PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21922632-0	2014	Bufalin-inhibited migration and invasion in human osteosarcoma U-2 OS cells is carried out by suppression of the matrix metalloproteinase-2, ERK, and JNK signaling pathways.	bufalin	0-7	matrix metallopeptidase 2	Homo sapiens	113-139	
33530915-7	2021	After inhibiting autophagy, Bufalin significantly inhibited the protein expression of P-AKT, Cyclin D1, MMP-2, MMP-9 and VEGF in HCC-LM3 cells.	bufalin	28-35	matrix metallopeptidase 2	Homo sapiens	104-109	
26446205-0	2015	Bufalin Inhibits NCI-H460 Human Lung Cancer Cell Metastasis In Vitro by Inhibiting MAPKs, MMPs, and NF-kappaB Pathways.	bufalin	0-7	matrix metallopeptidase 2	Homo sapiens	90-94	
23949904-0	2015	Bufalin inhibits migration and invasion in human hepatocellular carcinoma SK-Hep1 cells through the inhibitions of NF-kB and matrix metalloproteinase-2/-9-signaling pathways.	bufalin	0-7	matrix metallopeptidase 2	Homo sapiens	125-151	
23949904-7	2015	Furthermore, bufalin markedly inhibited MMP-2 and -9 activity, mRNA expression and protein levels in SK-Hep1 cells.	bufalin	13-20	matrix metallopeptidase 2	Homo sapiens	40-52	
23949904-10	2015	Based on these observations, we propose that bufalin is acts as an antiinvasive agent by inhibiting MMP-2 and -9 and involving PI3K/AKT and NF-kappaB pathways.	bufalin	45-52	matrix metallopeptidase 2	Homo sapiens	100-112	
27634330-7	2016	Bufalin could downregulate the downstream target molecules of MMP-2, MMP-9, beta-catenin and VEGF in liver cancer cells by influencing the Gli1 and Gli3 expression of Hh signaling pathway, and upregulate the E-cadherin expression of liver cancer cells by influencing the Gli3 expression of Hh signaling pathway.	bufalin	0-7	matrix metallopeptidase 2	Homo sapiens	62-67	
21922632-8	2014	Bufalin also suppressed the protein level of MMP-2 and reduced the levels of mitogen-activated protein kinases (MAPKs) such as JNK1/2 and ERK1/2 signals in U-2 OS cells.	bufalin	0-7	matrix metallopeptidase 2	Homo sapiens	45-50	
21922632-9	2014	Our results suggest that signaling pathways for bufalin-inhibited migration and invasion of U-2 OS cells might be mediated through blocking MAPK signaling and resulting in the inhibition of MMP-2.	bufalin	48-55	matrix metallopeptidase 2	Homo sapiens	190-195	
23870199-8	2013	In addition, treatment with bufalin significantly decreased the levels of pAKT, pGSK3beta, MMP-9, and MMP-2, while increasing the levels of GSK3beta and E-cadherin and suppressing the nuclear translocation of beta-catenin.	bufalin	28-35	matrix metallopeptidase 2	Homo sapiens	102-107