PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29156544-10 2017 Conclusions:C. membranaceus uses the ceramide pathway by modulating the SphK1/SphK2 ratio and increasing SPL to generate oxidative stress and consequently apoptosis. Ceramides 37-45 sphingosine-1-phosphate lyase 1 Homo sapiens 105-108 21368890-8 2011 SPL acts through a novel feedback mechanism that amplifies stress-induced ceramide accumulation, and downregulation/inhibition of either SPL or ASMase prevents premature cell cycle progression and mitotic death. Ceramides 74-82 sphingosine-1-phosphate lyase 1 Homo sapiens 0-3 22784711-8 2012 In contrast, enforced expression of SPL sensitized cancer cells to irradiation or docetaxel by tilting the ceramide/S1P balance toward cell death. Ceramides 107-115 sphingosine-1-phosphate lyase 1 Homo sapiens 36-39