PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21368890-8	2011	SPL acts through a novel feedback mechanism that amplifies stress-induced ceramide accumulation, and downregulation/inhibition of either SPL or ASMase prevents premature cell cycle progression and mitotic death.	Ceramides	74-82	sphingosine-1-phosphate lyase 1	Homo sapiens	0-3	
29156544-10	2017	Conclusions:C. membranaceus uses the ceramide pathway by modulating the SphK1/SphK2 ratio and increasing SPL to generate oxidative stress and consequently apoptosis.	Ceramides	37-45	sphingosine-1-phosphate lyase 1	Homo sapiens	105-108	
22784711-8	2012	In contrast, enforced expression of SPL sensitized cancer cells to irradiation or docetaxel by tilting the ceramide/S1P balance toward cell death.	Ceramides	107-115	sphingosine-1-phosphate lyase 1	Homo sapiens	36-39