PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8063619-3 1994 HL-60, ML1, and U937 leukemia cells treated with bufalin at 10(-8) M and above had condensed and fragmented nuclei. bufalin 49-56 interleukin 17F Homo sapiens 7-10 7658701-2 1995 In the present study, we found that bufalin at concentrations of 10(-7) M and higher induced apoptosis in human leukemia cells, such as HL60, ML1, but not in mouse leukemia M1 cells. bufalin 36-43 interleukin 17F Homo sapiens 142-145 1324788-2 1992 The present work was carried out to examine further the effect of bufalin on the growth and characteristics of human leukemia-derived cell lines U937, ML1, and HL60. bufalin 66-73 interleukin 17F Homo sapiens 151-154 1324788-3 1992 At concentrations of 5-10 nM, bufalin decreased the growth of ML1 cells preferentially at the G2 phase and U937 cells at the S and G2 phases of the cell cycle. bufalin 30-37 interleukin 17F Homo sapiens 62-65 1324788-4 1992 Bufalin, under these conditions, induced the differentiation of U937, ML1, and HL60 cells to monocyte/macrophage-like cells by measuring the expression of various differentiation markers, as assessed by morphology and histochemistry, and ability to phagocytose latex particles, to reduce nitroblue tetrazolium, and to develop Fc receptors. bufalin 0-7 interleukin 17F Homo sapiens 70-73 1324788-5 1992 U937 and ML1 cells started to differentiate at 4 and 6 h, respectively, after treatment with 10 nM bufalin and showed maximum differentiation 72 h later. bufalin 99-106 interleukin 17F Homo sapiens 9-12 1859424-2 1991 Bufalin, at a concentration as low as 10 nM, also produced a strong differentiation-inducing activity in three other human leukemia-derived cell lines (human promyelocytic HL60, monoblastic U937 and myeloblastic ML1). bufalin 0-7 interleukin 17F Homo sapiens 212-215