PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30532537-3	2018	Our previous study found that BU can effectively reverse P-glycoprotein (P-gp)-mediated MDR in colon cancer.	bufalin	30-32	ATP binding cassette subfamily B member 1	Homo sapiens	73-77	
25618972-8	2014	Preincubation of 0.001 mumol/L bufalin for 2 h could increase intracellular ADM fluorescence intensity to 28.07% (P < 0.05) and down-regulate MRP1 expression simultaneously, but no remarkable effect was found on P-gp protein.	bufalin	31-38	ATP binding cassette subfamily B member 1	Homo sapiens	215-219	
30532537-3	2018	Our previous study found that BU can effectively reverse P-glycoprotein (P-gp)-mediated MDR in colon cancer.	bufalin	30-32	ATP binding cassette subfamily B member 1	Homo sapiens	57-71	
28624793-3	2017	The purpose of this present study was to investigate the reversal effect of BU on ABCB1-mediated multidrug resistance in colorectal cancer.	bufalin	76-78	ATP binding cassette subfamily B member 1	Homo sapiens	82-87	
28624793-4	2017	BU at safe concentration (5, 10, 20 nM) could reverse chemosensitivity of ABCB1-overexpression HCT8/ADR, LoVo/ADR and HCT8/ABCB1 nearly back to their parental cells level.	bufalin	0-2	ATP binding cassette subfamily B member 1	Homo sapiens	74-79	
28624793-4	2017	BU at safe concentration (5, 10, 20 nM) could reverse chemosensitivity of ABCB1-overexpression HCT8/ADR, LoVo/ADR and HCT8/ABCB1 nearly back to their parental cells level.	bufalin	0-2	ATP binding cassette subfamily B member 1	Homo sapiens	123-128	
28624793-6	2017	Furthermore, Western blot assays showed that BU significantly inhibited the expression level of ABCB1 protein.	bufalin	45-47	ATP binding cassette subfamily B member 1	Homo sapiens	96-101	
28624793-7	2017	Meanwhile, BU stimulated the ATPase activity of ABCB1, which suggested that BU might be a substrate of ABCB1.	bufalin	11-13	ATP binding cassette subfamily B member 1	Homo sapiens	48-53	
28624793-7	2017	Meanwhile, BU stimulated the ATPase activity of ABCB1, which suggested that BU might be a substrate of ABCB1.	bufalin	11-13	ATP binding cassette subfamily B member 1	Homo sapiens	103-108	
28624793-7	2017	Meanwhile, BU stimulated the ATPase activity of ABCB1, which suggested that BU might be a substrate of ABCB1.	bufalin	76-78	ATP binding cassette subfamily B member 1	Homo sapiens	48-53	
28624793-7	2017	Meanwhile, BU stimulated the ATPase activity of ABCB1, which suggested that BU might be a substrate of ABCB1.	bufalin	76-78	ATP binding cassette subfamily B member 1	Homo sapiens	103-108	
28624793-8	2017	More interestingly, docking analysis predicted that BU could be docked into the large hydrophobic drug-binding cavity of human ABCB1.	bufalin	52-54	ATP binding cassette subfamily B member 1	Homo sapiens	127-132	
24173654-10	2014	Bufalin significantly arrested the cell cycle at the G0/G1 phase, induced apoptosis through an increase in the Bax/Bcl-xL ratio, inhibited drug efflux pump activity via downregulation of MRP1, and reduced the expression of TS in BEL-7402/5-FU cells.	bufalin	0-7	ATP binding cassette subfamily B member 1	Homo sapiens	187-191