PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33737009-5 2021 Computational docking analysis together with quantum chemistry calculation shows that galangin can bind inside the peroxidase active sites of COX-1 and COX-2 in a similar manner as quercetin, but it has little ability to effectively donate its electrons, thereby blocking the effect of the reducing cosubstrates like quercetin. galangin 86-94 mitochondrially encoded cytochrome c oxidase I Homo sapiens 142-147 33737009-6 2021 Further experimental studies confirm that galangin can inhibit, both in vitro and in vivo, quercetin-mediated activation of the peroxidase activity of the COX-1/2 enzymes. galangin 42-50 mitochondrially encoded cytochrome c oxidase I Homo sapiens 155-162 33737009-7 2021 The results of the present study demonstrate that galangin is a novel naturally-occurring inhibitor of COX-1 and COX-2, acting by blocking the function of the reducing cosubstrates at the peroxidase sites. galangin 50-58 mitochondrially encoded cytochrome c oxidase I Homo sapiens 103-108 22806885-6 2012 3,5,7-Trihydroxyflavone was able to inhibit both COX-1 and COX-2, which makes it a dual inhibitor of COX and 5-LOX pathways and, therefore, a promising candidate for a new therapeutic option in the treatment of inflammatory processes. galangin 0-23 mitochondrially encoded cytochrome c oxidase I Homo sapiens 49-54