PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34352351-0 2021 3,5,6-trichloro-2-pyridinol intensifies the effect of chlorpyrifos on the paracrine function of Sertoli cells by preventing binding of testosterone and the androgen receptor. 3,5,6-trichloro-2-pyridinol 0-27 androgen receptor Homo sapiens 156-173 34352351-9 2021 Western blotting indicated that TCP and CPF both decreased expression of AR and cAMP-response element binding protein phosphorylation, while DEP had no effect in Sertoli cells, which are important in regulating paracrine function of Sertoli cells. 3,5,6-trichloro-2-pyridinol 32-35 androgen receptor Homo sapiens 73-75 34352351-10 2021 The fluorescence measurements and docking studies revealed that testosterone, CPF and TCP showed four types of intermolecular interactions with AR, highlighting alkyl bonds with some of the same amino acids. 3,5,6-trichloro-2-pyridinol 86-89 androgen receptor Homo sapiens 144-146 34352351-11 2021 Compared with testosterone, CPF and TCP also showed significant synergistic interaction with AR. 3,5,6-trichloro-2-pyridinol 36-39 androgen receptor Homo sapiens 93-95