Basic Protocol 4: 2D-HPLC purification and MALDI-TOF/MS identification of individual PYAB-Bn-O-glycan. o-glycans 91-100 LOC100508689 Homo sapiens 80-85 35563881-6 2022 Abortive clones were characterized by increased levels of GCNT4 and FUCA2, genes that are responsible for the branching of mucin-type O-glycans and the hydrolysis of fucose residues on N-glycans, respectively. o-glycans 134-143 LOC100508689 Homo sapiens 123-128 35207462-2 2022 Core 1 beta1-3 Galactosyltransferase (C1GALT1) is a primary enzyme that regulates the elongation of core 1-derived mucin-type O-glycans. o-glycans 126-135 LOC100508689 Homo sapiens 115-120 35504880-1 2022 C1GalT1 is an essential inverting glycosyltransferase responsible for synthesizing the core 1 structure, a common precursor for mucin-type O-glycans found in many glycoproteins. o-glycans 139-148 LOC100508689 Homo sapiens 128-133 35405095-5 2022 Here, we focus on the mucin-selective metalloprotease, Amuc_0627 (AM0627), which is known to cleave between adjacent residues carrying truncated core 1 O-glycans. o-glycans 152-161 LOC100508689 Homo sapiens 22-27 35486871-11 2022 Mucin glycomic analysis revealed significantly more sialylated glycans in CF and the total abundance of non-sulfated O-glycans was correlated with the relative abundance of pathogens. o-glycans 117-126 LOC100508689 Homo sapiens 0-5 35287047-1 2022 Access to mucin-type O-glycans as tools to help further our understanding of the biological role of these complex molecules is of importance. o-glycans 21-30 LOC100508689 Homo sapiens 10-15 33871988-4 2021 Recently, we introduced chemically modified monosaccharide analogues that allowed selective tracking and characterization of mucin-type O-glycans after bioorthogonal derivatization with biotin-based enrichment handles. o-glycans 136-145 LOC100508689 Homo sapiens 125-130 35380912-3 2022 This current review summarizes these findings by highlighting the emerging roles of mucus and mucin-type O-glycans in influencing host and microbial physiology with an emphasis on host defense strategies against bacteria in the gastrointestinal tract. o-glycans 105-114 LOC100508689 Homo sapiens 94-99 33068214-5 2021 However, O-glycosite mapping remains challenging since mucin-type O-glycans are densely packed, often protecting proteins from cleavage by proteases. o-glycans 66-75 LOC100508689 Homo sapiens 55-60 33087860-0 2021 Mucin-derived O-glycans supplemented to diet mitigate diverse microbiota perturbations. o-glycans 14-23 LOC100508689 Homo sapiens 0-5 33020993-4 2020 In normal gastric mucosa, gastric gland mucin-specific O-glycans are unique in having alpha1,4-linked N-acetylglucosamine (alphaGlcNAc) attached to MUC6. o-glycans 55-64 LOC100508689 Homo sapiens 40-45 33253272-1 2020 Mucin-type O-glycans are involved in cancer initiation and progression, although details of their biological and clinicopathological roles remain unclear. o-glycans 11-20 LOC100508689 Homo sapiens 0-5 32231096-4 2020 This species is likely to have adapted to efficiently degrade host-derived carbohydrate chains, such as human milk oligosaccharides (HMOs) and mucin O-glycans, which enabled the longitudinal colonization of intestines. o-glycans 149-158 LOC100508689 Homo sapiens 143-148 32539345-1 2020 Mucin type O-glycans play key roles in many cellular pro-cesses, and they are often altered in human diseases. o-glycans 11-20 LOC100508689 Homo sapiens 0-5 32620774-4 2020 The HMO pathways, which include enzymes with a previously unknown structural fold and specificity, were upregulated together with additional glycan-utilization loci during growth on selected HMOs and in co-cultures with Akkermansia muciniphila on mucin, suggesting an additional role in enabling cross-feeding and access to mucin O-glycans. o-glycans 330-339 LOC100508689 Homo sapiens 232-237 32620774-4 2020 The HMO pathways, which include enzymes with a previously unknown structural fold and specificity, were upregulated together with additional glycan-utilization loci during growth on selected HMOs and in co-cultures with Akkermansia muciniphila on mucin, suggesting an additional role in enabling cross-feeding and access to mucin O-glycans. o-glycans 330-339 LOC100508689 Homo sapiens 247-252 32404934-3 2020 Here, we demonstrate that all TFFs are divalent lectins that recognise the GlcNAc-alpha-1,4-Gal disaccharide, which terminates some mucin-like O-glycans. o-glycans 143-152 LOC100508689 Homo sapiens 132-137 31521614-0 2019 Mucin O-glycans facilitate symbiosynthesis to maintain gut immune homeostasis. o-glycans 6-15 LOC100508689 Homo sapiens 0-5 31521614-8 2019 Microbial utilisation of mucin-associated O-glycans was significantly reduced in n-butyrate-deficient UC patients. o-glycans 42-51 LOC100508689 Homo sapiens 25-30 31521614-9 2019 INTERPRETATION: Mucin O-glycans facilitate symbiosynthesis of n-butyrate by gut microbiota. o-glycans 22-31 LOC100508689 Homo sapiens 16-21 31638776-2 2019 Recently we reported a technology termed cellular O-glycome reporter/amplification (CORA) to amplify and profile mucin-type O-glycans of living cells growing in the presence of peracetylated Benzyl-alpha-GalNAc (Ac3GalNAc-alpha-Bn). o-glycans 124-133 LOC100508689 Homo sapiens 113-118 30392563-1 2018 Mucin glycoproteins on the ocular surface are rich in O-glycans and have important roles in the protection from physical, chemical and microbial impact. o-glycans 54-63 LOC100508689 Homo sapiens 0-5 30739313-1 2019 Mucin-type O-glycans have profound effects on the structure and stability of glycoproteins. o-glycans 11-20 LOC100508689 Homo sapiens 0-5 31063936-2 2019 Compared with N-glycans, the development of methods for mucin O-glycans has lagged behind and underrepresentation of O-glycans in any of the current microarray libraries have hampered their application in O-glycan recognition studies. o-glycans 62-71 LOC100508689 Homo sapiens 56-61 30338216-8 2018 Colonic mucin-derived O-glycans from control infants composed 37.68% (+- 3.14% SD) of the total glycan structure pool, whereas colonic mucin-derived O-glycans made up of only 1.78% (+- 0.038% SD) of the total in B. infantis EVC001 samples. o-glycans 22-31 LOC100508689 Homo sapiens 8-13 30338216-8 2018 Colonic mucin-derived O-glycans from control infants composed 37.68% (+- 3.14% SD) of the total glycan structure pool, whereas colonic mucin-derived O-glycans made up of only 1.78% (+- 0.038% SD) of the total in B. infantis EVC001 samples. o-glycans 149-158 LOC100508689 Homo sapiens 135-140 30338216-9 2018 The relative abundance of these colonic mucin-derived O-glycans in the total glycan pool was higher among control, 26.98% (+- 8.48% SD), relative to B. infantis-colonized infants, 1.68% (+- 1.12% SD). o-glycans 54-63 LOC100508689 Homo sapiens 40-45 29751628-0 2018 The Double Face of Mucin-Type O-Glycans in Lectin-Mediated Infection and Immunity. o-glycans 30-39 LOC100508689 Homo sapiens 19-24 28668893-1 2017 BACKGROUND: The aberrant glycosylation of mucin type O-glycans is thought to be associated with functional alteration of cancer cells, including adhesive properties, as well as their potential for invasion and metastasis. o-glycans 53-62 LOC100508689 Homo sapiens 42-47 28408479-5 2017 Mucin O-glycans exhibit a huge variety of peripheral sequences implicated in the binding of bacteria to the mucosal tissues, thereby playing a key role in the selection of specific species and in the tissue tropism displayed by commensal and pathogenic bacteria. o-glycans 6-15 LOC100508689 Homo sapiens 0-5 28408479-8 2017 This review summarizes the current knowledge on the structure of epithelial mucin O-glycans and the interaction between host and commensal or pathogenic bacteria mediated by mucins. o-glycans 82-91 LOC100508689 Homo sapiens 76-81