PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10363899-13	1999	An inhibitor of the caspase-3 (Z-VAD-fmk) reduced apoptosis in both thymus and spleen.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	31-40	caspase 3	Mus musculus	20-29	
10754295-2	2000	This up-regulation was completely blocked by the cysteine protease inhibitor Z-VAD-fmk (benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone), whereas DEVD-CHO (succinyl-Asp-Glu-Val-Asp-aldehyde), a caspase 3 inhibitor, had no effect.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	77-86	caspase 3	Mus musculus	195-204	
9792795-3	1998	The redistribution of Bax is not inhibited by a caspase inhibitor, zVAD-fmk, which blocks caspase-3 activity and prevents apoptosis in vivo.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	67-75	caspase 3	Mus musculus	90-99	
10200549-8	1999	Following IL-3 withdrawal, the caspase inhibitors z-VAD.fmk and boc-asp(OMe)fluoromethylketone (boc-asp.fmk) prevented the cleavage and activation of caspase-3, the breakdown of lamin B1 and partially mitigated PARP degradation.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	50-59	caspase 3	Mus musculus	150-159	
29843152-10	2018	Conversely, the antioxidant N-Acetyl-L-cysteine (NAC) and pan-caspase inhibitor z-VAD-fmk attenuated RA-induced apoptosis by scavenging ROS and inactivating caspase-3.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	80-89	caspase 3	Mus musculus	157-166	
9692710-6	1998	Moreover, pretreatment of ventral mesencephalon cultures with the tetrapeptide inhibitors of the caspase-3-like proteases zVAD-FMK or Ac-DEVD-CHO specifically inhibit death of dopamine neurons induced by low concentrations of 1-methyl-4-phenylpyridinium, whereas the caspase-1-like inhibitor Ac-YVAD-CHO was without effect.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	122-130	caspase 3	Mus musculus	97-106	
8976202-2	1996	The CPP-32-like protease activity in apoptotic cell lysates was blocked by both the ICE inhibitor Cbz-Val-Ala-Asp(OMe)-fluoromethyl ketone (ZVAD-FMK) as well as its truncated analog Boc-Asp(OMe)-fluoromethyl ketone (BD-FMK), which failed to block ICE.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	98-138	caspase 3	Mus musculus	4-10	
33396178-8	2021	Inhibition of caspase with pan-caspase inhibitor, Z-VAD-FMK, prevented MC3T3-E1 subclone 14 cells from cadmium-induced reduction of Runx2, STC2, caspase 9, and accumulation of cleaved PARP and cleaved caspase 3.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	50-59	caspase 3	Mus musculus	201-210	
31124136-15	2019	Caspase inhibition (Z-VAD-FMK, 50 microm) attenuated cell death with immunostaining for annexin V, cytochrome C, and caspases 3 and 9 pointing to induction of intrinsic apoptosis during H2 O2 exposure.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	20-29	caspase 3	Mus musculus	117-133	
31289573-7	2019	Western blotting demonstrated that caspases-3, -8 and -9, and poly(ADP-ribose) polymerase protein levels were increased compared with untreated MA-10 cells; however, the caspase inhibitor, Z-VAD-fmk, reversed these effects.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	189-198	caspase 3	Mus musculus	35-56	
8976202-2	1996	The CPP-32-like protease activity in apoptotic cell lysates was blocked by both the ICE inhibitor Cbz-Val-Ala-Asp(OMe)-fluoromethyl ketone (ZVAD-FMK) as well as its truncated analog Boc-Asp(OMe)-fluoromethyl ketone (BD-FMK), which failed to block ICE.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	140-148	caspase 3	Mus musculus	4-10	
25737433-7	2015	CFZ and z-VAD-fmk treatments resulted in higher levels of caspase-3 and BAX and lower level of BCL-XL in gastrocnemius muscles and altered the level of proteins in the renin-angiotensin system.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	8-17	caspase 3	Mus musculus	58-67	
28396364-7	2017	In fact, activation of several proapoptotic markers (caspase-9, caspase-3, and PARP) and reversion of the cytotoxic effect upon treatment with an apoptosis inhibitor (Z-VAD-FMK) were observed.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	167-176	caspase 3	Mus musculus	64-73	
29931936-0	2017	[Effects of caspase inhibitor z-VAD-fmk on the expressions of calumenin, caspase-3, GRP78 and GRP94 in adriamycin-injured cardiomyocytes].	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	30-39	caspase 3	Mus musculus	73-82	
29931936-1	2017	OBJECTIVE: To study the effects of Caspase broad spectrum inhibitor Z-VAD-FMK on the expressions of calumenin,caspase-3, GRP78 and GRP94 in adriamycin-injured cardiomyocytes and to discuss whether there is a regulation relationship between calumenin and endo-plasmic reticulum stress and myocardial apoptosis.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	68-77	caspase 3	Mus musculus	110-119	
25391371-13	2015	In addition, z-VAD-fmk, a universal inhibitor of caspases, prevented activation of cleavage caspase-3 and abrogates cell death induced by thiostrepton treatment.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	13-22	caspase 3	Mus musculus	92-101	
27450912-13	2016	Caspase-3 mRNA expression was 4.75-fold higher in Z-VAD-FMK treated explants compared to control on day 1 (p < 0.001).	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	50-59	caspase 3	Mus musculus	0-9	
23446753-9	2013	The apoptosis of Hepa1-6 cells induced by the combination treatment with curcumin and resveratrol was accompanied by caspase-3, -8 and -9 activation, which was completely abrogated by a pan caspase inhibitor, Z-VAD-FMK.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	209-218	caspase 3	Mus musculus	117-137	
24325816-5	2014	In contrast, blockade of caspase-3 activity by zVADfmk resulted in a significant reduction of cleaved vimentin and secreted vimentin into the culture supernatant.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	47-54	caspase 3	Mus musculus	25-34	
24122153-9	2014	Moreover, both 3-MA and necrostatin-1 treatment could suppress cleaved caspase-3 and LC3-II production, whereas zVAD treatment could inhibit caspase-3 cleavage but increased LC3-II protein levels at 72 h after ICH.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	112-116	caspase 3	Mus musculus	141-150	
17620508-9	2007	Sustained agonism by beta1AR autoantibodies elicited caspase-3 activation, cardiomyocyte apoptosis, and DCM in vivo, and these processes were prevented by in vivo treatment with the pan-caspase inhibitor Z-VAD-FMK.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	204-213	caspase 3	Mus musculus	53-62	
22613767-11	2012	Indeed, zVAD-fmk inhibited effector caspases (caspases-3, -6, -7) as expected but increased caspase-9 cleavage and activity in etoposide-treated MEFs.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	8-16	caspase 3	Mus musculus	46-64	
20861832-4	2011	Treatment of LVS-infected bone-marrow-derived macrophages with a pancaspase inhibitor (zVAD) did not alter bacterial replication, but minimized active caspase-3 and other markers (Annexin V and propidium iodide) of cell death, whereas treatment with both rIL-4 and zVAD resulted in concomitant reduction of both parameters, suggesting that inhibition of bacterial replication by IL-4 was independent of caspase activation.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	87-91	caspase 3	Mus musculus	151-160	
19513564-4	2009	Apoptosis was established as a mechanism of cell death by demonstrating increased production of the p17 activated fragment of caspase-3 by cancer cells in response to Fv-FOXP3 and inhibition of cell killing by the caspase inhibitor, Z-VAD-FMK.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	233-242	caspase 3	Mus musculus	126-135	
21678460-10	2012	Biselyngbyaside also induced apoptosis accompanied by the induction of caspase-3 activation and nuclear condensation, and these effects were negated by the pancaspase inhibitor z-VAD-FMK.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	177-186	caspase 3	Mus musculus	71-80	
19524568-11	2009	p53 and apoptosis markers, caspase-3 and PARP-1 were activated after RGC-5 cells were cultured in glucose-free media for 32 h. Z-VAD-fmk, a pan-caspase inhibitor, was sufficient to prevent apoptosis.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	127-136	caspase 3	Mus musculus	27-36	
16675471-9	2006	Both HA- and RES-induced cleavage of caspase-9 and caspase-3 and PARP were completely blocked by a pan caspase inhibitor, Z-VAD-FMK.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	122-131	caspase 3	Mus musculus	51-60	
15028782-4	2004	All toxicants induced 8- to 50-fold increases in caspase-3 activities, which were completely inhibited by the pan caspase inhibitor ZVAD-fmk.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	132-140	caspase 3	Mus musculus	49-58	
15891331-12	2005	The administration of zVAD significantly inhibited myocardial caspase-3 activity and preserved cardiac physiologic function (Langendorff preparation).	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	22-26	caspase 3	Mus musculus	62-71	
12857937-5	2003	Silica-induced apoptosis and caspase 3 activation were, in part, caspase 9 dependent, as determined by their sensitivity to either a general caspase inhibitor (Z-VAD-FMK) or a specific caspase 9 inhibitor (Z-LEHD-FMK).	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	160-169	caspase 3	Mus musculus	29-38	
15093249-7	2004	In addition to positive immunoreactivity against the active fragment (p17) of caspase-3, the administration of the pan-caspase inhibitor, zVAD-fmk (40 microM), prevents apoptosis.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	138-146	caspase 3	Mus musculus	78-87	
11781185-7	2001	IFN-gamma-mediated apoptosis is associated with caspase-3 activation that can be prevented by the addition of the broad caspase inhibitor zVAD-fmk.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	138-146	caspase 3	Mus musculus	48-57	
12832530-6	2003	Consequently, cotreatment with a caspase inhibitor (zVAD-fmk) or with an antioxidant (N-acetylcysteine) not only deterred 6-OHDA-induced loss of TH-positive neurons but also abolished the appearance of activated caspase-3 in TH-positive neurons.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	52-60	caspase 3	Mus musculus	212-221	
12354286-5	2002	Caspase-3 activation was inhibited by M-CSF treatment to the same degree as with the caspase inhibitor Z-VAD-FMK.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	103-112	caspase 3	Mus musculus	0-9	
12627324-6	2003	RESULTS: Dose-dependent and time-dependent apoptosis of the cells, concommittant with an activation of caspase-3, were suppressed by the caspase inhibitors zVAD-fmk and zDEVD-fmk.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	156-164	caspase 3	Mus musculus	103-112	
12048029-6	2002	By using specific caspase inhibitors (Ac-DEVD-CHO, Ac-IETD-CHO and zVAD-fmk), we showed that caspase-3 and -7 (DEVDases) are major effector caspases during EV-induced apoptosis in permissive L929 and RK-13 cell cultures.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	67-75	caspase 3	Mus musculus	93-102	
11847519-2	2002	The activity of caspase-3 was enhanced during macrophage apoptosis induced by butyrate and the caspase inhibitor z-VAD-FMK (100 microM) inhibited the butyrate effect, indicating the major role of the caspase cascade in the process.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	113-122	caspase 3	Mus musculus	16-25	
11483620-5	2001	Activation of caspase-3-like enzyme occurred after addition of lysosphingolipids followed by incubation at 37 degrees C for 24 h. The addition of an inhibitor of caspases, ZVAD-fmk, to the Neuro2a cell culture completely inhibited the elevation of caspase-3 activity but not the DNA fragmentation.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	172-180	caspase 3	Mus musculus	248-257	
11488539-8	2001	zVAD-fmk, a broad-spectrum caspase inhibitor, prevented A beta 25-35-induced increase in caspase-3 activity and CEC death.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	0-8	caspase 3	Mus musculus	89-98