PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21913902-7 2012 Bufalin and cinobufagin also inhibited StAR protein expression and SF-1 binding to StAR gene promoter. bufalin 0-7 steroidogenic acute regulatory protein Homo sapiens 39-43 21913902-7 2012 Bufalin and cinobufagin also inhibited StAR protein expression and SF-1 binding to StAR gene promoter. bufalin 0-7 steroidogenic acute regulatory protein Homo sapiens 83-87 21913902-9 2012 Furthermore, U0126 reversed the inhibitory effects of bufalin and cinobufagin on StAR protein expression and the binding of SF-1 to StAR gene promoter. bufalin 54-61 steroidogenic acute regulatory protein Homo sapiens 81-85 21913902-9 2012 Furthermore, U0126 reversed the inhibitory effects of bufalin and cinobufagin on StAR protein expression and the binding of SF-1 to StAR gene promoter. bufalin 54-61 steroidogenic acute regulatory protein Homo sapiens 132-136 21913902-11 2012 CONCLUSIONS AND IMPLICATIONS: The inhibitory effects of bufalin and cinobufagin on steroidogenesis of aldosterone and cortisol were associated with inhibition of aldosterone synthase and 11beta-hydroxylase, as well as the suppression of StAR protein expression and SF-1 binding to StAR promoter via the phosphorylation of ERK1/2 in H295 cells. bufalin 56-63 steroidogenic acute regulatory protein Homo sapiens 237-241 21913902-11 2012 CONCLUSIONS AND IMPLICATIONS: The inhibitory effects of bufalin and cinobufagin on steroidogenesis of aldosterone and cortisol were associated with inhibition of aldosterone synthase and 11beta-hydroxylase, as well as the suppression of StAR protein expression and SF-1 binding to StAR promoter via the phosphorylation of ERK1/2 in H295 cells. bufalin 56-63 steroidogenic acute regulatory protein Homo sapiens 281-285