PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29805658-0	2018	Bufalin induces apoptosis in human esophageal carcinoma ECA109 cells by inhibiting the activation of the mTOR/p70S6K pathway.	bufalin	0-7	ribosomal protein S6 kinase B1	Homo sapiens	110-116	
30468278-10	2019	Therefore, our data provide evidence that bufalin induces autophagy in MGC803 cells via both Akt/mTOR/p70S6K and ERK signaling pathways, and Cbl-b-mediated suppression of mTOR and activation of ERK1/2 might play an important role.	bufalin	42-49	ribosomal protein S6 kinase B1	Homo sapiens	102-108	
28656204-1	2017	The aim of this study was to investigate the effects of bufalin on the mammalian target of rapamycin (mTOR/p70S6 kinase (p70S6K) signaling pathway and cell apoptosis in orthotopically transplanted tumors in nude mice.	bufalin	56-63	ribosomal protein S6 kinase B1	Homo sapiens	121-127	
29805658-1	2018	The present study examined whether bufalin could induce human esophageal carcinoma ECA109 cells apoptosis via inhibiting the activation of mechanistic target of rapamycin (mTOR)/p70 S6 kinase (p70S6K) pathway is discussed in this article.	bufalin	35-42	ribosomal protein S6 kinase B1	Homo sapiens	193-199	
29805658-2	2018	The present study used the esophageal squamous cell carcinoma ECA109 cell line to assess the apoptosis-inducing effects of bufalin via inhibition of the mTOR/p70S6K pathways.	bufalin	123-130	ribosomal protein S6 kinase B1	Homo sapiens	158-164	
29805658-7	2018	The levels of p-p70S6K and cIAP-1 were significantly higher in the wtmTOR-transfected group than in the control and empty vector-transfected groups, and then reduced following addition of bufalin; however, BAD expression was significantly lower in the wtmTOR-transfected group.	bufalin	188-195	ribosomal protein S6 kinase B1	Homo sapiens	16-22	
29805658-9	2018	In conclusion, the findings of the present study demonstrated that bufalin induced apoptosis in esophageal carcinoma cells via the inhibition of the mTOR/p70S6K pathway and indicated that treatment with bufalin could be combined with chemotherapy to overcome the resistance of esophageal carcinoma cells to chemotherapeutic-induced apoptosis.	bufalin	67-74	ribosomal protein S6 kinase B1	Homo sapiens	154-160	
29805658-9	2018	In conclusion, the findings of the present study demonstrated that bufalin induced apoptosis in esophageal carcinoma cells via the inhibition of the mTOR/p70S6K pathway and indicated that treatment with bufalin could be combined with chemotherapy to overcome the resistance of esophageal carcinoma cells to chemotherapeutic-induced apoptosis.	bufalin	203-210	ribosomal protein S6 kinase B1	Homo sapiens	154-160