PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22806885-6	2012	3,5,7-Trihydroxyflavone was able to inhibit both COX-1 and COX-2, which makes it a dual inhibitor of COX and 5-LOX pathways and, therefore, a promising candidate for a new therapeutic option in the treatment of inflammatory processes.	galangin	0-23	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	49-54	
33737009-5	2021	Computational docking analysis together with quantum chemistry calculation shows that galangin can bind inside the peroxidase active sites of COX-1 and COX-2 in a similar manner as quercetin, but it has little ability to effectively donate its electrons, thereby blocking the effect of the reducing cosubstrates like quercetin.	galangin	86-94	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	142-147	
33737009-6	2021	Further experimental studies confirm that galangin can inhibit, both in vitro and in vivo, quercetin-mediated activation of the peroxidase activity of the COX-1/2 enzymes.	galangin	42-50	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	155-162	
33737009-7	2021	The results of the present study demonstrate that galangin is a novel naturally-occurring inhibitor of COX-1 and COX-2, acting by blocking the function of the reducing cosubstrates at the peroxidase sites.	galangin	50-58	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	103-108